One of the immune activation profiles observed in HIV-1-infected adults with suppressed viremia is linked to metabolic syndrome: The ACTIVIH study

C Psomas (1, 2) , M Younas (1) , Christelle Reynes (3) , R Cezar (4) , P Portalès (5) , E Tuaillon (6) , A Guigues (1) , C Merle (2) , N Atoui (2) , C Fernandez (2, 7) , V Le Moing (2, 7) , C Barbuat (4) , G Marin (5) , N Nagot (6, 5) , A Sotto (4, 8) , J.-F. Eliaou (5, 9) , Robert Sabatier (3) , J Reynes (2, 7) , P Corbeau (1, 4)

1 IGH - Institut de génétique humaine
2 Département Maladies Infectieuses et Tropicales, Hôpital Universitaire, Montpellier, France
3 IGF - Institut de Génomique Fonctionnelle
4 CHU Nîmes - Centre Hospitalier Universitaire de Nîmes
5 CHRU Montpellier - Centre Hospitalier Régional Universitaire [Montpellier]
6 Pathogénèse et contrôle des infections chroniques (PCCI)
7 TransVIHMI - Recherches Translationnelles sur le VIH et les maladies infectieuses endémiques et émergentes
8 VBMI - Virulence bactérienne et maladies infectieuses
9 IRCM - U1194 Inserm - UM - Institut de Recherche en Cancérologie de Montpellier

Immune activation in HIV-1-infected individuals is reduced under antiretroviral therapies, but persists, resulting in various morbidities. To better characterize this phenomenon, using a panel of 68 soluble and cell surface markers, we measured the level of activation in circulating CD4+ and CD8+ T cells, B cells, monocytes, NK cells, polynuclear and endothelial cells as well as of inflammation and fibrinolysis in 120 virologic responders over 45 years of age. As compared with age-and sex-matched uninfected individuals, we observed a persistence of activation in all the cell subpopulations analyzed, together with marks of inflammation and fibrinolysis. Two independent hierarchical clustering analyses allowed us to identify five clusters of markers that varied concurrently , and five patient groups, each with the same activation profile. The five groups of patients could be characterized by a marker of CD4+ T cell, CD8+ T cell, NK cell, monocyte activation or of inflammation, respectively. One of these profiles was strongly associated with marks of metabolic syndrome, particularly with hyperinsulinemia (OR 12.17 [95% CI 1.79-82.86], p = 0.011). In conclusion, our study unveils biomarkers linked to metabolic syndrome that could be tested as predictive markers, and opens the way to new therapeutic approaches tailored to each patient group.

Mots clés: Hyperinsulinemia; Cell activation; Inflammation; Coagulation; Endothelium

Domaines: Maladies infectieuses; Immunité innée; Immunité adaptative

C Psomas, M Younas, Christelle Reynes, R Cezar, P Portalès, et al.. One of the immune activation profiles observed in HIV-1-infected adults with suppressed viremia is linked to metabolic syndrome: The ACTIVIH study. EBioMedicine, 2016, 8, pp.265-276. ⟨10.1016/j.ebiom.2016.05.008⟩. ⟨hal-01351341⟩