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Une étude translationnelle de la néphropathie à IgA de l’enfant : des variants génétiques à la physiopathologie des biomarqueurs et leurs liens de causalité avec les lésions histologiques

Abstract : IgAN is an autoimmune disease and its pathogenesis involves galactose deficient (Gd) IgA1, IgG anti-Gd-IgA1 autoantibodies and the soluble IgA Fc receptor (sCD89).Free and IgA1-complexed sCD89 are key players in mesangial proimeration through CD71 receptor. These findings reveal a new role for sCD89 in clgAN, making t a potentially useful biomarker and therapeutic target.sCD89-IgA1 complexes and free sCD89 correlate with proteinunia, es well as histological markers of disease activity: mesangial, endocapillary and extracapillary proliferation. These biomarkors could represent a useful approach to evaluate kidney injury without the need of repeated kidney biopsies Previous works have suggested that familial IgAN could be linked tochromosome s 2g36 region, which is also the coding region for COL4A3/A4.COL4A3 heterozygous variants seems to get a predisposition io senous IgAN presentation. COL4A3 variant at early stage of clgAN could represent a helptul tool to stratty the severity of cigAN beyond the Oxford classification.
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https://tel.archives-ouvertes.fr/tel-03407272
Contributor : Abes Star :  Contact
Submitted on : Thursday, October 28, 2021 - 1:13:16 PM
Last modification on : Friday, December 3, 2021 - 11:43:18 AM
Long-term archiving on: : Saturday, January 29, 2022 - 7:22:55 PM

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CAMBIER_Alexandra_2020.pdf
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  • HAL Id : tel-03407272, version 1

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Alexandra Cambier. Une étude translationnelle de la néphropathie à IgA de l’enfant : des variants génétiques à la physiopathologie des biomarqueurs et leurs liens de causalité avec les lésions histologiques. Urologie et Néphrologie. Sorbonne Université, 2020. Français. ⟨NNT : 2020SORUS371⟩. ⟨tel-03407272⟩

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