Accéder directement au contenu Accéder directement à la navigation
Article dans une revue

A new role under sortilin's belt in cancer

Abstract : The neurotensin receptor-3 also known as sortilin was the first member of the small family of vacuolar protein sorting 10 protein domain (Vps10p) discovered two decades ago in the human brain. The expression of sortilin is not confined to the nervous system but sortilin is ubiquitously expressed in many tissues. Sortilin has multiple roles in the cell as a receptor or a co-receptor, in protein transport of many interacting partners to the plasma membrane, to the endocytic pathway and to the lysosomes for protein degradation. Sortilin could be considered as the cells own shuttle system. In many human diseases including neurological diseases and cancer, sortilin expression has been shown to be deregulated. In addition, some studies have highlighted that the extracellular domain of sortilin is shedded into the culture media by an unknown mechanism. Sortilin can be released in exosomes and appears to control some mechanisms of exosome biogenesis. In lung cancer cells, sortilin can associate with two receptor tyrosine kinase receptors called the TES complex found in exosomes. Exosomes carrying the TES complex can convey a microenvironment control through the activation of ErbB signaling pathways and the release of angiogenic factors. Deregulation of sortilin function is now emerging to be implicated in four major human diseases - cardiovascular disease, Type 2 diabetes mellitus, Alzheimer disease and cancer.
Type de document :
Article dans une revue
Liste complète des métadonnées

https://hal-unilim.archives-ouvertes.fr/hal-01337629
Contributeur : Cornelia Wilson Connectez-vous pour contacter le contributeur
Soumis le : vendredi 15 octobre 2021 - 10:01:43
Dernière modification le : mercredi 3 novembre 2021 - 08:22:41

Fichier

Wilson et al 2016 adden.pdf
Fichiers éditeurs autorisés sur une archive ouverte

Identifiants

Collections

Citation

Cornelia M Wilson, Thomas Naves, Al-Akhrass Hussein, François Vincent, Boris Melloni, et al.. A new role under sortilin's belt in cancer. Communicative and Integrative Biology, Taylor & Francis Open, 2016, 9 (1), pp.e1130192. ⟨10.1080/19420889.2015.1130192⟩. ⟨hal-01337629⟩

Partager

Métriques

Consultations de la notice

24

Téléchargements de fichiers

30