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The Xanthate Route to Amino Acids

Abstract : The degenerative xanthate addition transfer to alkenes allows the synthesis of a broad range of protected, and in some cases enantiopure, α, β, and γ-amino acids, including proline and pipecolic derivatives, as well as fluorinated congeners and β-lactams. The radical addition furnishes naturally latent mercapto-α-amino acids that are ideally equipped for native chemical ligation. Most of the amino acid structures accessible rapidly by this chemistry would otherwise require tedious multi-step syntheses.
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Contributor : Samir Zard Connect in order to contact the contributor
Submitted on : Friday, November 5, 2021 - 1:33:51 PM
Last modification on : Tuesday, January 4, 2022 - 5:55:38 AM


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Samir Zard. The Xanthate Route to Amino Acids. CHIMIA, Schweizerische Chemische Gesellschaft, 2020, 74 (1), pp.9-17. ⟨10.2533/chimia.2020.9⟩. ⟨hal-03416886⟩



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