Genetic Characterization of Enterovirus A71 Circulating in Africa

Maria Dolores Fernandez-Garcia (1) , Romain Volle (2, 3) , Marie-Line Joffret (2, 3) , Serge Alain Sadeuh-Mba (4) , Ionela Gouandjika-Vasilache (5) , Ousmane Kebe (1) , Michael R Wiley (6, 7) , Manasi Majumdar (8) , Etienne Simon-Loriere (2) , Anavaj Sakuntabhai (2) , Gustavo Palacios (7) , Javier Martin (8) , Francis Delpeyroux (2, 3) , Kader Ndiaye (1) , Maël N Bessaud (2)

1 Institut Pasteur de Dakar
2 IP - Institut Pasteur [Paris]
3 INSERM - Institut National de la Santé et de la Recherche Médicale
4 Centre Pasteur du Cameroun
5 Institut Pasteur de Bangui
6 University of Nebraska Medical Center
7 USAMRIID - U.S. Army Medical Research Institute of Infectious Diseases
8 NIBSC - National Institute for Biological Standards and Control

We analyzed whole-genome sequences of 8 enterovirus A71 isolates (EV-A71). We confirm the circulation of geno-group C and the new genogroup E in West Africa. Our analysis demonstrates wide geographic circulation and describes genetic exchanges between EV-A71 and autochtho-nous EV-A that might contribute to the emergence of patho-genic lineages.

Mots clés: Africa; acute flaccid paralysis; enterovirus; enterovirus A71; phylogenetic analysis; recombination; viruses; whole-genome analysis

Domaines: Santé publique et épidémiologie; Maladies infectieuses; Génétique

Maria Dolores Fernandez-Garcia, Romain Volle, Marie-Line Joffret, Serge Alain Sadeuh-Mba, Ionela Gouandjika-Vasilache, et al.. Genetic Characterization of Enterovirus A71 Circulating in Africa. Emerging Infectious Diseases, 2018, 24 (4), pp.754 - 757. ⟨10.3201/eid2404.171783⟩. ⟨pasteur-01745950⟩