Novel Antimalarial Compounds Isolated in a Survey of Self-Medicative Behavior of Wild Chimpanzees in Uganda - Archive ouverte HAL Access content directly
Journal Articles Antimicrobial Agents and Chemotherapy Year : 2004

Novel Antimalarial Compounds Isolated in a Survey of Self-Medicative Behavior of Wild Chimpanzees in Uganda

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Abstract

Following a veterinary and behavioral survey of chimpanzees from a natural population in Uganda, leaf samples of Trichilia rubescens were collected because of the unusual method of ingestion observed. The methanolic crude extract of T. rubescens leaves exhibited significant antimalarial activity in vitro. Bioassay-directed fractionation provided two new limonoids, trichirubines A and B. A greater understanding of the role of secondary compounds in the primate diet may be helpful in recovering naturally occurring compounds of medicinal significance for human medicine.

Dates and versions

mnhn-02070132 , version 1 (20-12-2022)

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Sabrina Krief, M-T Martin, Philippe Grellier, John Kasenene, Thierry Sévenet. Novel Antimalarial Compounds Isolated in a Survey of Self-Medicative Behavior of Wild Chimpanzees in Uganda. Antimicrobial Agents and Chemotherapy, 2004, 48 (8), pp.3196-3199. ⟨10.1128/AAC.48.8.3196-3199.2004⟩. ⟨mnhn-02070132⟩
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