Novel N-(4-Piperidinyl)benzamide Antimalarials with Mammalian Protein Farnesyltransferase Inhibitory Activity

Abstract : Protein farnesyltransferase of Plasmodium falciparum is a potential target in the treatment of malaria for which increased drug resistance is observed. The design, synthesis and evaluation of a series of N-(4-piperidinyl)benzamides is reported. The most potent compounds showed in vitro activity against the parasite at submicromolar concentrations.
Document type :
Journal articles
Complete list of metadatas

Cited literature [28 references]  Display  Hide  Download

https://hal-mnhn.archives-ouvertes.fr/mnhn-02070112
Contributor : Philippe Grellier <>
Submitted on : Saturday, March 16, 2019 - 5:58:21 PM
Last modification on : Thursday, March 21, 2019 - 1:00:53 AM
Long-term archiving on : Monday, June 17, 2019 - 3:46:24 PM

File

53_1324.pdf
Publisher files allowed on an open archive

Identifiers

Collections

Citation

A Ryckebusch, Pauline Gilleron, R Millet, R Houssin, A Lemoine, et al.. Novel N-(4-Piperidinyl)benzamide Antimalarials with Mammalian Protein Farnesyltransferase Inhibitory Activity. Chemical and Pharmaceutical Bulletin, Pharmaceutical Society of Japan, 2005, 53 (10), pp.1324-1326. ⟨10.1248/cpb.53.1324⟩. ⟨mnhn-02070112⟩

Share

Metrics

Record views

12

Files downloads

14