The Ferroquine Antimalarial Conundrum: Redox Activation and Reinvasion Inhibition

Faustine Dubar (1) , Christian Slomianny (2) , Jamal Khalife (3) , Daniel Dive (3) , Hadidjatou Kalamou (3) , Yann Guerardel (4) , Philippe Grellier (5) , Christophe Biot (4)

1 UCCS - Unité de Catalyse et Chimie du Solide - UMR 8181
2 PHYCELL - Laboratoire de Physiologie Cellulaire : Canaux ioniques, inflammation et cancer - U 1003
3 CIIL - Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204
4 UGSF - Unité de Glycobiologie Structurale et Fonctionnelle UMR 8576
5 MCAM - Molécules de Communication et Adaptation des Micro-organismes

Metal health: Ferroquine is a ferrocene-based analogue of the antimalarial drug chloroquine. In addition to the primary mechanism of quinoline action, fluorescent probe studies in infected red blood cells show another mechanism is at work. It is based on the production of HO(·) in the acidic and oxidizing environment of the digestive vacuole of the malaria parasite and implies that, with ferroquine, reinvasion can be inhibited.

Keywords: reactive species; malaria; ferroquine; subcellular imaging; bioorganometallic chemistry

Domains: Chemical Sciences; Life Sciences [q-bio]; Life Sciences [q-bio]; Microbiology and Parasitology

Faustine Dubar, Christian Slomianny, Jamal Khalife, Daniel Dive, Hadidjatou Kalamou, et al.. The Ferroquine Antimalarial Conundrum: Redox Activation and Reinvasion Inhibition. Angewandte Chemie International Edition, 2013, 52 (30), pp.7690-7693. ⟨10.1002/anie.201303690⟩. ⟨mnhn-02070060⟩