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Goniomedines A and B: Unprecedented Bisindole Alkaloids Formed through Fusion of Two Indole Moieties via a Dihydropyran Unit

Abstract : Two novel bisindole alkaloids, goniomedines A (1) and B (2), possessing an unprecedented quebrachamine-pleioarpamine-type skeleton, in which indole moieties are fused via a dihydropyran unit, were isolated from the stem bark of Gonioma malagasy. The structures were elucidated by comprehensive analysis of MS and NMR spectroscopic data. Their absolute configurations were deduced following the comparison of experimental and theoretically calculated ECD spectra and through biogenetic considerations. Goniomedine B (2) exhibited moderate activity against Plasmodium falciparum.
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https://hal-mnhn.archives-ouvertes.fr/mnhn-02047389
Contributor : Philippe Grellier <>
Submitted on : Sunday, February 24, 2019 - 3:54:08 PM
Last modification on : Tuesday, April 20, 2021 - 6:01:24 PM

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Mehdi Beniddir, Marie-Thérèse Martin, Marie-Elise Tran Huu Dau, Philippe Grellier, Philippe Rasoanaivo, et al.. Goniomedines A and B: Unprecedented Bisindole Alkaloids Formed through Fusion of Two Indole Moieties via a Dihydropyran Unit. Organic Letters, American Chemical Society, 2012, 14 (16), pp.4162-4165. ⟨10.1021/ol301832t⟩. ⟨mnhn-02047389⟩

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