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ASES: visualizing evolutionary conservation of alternative splicing in proteins

Abstract : ASES is a versatile tool for assessing the impact of alternative splicing (AS), initiation and termination of transcription on protein diversity in evolution. It identifies exon and transcript orthogroups from a set of input genes/species for comparative transcriptomics analyses. It computes an evolutionary splicing graph, where the nodes are exon orthogroups, allowing for a direct evaluation of AS conservation. It also reconstructs a transcripts’ phylogenetic forest to date the appearance of specific transcripts and explore the events that have shaped them. ASES web server features a highly interactive interface enabling the synchronous selection of events, exons or transcripts in the different outputs, and the visualization and retrieval of the corresponding amino acid sequences, for subsequent 3D structure prediction.
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https://hal.sorbonne-universite.fr/hal-03695534
Contributor : Elodie Laine Connect in order to contact the contributor
Submitted on : Tuesday, June 14, 2022 - 10:20:43 PM
Last modification on : Saturday, June 25, 2022 - 3:29:13 AM

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Diego Javier Zea, Hugues Richard, Elodie Laine. ASES: visualizing evolutionary conservation of alternative splicing in proteins. Bioinformatics, Oxford University Press (OUP), 2022, 38 (9), pp.2615-2616. ⟨10.1093/bioinformatics/btac105⟩. ⟨hal-03695534⟩

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