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Membrane Crossing and Membranotropic Activity of Cell-Penetrating Peptides: Dangerous Liaisons ?

Abstract : Living organisms have to maintain a stable balance in molecules and ions in the changing environment in which they are living, a process known as homeostasis. At the level of cells, the plasma membrane has a major role in homeostasis, since this hydrophobic film prevents passive diffusion of large and hydrophilic molecules between the extracellular and intracellular milieu. Living organisms have evolved with highly sophisticated transport systems to control exchanges across this barrier: import of nutrients and fuel essential for their survival; recognition of chemical or physical messengers allowing information interchanges with surrounding cells. Besides specialized proteins, endocytosis mechanisms at the level of the lipid bilayer can transport molecules from the outside across the cell membrane, in an energy-dependent manner.
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Astrid Walrant, Sébastien Cardon, Fabienne Burlina, Sandrine Sagan. Membrane Crossing and Membranotropic Activity of Cell-Penetrating Peptides: Dangerous Liaisons ?. Accounts of Chemical Research, American Chemical Society, In press, ⟨10.1021/acs.accounts.7b00455⟩. ⟨hal-01662041⟩

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