Cytoplasmic and Nuclear Forms of Thyroid Hormone Receptor β1 Are Inversely Associated with Survival in Primary Breast Cancer

Wanting Shao (1) , Christina Kuhn (1) , Doris Mayr (1) , Nina Ditsch (1) , Magdalena Kailuweit (1) , Verena Wolf (1) , Nadia Harbeck (1) , Sven Mahner (1) , Udo Jeschke (1) , Vincent Cavaillès (2) , Sophie Sixou (1, 3)

1 LMU - Ludwig Maximilian University [Munich] = Ludwig Maximilians Universität München
2 IRCM - U1194 Inserm - UM - Institut de Recherche en Cancérologie de Montpellier
3 IUCT Oncopole - UMR 1037 - Institut Universitaire du Cancer de Toulouse - Oncopole

The aim of this study was to investigate the expression of thyroid hormone receptor β1 (THRβ1) by immunohistochemistry in breast cancer (BC) tissues and to correlate the results with clinico-biological parameters. In a well-characterized cohort of 274 primary BC patients, THRβ1 was widely expressed with a predominant nuclear location, although cytoplasmic staining was also frequently observed. Both nuclear and cytoplasmic THRβ1 were correlated with high-risk BC markers such as human epidermal growth factor receptor 2 (HER2), Ki67 (also known as MKI67), prominin-1 (CD133), and N-cadherin. Overall survival analysis demonstrated that cytoplasmic THRβ1 was correlated with favourable survival (p = 0.015), whereas nuclear THRβ1 had a statistically significant correlation with poor outcome (p = 0.038). Interestingly, in our cohort, nuclear and cytoplasmic THRβ1 appeared to be independent markers either for poor (p = 0.0004) or for good (p = 0.048) prognosis, respectively. Altogether, these data indicate that the subcellular expression of THRβ1 may play an important role in oncogenesis. Moreover, the expression of nuclear THRβ1 is a negative outcome marker, which may help to identify high-risk BC subgroups.

Mots clés: thyroid hormone receptor beta 1; subcellular localization; overall survival; breast cancer

Domaines: Sciences du Vivant [q-bio]

Wanting Shao, Christina Kuhn, Doris Mayr, Nina Ditsch, Magdalena Kailuweit, et al.. Cytoplasmic and Nuclear Forms of Thyroid Hormone Receptor β1 Are Inversely Associated with Survival in Primary Breast Cancer. International Journal of Molecular Sciences, 2020, 21 (1), pp.330. ⟨10.3390/ijms21010330⟩. ⟨hal-02996305⟩