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Promoting healthspan and lifespan with caloric restriction in primates

Abstract : Recent data confirmed the efficiency of caloric restriction for promoting both healthspan and lifespan in primates, but also revealed potential adverse effects at the central level. This paper proposes perspectives and future directions to counterbalance potential adverse effects. Efforts should be made in combining nutrition-based clinical protocols with therapeutic and/or behavioral interventions to aim for synergetic effects, and therefore delay the onset of age-related diseases without adverse effects.
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Contributor : Brigitte Gaillard <>
Submitted on : Wednesday, April 24, 2019 - 11:25:03 AM
Last modification on : Saturday, June 6, 2020 - 3:25:38 AM

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Fabien Pifferi, Jérémy Terrien, Martine Perret, Jacques Epelbaum, Stéphane Blanc, et al.. Promoting healthspan and lifespan with caloric restriction in primates. Communications Biology, Nature Publishing Group, 2019, 2 (1), ⟨10.1038/s42003-019-0348-z⟩. ⟨hal-02108451⟩



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