The Ferroquine Antimalarial Conundrum: Redox Activation and Reinvasion Inhibition

Abstract : Metal health: Ferroquine is a ferrocene-based analogue of the antimalarial drug chloroquine. In addition to the primary mechanism of quinoline action, fluorescent probe studies in infected red blood cells show another mechanism is at work. It is based on the production of HO(·) in the acidic and oxidizing environment of the digestive vacuole of the malaria parasite and implies that, with ferroquine, reinvasion can be inhibited.
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Submitted on : Saturday, March 16, 2019 - 3:41:04 PM
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Faustine Dubar, Christian Slomianny, Jamal Khalife, Daniel Dive, Hadidjatou Kalamou, et al.. The Ferroquine Antimalarial Conundrum: Redox Activation and Reinvasion Inhibition. Angewandte Chemie International Edition, Wiley-VCH Verlag, 2013, 52 (30), pp.7690-7693. ⟨10.1002/anie.201303690⟩. ⟨mnhn-02070060⟩

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