Acute Kidney Injury Induces Remote Cardiac Damage and Dysfunction Through the Galectin-3 Pathway

Mathilde Prud'Homme (1) , Maxime Coutrot (1, 2) , Thibault Michel (1) , Louis Boutin (1, 2) , Magali Genest (1, 3) , Françoise Poirier (4) , Jean-Marie Launay (1) , Bocar Kane (5) , Satoshi Kinugasa (3) , Niki Prakoura (3) , Sophie Vandermeersch (3) , Alain Cohen-Solal (1, 6) , Claude Delcayre (1) , Jane-Lise Samuel (1) , Ravindra Mehta (7) , Etienne Gayat (1, 2) , Alexandre Mebazaa (1, 6) , Christos Chadjichristos (8) , Matthieu Legrand (1, 9, 2)

1 MASCOT (UMR_S_942 / U942) - Marqueurs cardiovasculaires en situation de stress
2 AP-HP - Hopital Saint-Louis [AP-HP]
3 Des Maladies Rénales Rares aux Maladies Fréquentes, Remodelage et Réparation
4 IJM (UMR_7592) - Institut Jacques Monod
5 UMS28 - Phénotypage du petit animal
6 Hôpital Lariboisière-Fernand-Widal [APHP]
7 UC San Diego - University of California [San Diego]
8 Matrice extracellulaire normale et pathologique
9 UC San Francisco - University of California [San Francisco]

Acute kidney injury is associated with increased risk of heart failure and mortality. This study demonstrates that acute kidney injury induces remote cardiac dysfunction, damage, injury, and fibrosis via a galectin-3 (Gal-3) dependent pathway. Gal-3 originates from bone marrow-derived immune cells. Cardiac damage could be prevented by blocking this pathway.

Mots clés: fibrosis; heart failure; inflammation; macrophages; renal failure

Domaines: Sciences du Vivant [q-bio]

Mathilde Prud'Homme, Maxime Coutrot, Thibault Michel, Louis Boutin, Magali Genest, et al.. Acute Kidney Injury Induces Remote Cardiac Damage and Dysfunction Through the Galectin-3 Pathway. JACC : Basic to Translational Science, 2019, 4 (6), pp.717 - 732. ⟨10.1016/j.jacbts.2019.06.005⟩. ⟨hal-03489287⟩