N. Kim, M. Piatyszek, and K. Prowse, Specific association of human telomerase activity with immortal cells and cancer, Science, vol.266, issue.5193, pp.2011-2016, 1994.
DOI : 10.1126/science.7605428

J. Henson and R. Reddel, Assaying and investigating Alternative Lengthening of Telomeres activity in human cells and cancers, FEBS Letters, vol.108, issue.17, pp.3800-3811, 2010.
DOI : 10.1016/j.febslet.2010.06.009

A. Cesare and R. Reddel, Alternative lengthening of telomeres: models, mechanisms and implications, Nature Reviews Genetics, vol.106, issue.5, pp.319-349, 2010.
DOI : 10.1038/nrg2763

C. Scheel, K. Schaefer, and A. Jauch, Alternative lengthening of telomeres is associated with chromosomal instability in osteosarcomas, Oncogene, vol.20, issue.29, pp.3835-3879, 2001.
DOI : 10.1038/sj.onc.1204493

J. Henson, J. Hannay, and . Mccarthy, A robust assay for alternative lengthening of telomeres in tumors shows the significance of alternative lengthening of telomeres in sarcomas and astrocytomas, Clin Cancer Res, vol.11, pp.217-242, 2005.

D. Silvestre, J. Pineda, and F. Hoffschir, Alternative Lengthening of Telomeres in Human Glioma Stem Cells, STEM CELLS, vol.64, issue.3, pp.440-51, 2011.
DOI : 10.1002/stem.600

C. Heaphy, K. Schreck, and E. Raabe, A glioblastoma neurosphere line with alternative lengthening of telomeres, Acta Neuropathologica, vol.3, issue.4, pp.607-615, 2013.
DOI : 10.1007/s00401-013-1174-x

S. Bao, Q. Wu, and R. Mclendon, Glioma stem cells promote radioresistance by preferential activation of the DNA damage response, Nature, vol.8, issue.7120, pp.756-60, 2006.
DOI : 10.1038/nature05236

M. Ruden and N. Puri, Novel anticancer therapeutics targeting telomerase, Cancer Treatment Reviews, vol.39, issue.5, pp.444-56, 2013.
DOI : 10.1016/j.ctrv.2012.06.007

URL : http://indigo.uic.edu/bitstream/handle/10027/10976/Publ_hTERTinhibs_w.refworks_w.tbls.Rev10_MR.pdf?sequence=2

J. Hu, S. Hwang, and M. Liesa, Antitelomerase Therapy Provokes ALT and Mitochondrial Adaptive Mechanisms in Cancer, Cell, vol.148, issue.4, pp.651-63, 2012.
DOI : 10.1016/j.cell.2011.12.028

C. Schaffitzel, I. Berger, and J. Postberg, In vitro generated antibodies specific for telomeric guanine-quadruplex DNA react with Stylonychia lemnae macronuclei, Proceedings of the National Academy of Sciences, vol.98, issue.15, pp.8572-8579, 2001.
DOI : 10.1073/pnas.141229498

S. Gowan, J. Harrison, and L. Patterson, A G-Quadruplex-Interactive Potent Small-Molecule Inhibitor of Telomerase Exhibiting in Vitro and in Vivo Antitumor Activity, Molecular Pharmacology, vol.61, issue.5, pp.1154-62, 2002.
DOI : 10.1124/mol.61.5.1154

A. Burger, F. Dai, and C. Schultes, The G-Quadruplex-Interactive Molecule BRACO-19 Inhibits Tumor Growth, Consistent with Telomere Targeting and Interference with Telomerase Function, Cancer Research, vol.65, issue.4, pp.1489-96, 2005.
DOI : 10.1158/0008-5472.CAN-04-2910

T. Tauchi, K. Shin-ya, and G. Sashida, Activity of a novel G-quadruplex-interactive telomerase inhibitor, telomestatin (SOT-095), against human leukemia cells: involvement of ATM-dependent DNA damage response pathways, Oncogene, vol.22, issue.34, pp.5338-5385, 2003.
DOI : 10.1038/sj.onc.1206833

J. Riou, L. Guittat, and P. Mailliet, Cell senescence and telomere shortening induced by a new series of specific G-quadruplex DNA ligands, Proceedings of the National Academy of Sciences, vol.99, issue.5, pp.2672-2679, 2002.
DOI : 10.1073/pnas.052698099

P. Phatak, J. Cookson, and F. Dai, Telomere uncapping by the G-quadruplex ligand RHPS4 inhibits clonogenic tumour cell growth in vitro and in vivo consistent with a cancer stem cell targeting mechanism, British Journal of Cancer, vol.77, issue.8, pp.1223-1256, 2007.
DOI : 10.1038/350718a0

G. Pennarun, C. Granotier, and L. Gauthier, Apoptosis related to telomere instability and cell cycle alterations in human glioma cells treated by new highly selective G-quadruplex ligands, Oncogene, vol.12, issue.18, pp.2917-2945, 2005.
DOI : 10.1038/sj.onc.1208468

L. Gauthier, C. Granotier, and F. Hoffschir, Rad51 and DNA-PKcs are involved in the generation of specific telomere aberrations induced by the quadruplex ligand 360A that impair mitotic cell progression and lead to cell death, Cellular and Molecular Life Sciences, vol.25, issue.13, pp.629-669, 2012.
DOI : 10.1007/s00018-011-0767-6

C. Granotier, G. Pennarun, and L. Riou, Preferential binding of a G-quadruplex ligand to human chromosome ends, Nucleic Acids Research, vol.33, issue.13, pp.4182-90, 2005.
DOI : 10.1093/nar/gki722

C. Patru, L. Romao, and P. Varlet, CD133, CD15/SSEA-1, CD34 or side populations do not resume tumor-initiating properties of long-term cultured cancer stem cells from human malignant glio-neuronal tumors, BMC Cancer, vol.4, issue.5, p.66, 2010.
DOI : 10.1016/j.stem.2009.03.003

URL : https://hal.archives-ouvertes.fr/inserm-00663773

G. Pennarun, C. Granotier, and F. Hoffschir, Role of ATM in the telomere response to the G-quadruplex ligand 360A, Nucleic Acids Research, vol.36, issue.5, pp.1741-54, 2008.
DOI : 10.1093/nar/gkn026

URL : https://hal.archives-ouvertes.fr/cea-00268952

E. Segal-bendirdjian and A. Jacquemin-sablon, Cisplatin Resistance in a Murine Leukemia Cell Line Is Associated with a Defective Apoptotic Process, Experimental Cell Research, vol.218, issue.1, pp.201-213, 1995.
DOI : 10.1006/excr.1995.1148

R. Zinn, K. Pruitt, and S. Eguchi, hTERT Is Expressed in Cancer Cell Lines Despite Promoter DNA Methylation by Preservation of Unmethylated DNA and Active Chromatin around the Transcription Start Site, Cancer Research, vol.67, issue.1, pp.194-201, 2007.
DOI : 10.1158/0008-5472.CAN-06-3396

J. Londono-vallejo, H. Der-sarkissian, and L. Cazes, Alternative Lengthening of Telomeres Is Characterized by High Rates of Telomeric Exchange, Cancer Research, vol.64, issue.7, pp.2324-2331, 2004.
DOI : 10.1158/0008-5472.CAN-03-4035

A. Cesare and J. Griffith, Telomeric DNA in ALT Cells Is Characterized by Free Telomeric Circles and Heterogeneous t-Loops, Molecular and Cellular Biology, vol.24, issue.22, pp.9948-57, 2004.
DOI : 10.1128/MCB.24.22.9948-9957.2004

J. Nosek, A. Rycovska, A. Makhov, and J. Griffith, Amplification of Telomeric Arrays via Rolling-circle Mechanism, Journal of Biological Chemistry, vol.280, issue.11, pp.10840-10845, 2005.
DOI : 10.1074/jbc.M409295200

A. Nabetani and F. Ishikawa, Unusual Telomeric DNAs in Human Telomerase-Negative Immortalized Cells, Molecular and Cellular Biology, vol.29, issue.3, pp.703-716, 2009.
DOI : 10.1128/MCB.00603-08

S. Kyo, M. Takakura, and T. Fujiwara, promoter regulation for diagnosis and treatment of human cancers, Cancer Science, vol.10, issue.8, pp.1528-1566, 2008.
DOI : 10.1111/j.1349-7006.2008.00878.x

K. Shin, M. Kang, and E. Dicterow, Hypermethylation of the hTERT promoter inhibits the expression of telomerase activity in normal oral fibroblasts and senescent normal oral keratinocytes, British Journal of Cancer, vol.89, issue.8, pp.1473-1481, 2003.
DOI : 10.1038/sj.bjc.6601291

N. Lopatina, J. Poole, and S. Saldanha, Control mechanisms in the regulation of telomerase reverse transcriptase expression in differentiating human teratocarcinoma cells, Biochemical and Biophysical Research Communications, vol.306, issue.3, pp.650-659, 2003.
DOI : 10.1016/S0006-291X(03)01033-7

W. Mueller, C. Nutt, and M. Ehrich, Downregulation of RUNX3 and TES by hypermethylation in glioblastoma, Oncogene, vol.32, issue.4, pp.583-93, 2007.
DOI : 10.1038/sj.onc.1209805

A. Azouz, Y. Wu, and J. Hillion, Epigenetic plasticity of hTERT gene promoter determines retinoid capacity to repress telomerase in maturation-resistant acute promyelocytic leukemia cells, Leukemia, vol.3, issue.3, pp.613-635, 2010.
DOI : 10.1016/S0006-291X(02)02775-4

S. Oh, Y. Song, and J. Yim, The Wilms' Tumor 1 Tumor Suppressor Gene Represses Transcription of the Human Telomerase Reverse Transcriptase Gene, Journal of Biological Chemistry, vol.274, issue.52, pp.37473-37481, 1999.
DOI : 10.1074/jbc.274.52.37473

E. Perez-navarro, E. Arenas, and J. Reiriz, Glial cell line-derived neurotrophic factor protects striatal calbindin-immunoreactive neurons from excitotoxic damage, Neuroscience, vol.75, issue.2, pp.345-52, 1996.
DOI : 10.1016/0306-4522(96)00336-3

J. Pineda, N. Rubio, and P. Akerud, Neuroprotection by GDNF-secreting stem cells in a Huntington's disease model: optical neuroimage tracking of brain-grafted cells, Gene Therapy, vol.24, pp.118-146, 2007.
DOI : 10.1038/sj.gt.3302847

S. Habu, H. Fukui, and K. Shimamura, In vivo effects of anti-asialo GM1. I. Reduction of NK activity and enhancement of transplanted tumor growth in nude mice, J Immunol, vol.127, pp.34-42, 1981.

V. Hakin-smith, D. Jellinek, and D. Levy, Alternative lengthening of telomeres and survival in patients with glioblastoma multiforme, The Lancet, vol.361, issue.9360, pp.836-844, 2003.
DOI : 10.1016/S0140-6736(03)12681-5

K. Mcdonald, J. Mcdonnell, and A. Muntoni, Presence of Alternative Lengthening of Telomeres Mechanism in Patients With Glioblastoma Identifies a Less Aggressive Tumor Type With Longer Survival, Journal of Neuropathology & Experimental Neurology, vol.69, issue.7, pp.729-765, 2010.
DOI : 10.1097/NEN.0b013e3181e576cf

O. Bechter, Y. Zou, and J. Shay, Homologous recombination in human telomerase-positive and ALT cells occurs with the same frequency, EMBO reports, vol.9, issue.12, pp.1138-1181, 2003.
DOI : 10.1038/sj.embor.7400027

A. Cesare, Z. Kaul, and S. Cohen, Spontaneous occurrence of telomeric DNA damage response in the absence of chromosome fusions, Nature Structural & Molecular Biology, vol.59, issue.12, pp.1244-51, 2009.
DOI : 10.1101/gad.1634008

A. Sfeir and T. De-lange, Removal of Shelterin Reveals the Telomere End-Protection Problem, Science, vol.336, issue.6081, pp.593-600, 2012.
DOI : 10.1126/science.1218498

S. Dessain, H. Yu, and R. Reddel, Methylation of the human telomerase gene CpG island, Cancer Res, vol.60, pp.537-578, 2000.

T. Devereux, I. Horikawa, and C. Anna, DNA methylation analysis of the promoter region of the human telomerase reverse transcriptase (hTERT) gene, Cancer Res, vol.59, pp.6087-90, 1999.

R. Stupp, W. Mason, and M. Van-den-bent, Radiotherapy plus Concomitant and Adjuvant Temozolomide for Glioblastoma, New England Journal of Medicine, vol.352, issue.10, pp.987-96, 2005.
DOI : 10.1056/NEJMoa043330