Accéder directement au contenu Accéder directement à la navigation
Article dans une revue

S. mansoni Bolsters Anti-Viral Immunity in the Murine Respiratory Tract

Abstract : The human intestinal parasite Schistosoma mansoni causes a chronic disease, schistosomiasis or bilharzia. According to the current literature, the parasite induces vigorous immune responses that are controlled by Th2 helper cells at the expense of Th1 helper cells. The latter cell type is, however, indispensable for anti-viral immune responses. Remarkably, there is no reliable literature among 230 million patients worldwide describing defective anti-viral immune responses in the upper respiratory tract, for instance against influenza A virus or against respiratory syncitial virus (RSV). We therefore re-examined the immune response to a human isolate of S. mansoni and challenged mice in the chronic phase of schistosomiasis with influenza A virus, or with pneumonia virus of mice (PVM), a mouse virus to model RSV infections. We found that mice with chronic schistosomiasis had significant, systemic immune responses induced by Th1, Th2, and Th17 helper cells. High serum levels of TNF-α, IFN-γ, IL-5, IL-13, IL-2, IL-17, and GM-CSF were found after mating and oviposition. The lungs of diseased mice showed low-grade inflammation, with goblet cell hyperplasia and excessive mucus secretion, which was alleviated by treatment with an anti-TNF-α agent (Etanercept). Mice with chronic schistosomiasis were to a relative, but significant extent protected from a secondary viral respiratory challenge. The protection correlated with the onset of oviposition and TNF-α-mediated goblet cell hyperplasia and mucus secretion, suggesting that these mechanisms are involved in enhanced immune protection to respiratory viruses during chronic murine schistosomiasis. Indeed, also in a model of allergic airway inflammation mice were protected from a viral respiratory challenge with PVM
Type de document :
Article dans une revue
Liste complète des métadonnées

Littérature citée [87 références]  Voir  Masquer  Télécharger
Contributeur : Anne Modat Connectez-vous pour contacter le contributeur
Soumis le : mardi 3 février 2015 - 15:08:37
Dernière modification le : mercredi 5 mai 2021 - 13:48:08
Archivage à long terme le : : mercredi 27 mai 2015 - 16:22:19


Fichiers éditeurs autorisés sur une archive ouverte



Sebastian Scheer, Christine Krempl, Carsten Kallfass, Stefanie Frey, Thilo Jakob, et al.. S. mansoni Bolsters Anti-Viral Immunity in the Murine Respiratory Tract. PLoS ONE, Public Library of Science, 2014, 9 (11), pp.e112469. ⟨10.1371/journal.pone.0112469⟩. ⟨hal-01112716⟩



Les métriques sont temporairement indisponibles