A microstrip resonator based sensor for GHz characterization of in vitro cell culture

Florian Kölbl (1) , N Boulboul (1) , M Commereuc (1) , E Bourdel (1)

1 ETIS - UMR 8051 - Equipes Traitement de l'Information et Systèmes

This contribution describes a sensor for GHz characterization of in vitro cell culture, that overcomes the limitation in high frequency of classical bio-impedance spectroscopy. The sensor we developed enables to monitor a thin layer of approximatively 30µm of cells in their liquid culture medium for a relative permittivity in the range of 5 to 55. Here, we demonstrate the measurement principle using a Finite Element model, which has been validated with experimental response. Our sensor has a minimal sensitivity of 0.3M Hz. We also used a multiphysics model to demonstrate that this technology does not affect tissue safety for input power level compatible with a sufficient measurement signal on noise ratio. This technology will be used in experiments aiming at the exploration of biomarkers for post-implantation inflammatory reactions of active devices.

Domaines: Electronique

Florian Kölbl, N Boulboul, M Commereuc, E Bourdel. A microstrip resonator based sensor for GHz characterization of in vitro cell culture. 12th International Conference On Sensing Technology (ICST 2018), Dec 2018, Limerick, Ireland. ⟨hal-01985834⟩