A New Xanthone from the Bark Extract of Rheedia acuminata and Antiplasmodial Activity of Its Major Compounds

Guillaume Marti (1) , Véronique Eparvier (2) , Marc Litaudon (2) , Philippe Grellier (3) , Francoise Guéritte (2)

1 PHARMA-DEV - Pharmacochimie et Biologie pour le Développement
2 ICSN - Institut de Chimie des Substances Naturelles
3 MCAM - Molécules de Communication et Adaptation des Micro-organismes

Bioassay-guided fractionation of the ethyl acetate bark extract of Rheedia acuminata led to the isolation of the new compound 1,5,6-trihydroxy-3-methoxy-7-geranyl-xanthone (1), together with four known compounds 2-5. These compounds were tested in vitro for their antiplasmodial activity on a chloroquine-resistant strain of Plasmodium falciparum (FcB1) and for their cytotoxicity against the human diploid embryonic lung cell line MRC-5.

Mots clés: cytotoxicity; antiplasmodial activity; Rheedia acuminata; Clusiaceae; xanthones

Domaines: Sciences du Vivant [q-bio]; Microbiologie et Parasitologie; Chimie organique

Guillaume Marti, Véronique Eparvier, Marc Litaudon, Philippe Grellier, Francoise Guéritte. A New Xanthone from the Bark Extract of Rheedia acuminata and Antiplasmodial Activity of Its Major Compounds. Molecules, 2010, 15 (10), pp.7106-7114. ⟨10.3390/molecules15107106⟩. ⟨mnhn-02047400⟩