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Oxidation of Sperm Nucleus in Mammals: A Physiological Necessity to Some Extent with Adverse Impacts on Oocyte and Offspring

Abstract : Sperm cells have long been known to be good producers of reactive oxygen species, while they are also known to be particularly sensitive to oxidative damage affecting their structures and functions. As with all organic cellular components, sperm nuclear components and, in particular, nucleic acids undergo oxidative alterations that have recently been shown to be commonly encountered in clinical practice. This review will attempt to provide an overview of this situation. After a brief coverage of the biological reasons why the sperm nucleus and associated DNA are sensitive to oxidative damage, a summary of the most recent results concerning the oxidation of sperm DNA in animal and human models will be presented. The study will then attempt to cover the possible consequences of sperm nuclear oxidation on male fertility and beyond.
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https://hal.archives-ouvertes.fr/hal-03670194
Contributor : Joel Drevet Connect in order to contact the contributor
Submitted on : Tuesday, May 17, 2022 - 11:52:51 AM
Last modification on : Monday, May 23, 2022 - 11:36:37 AM

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Joël J. Drevet, Robert Aitken. Oxidation of Sperm Nucleus in Mammals: A Physiological Necessity to Some Extent with Adverse Impacts on Oocyte and Offspring. Antioxidants , MDPI, 2020, 9 (2), pp.95. ⟨10.3390/antiox9020095⟩. ⟨hal-03670194⟩

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