Skip to Main content Skip to Navigation
Journal articles

Cross-reactivity between tumor MHC class I-restricted antigens and an enterococcal bacteriophage

Aurélie Fluckiger 1, 2 Romain Daillere 1, 2 Mohamed Sassi 3 Barbara Sixt 4, 1, 5 Peng Liu 1, 5 Friedemann Loos 1, 5 Corentin Richard 6, 7 Catherine Rabu 8 Maryam Tidjani 1, 2, 9 Anne-Gaëlle Goubet 1, 2 Fabien Lemaitre 1 Gladys Ferrere 1, 2 Lisa Derosa 1, 2, 10 Connie Duong 1, 2 Meriem Messaoudene 11 Andréanne Gagné 11 Philippe Joubert 11 Luisa de Sordi 12, 13 Laurent Debarbieux 12 Sylvain Simon 8 Clara-Maria Scarlata 14 Maha Ayyoub 14 Belinda Palermo 15 Francesco Facciolo 15 Romain Boidot 16 Richard Wheeler 12 Ivo Gomperts Boneca 12 Zsofia Sztupinszki 17 Krisztian Papp 18 Istvan Csabai 18 Edoardo Pasolli 19 Nicola Segata 19 Carlos López-Otín 5, 20 Zoltan Szallasi 17 Fabrice Andre 1 Valerio Iebba 1 Valentin Quiniou 21 David Klatzmann 21 Jacques Boukhalil 9 Saber Khelaifia 9 Didier Raoult 9 Laurence Albiges 1 Bernard Escudier 1 Alexander Eggermont 1 Fathia Mami-Chouaib 22 Paola Nistico 15 François Ghiringhelli 16 Bertrand Routy 23 Nathalie Labarrière 8 Vincent Cattoir 24 Guido Kroemer 1, 25 Laurence Zitvogel 1, 2, 10, 25
Abstract : Intestinal microbiota have been proposed to induce commensal-specific memory T cells that cross-react with tumor-associated antigens. We identified major histocompatibility complex (MHC) class I-binding epitopes in the tail length tape measure protein (TMP) of a prophage found in the genome of the bacteriophage Enterococcus hirae Mice bearing E. hirae harboring this prophage mounted a TMP-specific H-2Kb-restricted CD8+ T lymphocyte response upon immunotherapy with cyclophosphamide or anti-PD-1 antibodies. Administration of bacterial strains engineered to express the TMP epitope improved immunotherapy in mice. In renal and lung cancer patients, the presence of the enterococcal prophage in stools and expression of a TMP-cross-reactive antigen by tumors correlated with long-term benefit of PD-1 blockade therapy. In melanoma patients, T cell clones recognizing naturally processed cancer antigens that are cross-reactive with microbial peptides were detected.
Document type :
Journal articles
Complete list of metadatas

Cited literature [56 references]  Display  Hide  Download

https://www.hal.inserm.fr/inserm-02923397
Contributor : Elizabeth Bernardo <>
Submitted on : Thursday, August 27, 2020 - 9:41:46 AM
Last modification on : Wednesday, October 14, 2020 - 4:21:03 AM

File

 Restricted access
To satisfy the distribution rights of the publisher, the document is embargoed until : 2021-02-21

Please log in to resquest access to the document

Identifiers

Citation

Aurélie Fluckiger, Romain Daillere, Mohamed Sassi, Barbara Sixt, Peng Liu, et al.. Cross-reactivity between tumor MHC class I-restricted antigens and an enterococcal bacteriophage. Science, American Association for the Advancement of Science, 2020, 369 (6506), pp.936-942. ⟨10.1126/science.aax0701⟩. ⟨inserm-02923397⟩

Share

Metrics

Record views

106