Class D OXA-48 Carbapenemase in Multidrug-Resistant Enterobacteria, Senegal

Olivier Moquet (1) , Coralie Bouchiat (1) , Alfred Dieudonné Kinana (1) , Abdoulaye Seck (1) , Omar Arouna (2) , Raymond Bercion (2) , Sebastien Breurec (1) , Benoit Garin (1)

1 Institut Pasteur de Dakar
2 Hopital Principal de Dakar

Class D OXA β-lactamases are characterized as penicillinases that can hydrolyze oxacillin and cloxacillin and are poorly inhibited by clavulanic acid and EDTA. OXA-48 is one of the few members of this family to possess notable carbapenem-hydrolyzing activity. First described in 2004 in Turkey, OXA-48 has recently started to spread in Europe and the Middle East. We report the recent emergence of the plasmid-encoded bla OXA-48 gene in multidrug-resistant Enterobacteriaceae recovered from patients in Dakar, Senegal, in hospitals and in the community.

Domaines: Bactériologie; Maladies infectieuses

Olivier Moquet, Coralie Bouchiat, Alfred Dieudonné Kinana, Abdoulaye Seck, Omar Arouna, et al.. Class D OXA-48 Carbapenemase in Multidrug-Resistant Enterobacteria, Senegal. Emerging Infectious Diseases, 2011, 17 (1), pp.143-144. ⟨10.3201/eid1701.100224⟩. ⟨hal-01348289⟩