Genetic characterization of wild-type measles viruses in Cambodia

Srey Viseth Horm (1) , Céline Dumas (1) , Sarath Svay (2) , Keith Feldon (3) , Jean-Marc Reynes (1)

1 Institut Pasteur du Cambodge
2 Ministry of Health [Phnom Penh]
3 WHO - World Health Organization [Phnom Penh]

Cambodian authorities in collaboration with the World Health Organization (WHO) are implementing a measles control plan in this measles endemic country. Genetic characterization of Cambodian wild-type measles viruses was performed to determine the genotypes involved in outbreaks, and to measure the level of virus circulation in a geographic area just beginning to implement the measles control program. Seventy-two sequences of the C terminus of the nucleoprotein gene of measles virus were obtained from 88 patients. Samples were taken from 35 among 519 outbreaks reported to the Cambodian National Immunization Program between March 2001 and June 2002. The sequences were grouped into 10 lineages which all belonged to genotype D5. The maximum nucleotide divergence was 1.3%.

Mots clés: Measles; Cambodia; Genotype

Domaines: Maladies infectieuses; Virologie; Santé publique et épidémiologie

Srey Viseth Horm, Céline Dumas, Sarath Svay, Keith Feldon, Jean-Marc Reynes. Genetic characterization of wild-type measles viruses in Cambodia. Virus Research, 2003, 97 (1), pp.31 - 37. ⟨10.1016/S0168-1702(03)00219-3⟩. ⟨pasteur-01836719⟩