Delivery systems of local anesthetics in bone surgery: are they efficient and safe?

Manon Dupleichs (1, 2) , Qiman Gao (3) , Zahi Badran (1, 3) , Pascal Janvier (2) , Jean-Michel Bouler (2) , Olivier Gauthier (1, 4) , Faleh Tamimi (3) , Elise Verron (2, 5)

1 RMeS - Regenerative Medicine and Skeleton
2 CEISAM - Chimie Et Interdisciplinarité : Synthèse, Analyse, Modélisation
3 Faculty of Dentistry [Montreal, Canada]
4 ONIRIS - École nationale vétérinaire, agroalimentaire et de l'alimentation Nantes-Atlantique
5 Université de Nantes - UFR des Sciences Pharmaceutiques et Biologiques

Management of postoperative pain following bone surgery includes administration of local anesthetics (LAs). Smart delivery systems, including triggered systems, have been designed to provide a continuous release of LA in situ. However, these systems can provide a high level of LA locally. This review will examine the state-of-the-art regarding the LA delivery systems optimized for management of postoperative pain in bone surgery and will discuss the potential adverse effects of LAs on the overall pathways of bone healing, including the inflammation response phase, hemostasis phase, tissue repair phase and remodeling phase. There is a clinical need to document these effects and the potential impacts on the clinical outcome of the patient.

Domaines: Rhumatologie et système ostéo-articulaire; Gériatrie et gérontologie

Manon Dupleichs, Qiman Gao, Zahi Badran, Pascal Janvier, Jean-Michel Bouler, et al.. Delivery systems of local anesthetics in bone surgery: are they efficient and safe?. Drug Discovery Today, 2018, Epub ahead of print. ⟨10.1016/j.drudis.2018.06.019⟩. ⟨inserm-01843939⟩