, Gene expression regulation in trypanosomatids. Essays. Biochem, vol.51, pp.31-46, 2011.
First WHO report on neglected tropical diseases: working to overcome the global impact of neglected tropical diseases.; Switzerland, 2010. ,
Trypanosoma cruzi: parasite and host cell signaling during the invasion process, Subcell. Biochem, vol.47, pp.82-91, 2008. ,
Interactive Multimedia to Teach the Life Cycle of Trypanosoma cruzi, the Causative Agent of Chagas Disease, PLoS Negl. Trop. Dis, vol.6, issue.8, p.1749, 2012. ,
Clinical and epidemiological aspects of Chagas disease, Lancet Infect. Dis, vol.1, issue.2, pp.92-100, 2001. ,
Predictors of visceral leishmaniasis relapse in HIV-infected patients: a systematic review, PLoS Negl. Trop. Dis, vol.5, issue.6, p.1153, 2011. ,
MEROPS: the database of proteolytic enzymes, their substrates and inhibitors, Nucleic Acids Res, vol.40, pp.343-350, 2012. ,
Effect of a novel prolyl endopeptidase inhibitor, JTP-4819, on thyrotropin-releasing hormone-like immunoreactivity in the cerebral cortex and hippocampus of aged rats, Jpn. J. Pharmacol, vol.69, issue.3, pp.273-276, 1995. ,
A comparison of the properties and enzymatic activities of three angiotensin processing enzymes: angiotensin converting enzyme, prolyl endopeptidase and neutral endopeptidase 24.11, Life Sci, issue.18, pp.1461-1480, 1993. ,
Therapeutic potential of dipeptidyl peptidase IV inhibitors for the treatment of type 2 diabetes, Expert Opin. Investig. Drugs, vol.12, issue.1, pp.87-100, 2003. ,
Improved glycaemic control with dipeptidyl peptidase-4 inhibition in patients with type 2 diabetes: vildagliptin (LAF237) dose response, Diabetes Obes. Metab, vol.7, issue.6, pp.692-698, 2005. ,
Effect of the dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy on glycemic control in patients with type 2 diabetes, Diabetes Care, vol.29, issue.12, pp.2632-2637, 2006. ,
Structural basis for gluten intolerance in celiac sprue, Science, vol.297, issue.5590, pp.2275-2279, 2002. ,
Protein engineering of improved prolyl endopeptidases for celiac sprue therapy, Protein Eng. Des. Sel, vol.21, issue.12, pp.699-707, 2008. ,
The Trypanosoma cruzi virulence factor oligopeptidase B (OPBTc) assembles into an active and stable dimer, PLoS One, vol.7, issue.1, p.30431, 2012. ,
URL : https://hal.archives-ouvertes.fr/hal-02319002
Crystal structure of Leishmania major oligopeptidase B gives insight into the enzymatic properties of a trypanosomatid virulence factor, J. Biol. Chem, issue.50, pp.39249-39259, 2010. ,
Prolyl oligopeptidase: an unusual beta-propeller domain regulates proteolysis, Cell, vol.94, issue.2, pp.161-170, 1998. ,
Catalysis of serine oligopeptidases is controlled by a gating filter mechanism, EMBO Rep, vol.1, issue.3, pp.277-281, 2000. ,
Flexibility of prolyl oligopeptidase: molecular dynamics and molecular framework analysis of the potential substrate pathways, Proteins, vol.60, issue.3, pp.504-512, 2005. ,
Concerted structural changes in the peptidase and the propeller domains of prolyl oligopeptidase are required for substrate binding, J. Mol. Biol, vol.340, issue.3, pp.627-637, 2004. ,
Structural and mechanistic analysis of two prolyl endopeptidases: role of interdomain dynamics in catalysis and specificity, Proc. Natl. Acad. Sci. U S A, vol.102, issue.10, pp.3599-3604, 2005. ,
Induced-fit mechanism for prolyl endopeptidase, J. Biol. Chem, issue.28, pp.21487-21495, 2010. ,
Molecular dynamics, crystallography and mutagenesis studies on the substrate gating mechanism of prolyl oligopeptidase, Biochimie, vol.94, issue.6, pp.1398-1411, 2012. ,
Structural analysis of prolyl oligopeptidases using molecular docking and dynamics: insights into conformational changes and ligand binding, PLoS One, vol.6, issue.11, p.26251, 2011. ,
Pyrrolidinyl pyridone and pyrazinone analogues as potent inhibitors of prolyl oligopeptidase (POP), Bioorg. Med. Chem. Lett, vol.18, issue.15, pp.4360-4363, 2008. ,
Alpha/Beta-hydrolase fold enzymes: structures, functions and mechanisms, Curr. Protein Pept. Sci, vol.1, issue.2, pp.209-235, 2000. ,
Molecular, functional and structural properties of the prolyl oligopeptidase of Trypanosoma cruzi (POP Tc80), which is required for parasite entry into mammalian cells, Biochem. J, pp.29-38, 2005. ,
The many blades of thepropeller proteins: conserved but versatile, Trends Biochem. Sci, issue.10, pp.553-561, 2011. ,
The interface between catalytic and hemopexin domains in matrix metalloproteinase-1 conceals a collagen binding exosite, J. Biol. Chem, issue.52, pp.45073-45082, 2011. ,
Crystal structure and functional analysis of the glutaminyl cyclase from Xanthomonas campestris, J. Mol. Biol, issue.3, pp.374-388, 2010. ,
Amidation of bioactive peptides: the structure of the lyase domain of the amidating enzyme, Structure, vol.17, issue.7, pp.965-973, 2009. ,
The structure of SHH in complex with HHIP reveals a recognition role for the Shh pseudo active site in signaling, Nat. Struct. Mol. Biol, issue.7, pp.691-697, 2009. ,
The first crystal structure of gluconolactonase important in the glucose secondary metabolic pathways, J. Mol. Biol, vol.384, issue.3, pp.604-614, 2008. ,
Tachylectin-2: crystal structure of a specific GlcNAc/GalNAcbinding lectin involved in the innate immunity host defense of the Japanese horseshoe crab Tachypleus tridentatus, EMBO J, vol.18, issue.9, pp.2313-2322, 1999. ,
Cytochrome cd1 structure: unusual haem environments in a nitrite reductase and analysis of factors contributing to betapropeller folds, J. Mol. Biol, vol.269, issue.3, pp.440-455, 1997. ,
Prolyl endopeptidase catalysis. A physical rather than a chemical step is rate-limiting, Biochem. J, pp.647-648, 1992. ,
A Trypanosoma cruzi-secreted 80 kDa proteinase with specificity for human collagen types I and IV, Biochem. J, pp.129-137, 1997. ,
Prolyl oligopeptidase of Trypanosoma brucei hydrolyzes native collagen, peptide hormones and is active in the plasma of infected mice, Microbes Infect, issue.6, pp.457-466, 2010. ,
URL : https://hal.archives-ouvertes.fr/mnhn-02047420
, Prolyl endopeptidases. Cell. Mol. Life Sci, vol.64, issue.3, pp.345-355, 2007.
Subsite specificity (S3, S2, S1', S2' and S3') of oligopeptidase B from Trypanosoma cruzi and Trypanosoma brucei using fluorescent quenched peptides: comparative study and identification of specific carboxypeptidase activity, Bio-Chem J, vol.373, pp.933-939, 2003. ,
Role of the oxyanion binding site and subsites S1 and S2 in the catalysis of oligopeptidase B, a novel target for antimicrobial chemotherapy, Biochemistry, issue.12, pp.4096-4106, 2002. ,
Construction of a 3D model of oligopeptidase B, a potential processing enzyme in prokaryotes, J. Mol. Graph. Model, vol.18, issue.1, pp.57-75, 2000. ,
Oligopeptidase B: a processing peptidase involved in pathogenesis, Biochimie, vol.90, issue.2, pp.336-344, 2008. ,
Substrate recognition properties of oligopeptidase B from Salmonella enterica serovar Typhimurium, J. Bacteriol, issue.12, pp.3329-3337, 2002. ,
A critical role for highly conserved Glu(610) residue of oligopeptidase B from Trypanosoma brucei in thermal stability, J. Biochem, issue.2, pp.201-211, 2010. ,
Purification and characterization of a new 120 kDa alkaline proteinase of Trypanosoma cruzi, Biochem. Biophys. Res. Commun, vol.187, issue.3, pp.1466-1473, 1992. ,
A cytosolic serine endopeptidase from Trypanosoma cruzi is required for the generation of Ca2+ signaling in mammalian cells, J. Cell. Biol, vol.136, issue.3, pp.609-620, 1997. ,
Identification of the reactive cysteine residues in oligopeptidase B from Trypanosoma brucei, FEBS Lett, issue.10, pp.2191-2196, 2005. ,
Modern analytical ultracentrifugation in protein science: a tutorial review, Protein Sci, vol.11, issue.9, pp.2067-2079, 2002. ,
Cell signalling and Trypanosoma cruzi invasion, Cell Microbiol, vol.4, issue.11, pp.701-711, 2002. ,
Chagas disease: 100 years after its discovery. A systemic review, Acta Trop, pp.5-13, 2010. ,
Molecular basis of mammalian cell invasion by Trypanosoma cruzi, An. Acad. Bras. Cienc, vol.78, issue.1, pp.87-111, 2006. ,
Breaking the wall: targeting of the endothelium by pathogenic bacteria, Nat. Rev. Microbiol, vol.8, issue.2, pp.93-104, 2010. ,
Trypanosoma cruzi prolyl oligopeptidase Tc80 is involved in nonphagocytic mammalian cell invasion by trypomastigotes, J. Biol. Chem, issue.50, pp.47078-47086, 2001. ,
URL : https://hal.archives-ouvertes.fr/hal-00086392
Bacterial manipulation of innate immunity to promote infection, Nat Rev Microbiol, vol.8, issue.2, pp.117-128, 2010. ,
URL : https://hal.archives-ouvertes.fr/hal-00553069
Matrix metalloproteinases in repair, Wound Repair Regen, vol.7, issue.6, pp.423-432, 1999. ,
The expression of REG 1A and REG 1B is increased during acute amebic colitis, Parasitol. Int, vol.60, issue.3, pp.296-300, 2011. ,
Newly visualized fibrillar collagen scaffolds dictate Entamoeba histolytica invasion route in the human colon, Cell. Microbiol, vol.14, issue.5, pp.609-621, 2012. ,
Injection of chemoattractants into normal cornea: a model of inflammation after alkali injury, Invest. Ophthalmol. Vis. Sci, vol.39, issue.9, pp.1744-1750, 1998. ,
A novel peptide CXCR ligand derived from extracellular matrix degradation during airway inflammation, Nat. Med, vol.12, issue.3, pp.317-323, 2006. ,
Structural requirements for interleukin-8 function identified by design of analogs and CXC chemokine hybrids, J. Biol. Chem, issue.23, pp.16075-16081, 1994. ,
A novel proteolytic cascade generates an extracellular matrix-derived chemoattractant in chronic neutrophilic inflammation, J. Immunol, issue.8, pp.5662-5669, 2008. ,
Increased activities of cardiac matrix metalloproteinases matrix metalloproteinase (MMP)-2 and MMP-9 are associated with mortality during the acute phase of experimental Trypanosoma cruzi infection, J. Infect. Dis, vol.197, issue.10, pp.1468-1476, 2008. ,
Automated parallel synthesis of a tetrahydroisoquinolin-based library: potential prolyl endopeptidase inhibitors, Bioorg. Med. Chem. Lett, vol.9, issue.3, pp.437-442, 1999. ,
Identification of inhibitors of an 80 kDa protease from Trypanosoma cruzi through the screening of a combinatorial peptide library, Chem. Pharm. Bull. (Tokyo), vol.47, issue.2, pp.194-198, 1999. ,
Synthesis and activity of pyrrolidinyl-and thiazolidinyl-dipeptide derivatives as inhibitors of the Tc80 prolyl oligopeptidase from Trypanosoma cruzi, Eur. J. Med. Chem, vol.35, issue.2, pp.257-266, 2000. ,
Comparison of the inhibition of human and Trypanosoma cruzi prolyl endopeptidases, Bioorg. Med. Chem, issue.6, pp.1719-1729, 2002. ,
Prolylisoxazoles: potent inhibitors of prolyloligopeptidase with antitrypanosomal activity, Bioorg. Med. Chem. Lett, vol.13, issue.17, pp.2875-2878, 2003. ,
URL : https://hal.archives-ouvertes.fr/mnhn-02867484
A novel T. cruzi heparin-binding protein promotes fibroblast adhesion and penetration of engineered bacteria and trypanosomes into mammalian cells, Cell, vol.67, issue.2, pp.411-421, 1991. ,
Lysosome recruitment and fusion are early events required for trypanosome invasion of mammalian cells, Cell, issue.7, pp.1117-1130, 1992. ,
Oligopeptidase B-dependent signaling mediates host cell invasion by Trypanosoma cruzi, EMBO J, issue.17, pp.4975-4986, 1998. ,
Proline-specific endopeptidase from Flavobacterium. Purification and properties, J. Biol. Chem, issue.10, pp.4786-4792, 1980. ,
An endo-acting prolinespecific oligopeptidase from Treponema denticola ATCC 35405: evidence of hydrolysis of human bioactive peptides, Infect. Immun, vol.62, issue.11, pp.4938-4947, 1994. ,
Transient up-regulation of a prolyl endopeptidase activity in the microsomal fraction of rat liver during postnatal development, Eur. J. Biochem, vol.252, issue.1, pp.178-183, 1998. ,
African trypanosome infections of the nervous system: parasite entry and effects on sleep and synaptic functions, Prog. Neurobiol, issue.2, pp.152-171, 2010. ,
Trypanosome hydrolases and the blood-brain barrier, Trends Parasitol, vol.18, issue.1, pp.17-19, 2002. ,
Blood-brain barrier traversal by African trypanosomes requires calcium signaling induced by parasite cysteine protease, J. Clin. Invest, issue.10, pp.2739-2747, 2006. ,
Protease activated receptor signaling is required for African trypanosome traversal of human brain microvascular endothelial cells, PLoS Negl. Trop. Dis, issue.7, p.479, 2009. ,
Matrix metalloproteinases, tissue inhibitors of MMPs and TACE in experimental cerebral malaria, Lab. Invest, vol.86, issue.9, pp.873-888, 2006. ,
Matrix metalloproteinase-9 and intercellular adhesion molecule 1 are powerful staging markers for human African trypanosomiasis, Trop. Med. Int. Health, vol.16, issue.1, pp.119-126, 2011. ,
Canine cerebral leishmaniasis: Potential role of matrix metalloproteinase-2 in the development of neurological disease, Vet. Immunol. Immunopathol, 2012. ,
Anaplasma phagocytophilum-Borrelia burgdorferi coinfection enhances chemokine, cytokine, and matrix metalloprotease expression by human brain microvascular endothelial cells, Clin. Vaccine Immunol, vol.14, issue.11, pp.1420-1424, 2007. ,
Changes in atrial natriuretic factor and plasma renin activity in dogs infected with Trypanosoma brucei, Parasitol. Res, issue.7, pp.553-556, 1992. ,
Unusual cleavage of peptidic hormones generated by trypanosome enzymes released in infested rat serum, Int. J. Pept. Protein Res, issue.2, pp.147-152, 1993. ,
,
, Bull. Soc. Pathol. Exot. Filiales, vol.81, issue.3, pp.468-476, 1988.
Pyroglutamyl peptidase type I from Trypanosoma brucei: a new virulence factor from African trypanosomes that de-blocks regulatory peptides in the plasma of infected hosts, Biochem. J, pp.635-645, 2006. ,
Post-proline cleaving enzyme. Purification of this endopeptidase by affinity chromatography, J. Biol. Chem, issue.23, pp.7593-7599, 1976. ,
Porcine muscle prolyl endopeptidase and its endogenous substrates, J. Biochem, vol.104, issue.1, pp.112-117, 1988. ,
Trypanosome-derived oligopeptidase B is released into the plasma of infected rodents, where it persists and retains full catalytic activity, Infect. Immun, vol.69, issue.4, pp.2757-2761, 2001. ,
Oligopeptidase B from Trypanosoma evansi. A parasite peptidase that inactivates atrial natriuretic factor in the bloodstream of infected hosts, J. Biol. Chem, issue.12, pp.10925-10937, 2005. ,
Purification and characterisation of a trypsin-like serine oligopeptidase from Trypanosoma congolense, Mol. Biochem. Parasitol, vol.102, issue.1, pp.145-155, 1999. ,
Dual role of signaling pathways leading to Ca(2+) and cyclic AMP elevation in host cell invasion by Trypanosoma cruzi, Infect. Immun, issue.12, pp.6602-6610, 2000. ,
Novel PI 3-kinase-dependent mechanisms of trypanosome invasion and vacuole maturation, J. Cell. Sci, vol.116, pp.3611-3622, 2003. ,
Role in host cell invasion of Trypanosoma cruzi-induced cytosolic-free Ca2+ transients, J. Exp. Med, vol.179, issue.3, pp.1017-1022, 1994. ,
Ca2+ signal induced by Trypanosoma cruzi metacyclic trypomastigote surface molecules implicated in mammalian cell invasion, Mol. Biochem. Parasitol, vol.73, issue.1-2, pp.285-289, 1995. ,
Infectivity of Trypanosoma cruzi strains is associated with differential expression of surface glycoproteins with differential Ca2+ signalling activity, Biochem. J, pp.505-511, 1998. ,
Müller-Esterl, W. Host cell invasion by Trypanosoma cruzi is potentiated by activation of bradykinin B(2) receptors, J. Exp. Med, vol.192, issue.9, pp.1289-1300, 2000. ,
The induction of Trypanosoma cruzi trypomastigote to amastigote transformation by low pH, Parasitology, pp.547-554, 1995. ,
Secretion by Trypanosoma cruzi of a hemolysin active at low pH, Mol. Biochem. Parasitol, vol.33, issue.3, pp.249-256, 1989. ,
The exit of Trypanosoma cruzi from the phagosome is inhibited by raising the pH of acidic compartments, J. Exp. Med, vol.171, issue.2, pp.401-413, 1990. ,
Specific human antibodies do not inhibit Trypanosoma cruzi oligopeptidase B and cathepsin B, and immunoglobulin G enhances the activity of trypomastigote-secreted oligopeptidase B. Microbes Infect, vol.7, pp.375-384, 2005. ,
URL : https://hal.archives-ouvertes.fr/mnhn-02070115
Characterisation of the antitrypanosomal activity of peptidyl alpha-aminoalkyl phosphonate diphenyl esters, Biochem. Pharmacol, issue.10, pp.1497-1504, 2000. ,
A trypanosome oligopeptidase as a target for the trypanocidal agents pentamidine, diminazene and suramin, FEBS Lett, issue.3, pp.251-256, 1998. ,
Trypanosoma brucei brucei oligopeptidase B null mutants display increased prolyl oligopeptidase-like activity, Mol. Biochem. Parasitol, vol.182, issue.1-2, pp.7-16, 2012. ,
URL : https://hal.archives-ouvertes.fr/hal-00675697
State of the art in African trypanosome drug discovery, Curr. Top. Med. Chem, issue.10, pp.1255-1274, 2011. ,
Oligopeptidase B deficient mutants of Leishmania major, Mol. Biochem. Parasitol, vol.175, issue.1, pp.49-57, 2011. ,
The oligopeptidase B of Leishmania regulates parasite enolase and immune evasion, J. Biol. Chem, vol.286, issue.1, pp.429-440, 2011. ,
Synthesis and activity of pyrrolidinyl-and thiazolidinyl-dipeptide derivatives as inhibitors of the Tc80 prolyl oligopeptidase from Trypanosoma cruzi, Eur. J. Med. Chem, vol.35, issue.2, pp.257-266, 2000. ,
Low molecular weight inhibitors of Prolyl Oligopeptidase: a review of compounds patented from, Expert Opin. Ther. Pat, vol.21, issue.7, pp.1023-1044, 2003. ,
Translational research on prolyl oligopeptidase inhibitors: the long road ahead, Expert Opin. Ther. Pat, vol.21, issue.7, pp.977-981, 2011. ,
Protamine: a unique and potent inhibitor of oligopeptidase B, J. Pept. Sci, vol.12, issue.1, pp.65-71, 2006. ,
Thousands of chemical starting points for antimalarial lead identification, Nature, issue.7296, pp.305-310, 2010. ,
Chemical genetics of Plasmodium falciparum, Nature, issue.7296, pp.311-315, 2010. ,
, Science, issue.5996, pp.1175-1180, 2010.
, Type I Collagen: Biological Functions, Synthesis and Medicinal Applications. Pinto, M.E.H.a.M, 2012.