A New Xanthone from the Bark Extract of Rheedia acuminata and Antiplasmodial Activity of Its Major Compounds

Abstract : Bioassay-guided fractionation of the ethyl acetate bark extract of Rheedia acuminata led to the isolation of the new compound 1,5,6-trihydroxy-3-methoxy-7-geranyl-xanthone (1), together with four known compounds 2-5. These compounds were tested in vitro for their antiplasmodial activity on a chloroquine-resistant strain of Plasmodium falciparum (FcB1) and for their cytotoxicity against the human diploid embryonic lung cell line MRC-5.
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Guillaume Marti, Véronique Eparvier, Marc Litaudon, Philippe Grellier, Francoise Guéritte. A New Xanthone from the Bark Extract of Rheedia acuminata and Antiplasmodial Activity of Its Major Compounds. Molecules, MDPI, 2010, 15 (10), pp.7106-7114. ⟨10.3390/molecules15107106⟩. ⟨mnhn-02047400⟩

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