Skip to Main content Skip to Navigation
Journal articles

A Convergent Route to b-Amino Acids and to b-Heteroarylethylamines. An Unexpected Vinylation Reaction

Abstract : Various protected β2-amino acids can be prepared by radical addition of β-phthalimido-α-xanthyl propionic acid, both as the free acid or as the ethyl ester. Successive radical additions provide access to more complex structures. In the case of the free acid, addition to certain heteroaromatics leads directly to β-heteroarylethylamines through spontaneous decarboxylation of the intermediate adduct. Forcing the decarboxylation in some cases generated a vinyl group by decarboxylative elimination of the phthalimido group.
Document type :
Journal articles
Complete list of metadata

https://hal.archives-ouvertes.fr/hal-03416909
Contributor : Samir Zard Connect in order to contact the contributor
Submitted on : Friday, November 5, 2021 - 1:48:19 PM
Last modification on : Tuesday, January 4, 2022 - 5:55:38 AM

File

Beta-Amino Acids-Ms-OL-Revised...
Files produced by the author(s)

Identifiers

Collections

Citation

Xuan Chen, Samir Zard. A Convergent Route to b-Amino Acids and to b-Heteroarylethylamines. An Unexpected Vinylation Reaction. Organic Letters, American Chemical Society, 2020, 22 (9), pp.3628-3632. ⟨10.1021/acs.orglett.0c01087⟩. ⟨hal-03416909⟩

Share

Metrics

Les métriques sont temporairement indisponibles