B. A. Whitton and M. Potts, Ecology of Cyanobacteria II: Their Diversity in Space and Time, pp.1-13, 2012.

R. Kurmayer, L. Deng, and E. Entfellner, Role of toxic and bioactive secondary metabolites in colonization and bloom formation by filamentous cyanobacteria Planktothrix, Harmful Algae, vol.54, pp.69-86, 2016.

S. Mazard, A. Penesyan, M. Ostrowski, I. T. Paulsen, and S. Egan, Tiny Microbes with a Big Impact: The Role of Cyanobacteria and Their Metabolites in Shaping Our Future, Mar. Drugs, vol.14, p.97, 2016.

F. M. Buratti, M. Manganelli, S. Vichi, M. Stefanelli, S. Scardala et al., Cyanotoxins: Producing organisms, occurrence, toxicity, mechanism of action and human health toxicological risk evaluation, Arch. Toxicol, vol.91, 2017.

J. Humbert and A. Törökné, New Tools for the Monitoring of Cyanobacteria in Freshwater Ecosystems, Handbook of Cyanobacterial Monitoring and Cyanotoxin Analysis

J. Wiley, &. Sons, and L. , , pp.84-88, 2017.

N. Salmaso, C. Bernard, J. Humbert, R. Akçaalan, M. Albay et al., Basic Guide to Detection and Monitoring of Potentially Toxic Cyanobacteria, Handbook of Cyanobacterial Monitoring and Cyanotoxin Analysis

J. Wiley, &. Sons, and L. , , pp.46-69, 2017.

H. W. Paerl and T. G. Otten, Harmful Cyanobacterial Blooms: Causes, Consequences, and Controls, Microb. Ecol, vol.65, pp.995-1010, 2013.

G. Zanchett and E. C. Oliveira-filho, Cyanobacteria and cyanotoxins: From impacts on aquatic ecosystems and human health to anticarcinogenic effects, Toxins, vol.5, pp.1896-1917, 2013.

K. Tidgewell, B. R. Clark, and W. H. Gerwick, The natural products chemistry of cyanobacteria, Comprehensive Natural Products II Chemistry and Biology, vol.2, pp.141-188, 2010.

A. Shah, S. A. Akhter, N. Auckloo, B. N. Khan, I. Lu et al., Structural diversity, biological properties and applications of natural products from cyanobacteria. A review, vol.15, 2017.

Y. Mi, J. Zhang, S. He, and X. Yan, New peptides isolated from marine cyanobacteria, an overview over the past decade, Mar. Drugs, vol.15, 2017.

M. Wang, J. Zhang, S. He, and X. Yan, A review study on macrolides isolated from cyanobacteria, Mar. Drugs, vol.15, 2017.

G. E. Chlipala, S. Mo, and J. Orjala, Chemodiversity in freshwater and terrestrial cyanobacteria-A source for drug discovery, Curr. Drug Targets, vol.12, pp.1654-1673, 2011.

K. Sivonen, N. Leikoski, D. P. Fewer, and J. Jokela, Cyanobactins-ribosomal cyclic peptides produced by cyanobacteria, Appl. Microbiol. Biotechnol, vol.86, pp.1213-1225, 2010.

E. Dittmann, M. Gugger, K. Sivonen, and D. P. Fewer, Natural Product Biosynthetic Diversity and Comparative Genomics of the Cyanobacteria, Trends Microbiol, vol.23, pp.642-652, 2015.
URL : https://hal.archives-ouvertes.fr/pasteur-01381738

B. Pattanaik and P. Lindberg, Terpenoids and Their Biosynthesis in Cyanobacteria, Life, vol.5, pp.269-293, 2015.

R. Singh, P. Parihar, M. Singh, A. Bajguz, J. Kumar et al., Uncovering potential applications of cyanobacteria and algal metabolites in biology, agriculture and medicine: Current status and future prospects

J. S. Singh, A. Kumar, A. N. Rai, D. P. Singh, and . Cyanobacteria, A precious bio-resource in agriculture, ecosystem, and environmental sustainability, Front. Microbiol, vol.7, p.529, 2016.

W. H. Gerwick and A. M. Fenner, Drug Discovery from Marine Microbes, Microb. Ecol, vol.65, pp.800-806, 2013.

T. K. Shishido, A. Humisto, J. Jokela, L. Liu, M. Wahlsten et al., Antifungal compounds from cyanobacteria, Mar. Drugs, vol.13, pp.2124-2140, 2015.

S. Vijayakumar and M. Menakha, Pharmaceutical applications of cyanobacteria-A review, J. Acute Med, vol.5, pp.15-23, 2015.

O. Ciferri and O. Tiboni, The Biochemistry and Industrial Potential of Spirulina, Annu. Rev. Microbiol, vol.39, pp.503-526, 1985.

G. Abdulqader, L. Barsanti, and M. R. Tredici, Harvest of Arthrospira platensis from Lake Kossorom (Chad) and its household usage among the Kanembu, J. Appl. Phycol, vol.12, pp.493-498, 2000.

N. Lau, M. Matsui, A. A. Abdullah, and -. Cyanobacteria, Photoautotrophic Microbial Factories for the Sustainable Synthesis of Industrial Products, BioMed Res. Int, vol.754934, 2015.

E. M. Janssen and .. , Cyanobacterial peptides beyond microcystins-A review on co-occurrence, toxicity, and challenges for risk assessment, Water Res, vol.151, pp.488-499, 2019.

P. D. Boudreau, T. Byrum, W. T. Liu, P. C. Dorrestein, and W. H. Gerwick, Viequeamide A, a cytotoxic member of the kulolide superfamily of cyclic depsipeptides from a marine button cyanobacterium, J. Nat. Prod, vol.75, pp.1560-1570, 2012.

J. Komarek, J. Kastovsky, J. Mares, and J. R. Johansen, Taxonomic classification of cyanoprokaryotes (cyanobacterial genera) 2014, using a polyphasic approach, Preslia, vol.86, pp.295-335, 2014.

A. R. Soares, N. Engene, S. P. Gunasekera, J. M. Sneed, V. J. Paul et al., Antimicrobial Tetrahydroquinolinol from an Assemblage of Marine Cyanobacteria Containing a Novel Taxon, J. Nat. Prod, vol.78, pp.534-538, 2014.

O. B. Vining, R. A. Medina, E. A. Mitchell, P. Videau, D. Li et al., Depsipeptide companeramides from a panamanian marine cyanobacterium associated with the coibamide producer, J. Nat. Prod, vol.78, pp.413-420, 2015.

L. M. Nogle, R. T. Williamson, and W. H. Gerwick, Somamides A and B, two new depsipeptide analogues of dolastatin 13 from a Fijian cyanobacterial assemblage of Lyngbya majuscula and Schizothrix species, J. Nat. Prod, vol.64, pp.716-719, 2001.

A. Iwasaki, S. Sumimoto, O. Ohno, S. Suda, and K. Suenaga, Kurahamide, a cyclic depsipeptide analog of dolastatin 13 from a marine cyanobacterial assemblage of Lyngbya sp, Bull. Chem. Soc. Jpn, vol.87, pp.609-613, 2014.

G. G. Harrigan, W. Y. Yoshida, R. E. Moore, D. G. Nagle, P. U. Park et al., Isolation, structure determination, and biological activity of dolastatin 12 and Lyngbyastatin 1 from Lyngbya majuscula/Schizothrix calcicola cyanobacterial assemblages, J. Nat. Prod, vol.61, pp.1221-1225, 1998.

A. Pereira, Z. Cao, T. F. Murray, and W. H. Gerwick, Hoiamide A, a Sodium Channel Activator of Unusual Architecture from a Consortium of Two Papua New Guinea Cyanobacteria, Chem. Biol, vol.16, pp.893-906, 2009.

M. A. Graber and W. H. Gerwick, Kalkipyrone, a toxic gamma-pyrone from an assemblage of the marine cyanobacteria Lyngbya majuscula and Tolypothrix sp, J. Nat. Prod, vol.61, pp.677-680, 1998.

A. R. Pereira, Z. Cao, N. Engene, I. E. Soria-mercado, T. F. Murray et al., Palmyrolide A, an unusually stabilized neuroactive macrolide from Palmyra Atoll cyanobacteria, Org. Lett, vol.12, pp.4490-4493, 2010.

A. R. Pereira, L. Etzbach, N. Engene, R. Müller, and W. H. Gerwick, Molluscicidal metabolites from an assemblage of Palmyra Atoll cyanobacteria, J. Nat. Prod, vol.74, pp.1175-1181, 2011.

L. M. Nogle and W. H. Gerwick, Somocystinamide A, a Novel Cytotoxic Disulfide Dimer from a Fijian Marine Cyanobacterial Mixed Assemblage, Org. Lett, vol.4, pp.1095-1098, 2002.

R. T. Williamson, I. P. Singh, W. H. Gerwick, and . Taveuniamides, New chlorinated toxins from a mixed assemblage of marine cyanobacteria, Tetrahedron, vol.60, pp.7025-7033, 2004.

G. G. Harrigan, H. Luesch, W. Y. Yoshida, R. E. Moore, D. G. Nagle et al., Tumonoic acids, novel metabolites from a cyanobacterial assemblage of Lyngbya majuscula and Schizothrix calcicola, J. Nat. Prod, vol.62, pp.464-467, 1999.

N. Sitachitta, R. T. Williamson, and W. H. Gerwick, Yanucamides A and B, two new depsipeptides from an assemblage of the marine cyanobacteria Lyngbya majuscula and Schizothrix species, J. Nat. Prod, vol.63, pp.197-200, 2000.

N. J. Osborne, G. R. Shaw, and P. M. Webb, Health effects of recreational exposure to Moreton Bay, Australia waters during a Lyngbya majuscula bloom, Environ. Int, vol.33, pp.309-314, 2007.

N. J. Osborne and G. R. Shaw, Dermatitis associated with exposure to a marine cyanobacterium during recreational water exposure, BMC Dermatol, vol.8, issue.5, 2008.

N. Engene, R. Cameron-coates, and W. Gerwick, 16S Rrna gene heterogeneity in the filamentous marine cyanobacterial genus Lyngbya, J. Phycol, vol.46, pp.591-601, 2010.

N. Engene, E. C. Rottacker, J. Ka?tovský, T. Byrum, H. Choi et al., Moorea producens gen. nov., sp. nov. and Moorea bouillonii comb. nov., tropical marine cyanobacteria rich in bioactive secondary metabolites, Int. J. Syst. Evol. Microbiol, vol.62, pp.1171-1178, 2012.

N. Engene, V. J. Paul, T. Byrum, W. H. Gerwick, A. Thor et al., Five chemically rich species of tropical marine cyanobacteria of the genus Okeania gen. nov. (Oscillatoriales, Cyanoprokaryota), J. Phycol, vol.49, pp.1095-1106, 2013.

J. Komarek, E. Zapomelova, J. Smarda, J. Kopecky, E. Rejmankova et al., Polyphasic evaluation of Limnoraphis robusta, a water-bloom forming cyanobacterium from Lake Atitlan, Guatemala, with a description of Limnoraphis gen, Fottea, vol.13, pp.39-52, 2013.

G. B. Mcgregor and B. C. Sendall, Phylogeny and toxicology of Lyngbya wollei (Cyanobacteria, Oscillatoriales) from north-eastern Australia, with a description of Microseira gen. nov, J. Phycol, vol.51, pp.109-119, 2015.

N. Engene, H. Choi, E. Esquenazi, E. C. Rottacker, M. H. Ellisman et al., Underestimated biodiversity as a major explanation for the perceived rich secondary metabolite capacity of the cyanobacterial genus Lyngbya, Environ. Microbiol, vol.13, pp.1601-1610, 2011.

P. M. Shih, D. Wu, A. Latifi, S. D. Axen, D. P. Fewer et al., Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing, Proc. Natl. Acad. Sci, vol.110, pp.1053-1058, 2013.
URL : https://hal.archives-ouvertes.fr/pasteur-01389305

C. Médigue, A. Calteau, S. Cruveiller, M. Gachet, G. Gautreau et al., MicroScope-An integrated resource for community expertise of gene functions and comparative analysis of microbial genomic and metabolic data, Brief. Bioinform, 2017.

R. E. Moore, A. J. Blackman, C. E. Cheuk, J. S. Mynderse, G. K. Matsumoto et al., Absolute Stereochemistries of the Aplysiatoxins and Oscillatoxin A, J. Org. Chem, vol.49, pp.2484-2489, 1984.

J. H. Cardellina, F. Marner, and R. E. Moore, Seaweed dermatitis: Structure of Lyngbyatoxin A, Science, vol.204, pp.193-195, 1979.

I. Ohtani, R. E. Moore, and M. T. Runnegar, Cylindrospermopsin: A Potent Hepatotoxin from the Blue-Green Alga Cylindrospermopsis raciborskii, J. Am. Chem. Soc, vol.114, pp.7941-7942, 1992.

C. Mackintosh, K. A. Beattie, S. Klumpp, P. Cohen, and G. A. Codd, Cyanobacterial microcystin-LR is a potent and specific inhibitor of protein phosphatases 1 and 2A from both mammals and higher plants, FEBS Lett, vol.264, pp.187-192, 1990.

J. Jokela, L. M. Heinilä, T. K. Shishido, M. Wahlsten, D. P. Fewer et al., Production of high amounts of hepatotoxin nodularin and new protease inhibitors pseudospumigins by the brazilian benthic Nostoc sp, CENA543. Front. Microbiol, vol.8, 1963.

W. Stahl and H. Sies, Antioxidant activity of carotenoids. Mol. Asp. Med, vol.24, pp.345-351, 2003.

U. M. Lanfer-marquez, R. M. Barros, and P. Sinnecker, Antioxidant activity of chlorophylls and their derivatives, Food Res. Int, vol.38, pp.885-891, 2005.

S. Jain, G. Prajapat, M. Abrar, L. Ledwani, A. Singh et al., Cyanobacteria as efficient producers of mycosporine-like amino acids, J. Basic Microbiol, vol.57, pp.715-727, 2017.

C. Romay, J. Armesto, D. Remirez, R. González, N. Ledon et al., Antioxidant and anti-inflammatory properties of C-phycocyanin from blue-green algae, Inflamm. Res, vol.47, pp.36-41, 1998.

M. J. Balunas, M. F. Grosso, F. A. Villa, N. Engene, K. L. Mcphail et al., Coibacins A-D, antileishmanial marine cyanobacterial polyketides with intriguing biosynthetic origins, Org. Lett, vol.14, pp.3878-3881, 2012.

H. Choi, S. J. Mascuch, F. A. Villa, T. Byrum, M. E. Teasdale et al., Honaucins A-C, potent inhibitors of inflammation and bacterial quorum sensing: Synthetic derivatives and structure-activity relationships, Chem. Biol, vol.19, pp.589-598, 2012.

A. Kapu?cik, P. Hrouzek, M. Kuzma, S. Bártová, P. Novák et al., Novel Aeruginosin-865 from Nostoc sp. as a Potent Anti-inflammatory Agent, ChemBioChem, vol.14, pp.2329-2337, 2013.

L. A. Shaala, D. T. Youssef, K. L. Mcphail, and M. Elbandy, Malyngamide 4, a new lipopeptide from the Red Sea marine cyanobacterium Moorea producens (formerly Lyngbya majuscula), Phytochem. Lett, vol.6, pp.183-188, 2013.

C. Romay, R. Gonzalez, N. Ledon, D. Remirez, V. Rimbau et al., A Biliprotein with Antioxidant, Anti-Inflammatory and Neuroprotective Effects, vol.4, pp.207-216, 2003.

R. P. Rastogi, R. R. Sonani, and D. Madamwar, Cyanobacterial Sunscreen Scytonemin: Role in Photoprotection and Biomedical Research. Appl. Biochem. Biotechnol, vol.176, pp.1551-1563, 2015.

M. R. Prinsep, R. A. Thomson, M. L. West, and B. L. Wylie, Tolypodiol, an antiinflammatory diterpenoid from the cyanobacterium Tolypothrix nodosa, J. Nat. Prod, vol.59, pp.786-788, 1996.

T. Hayashi, K. Hayashi, M. Maeda, and I. Kojima, Calcium spirulan, an inhibitor of enveloped virus replication, from a blue-green alga Spirulina platensis, J. Nat. Prod, vol.59, pp.83-87, 1996.

M. Entzeroth, R. E. Moore, W. P. Niemczura, G. M. Patterson, and . Shoolery, alpha.-cyclodextrins from the cyanophyte Tolypothrix byssoidea, J. Org. Chem, vol.51, pp.5307-5310, 1986.

S. Thammana, H. Suzuki, E. Lobkovsky, J. Clardy, and Y. Shimizu, Isolation and structure assignment of an iminotetrasaccharide from a cultured filamentous cyanobacterium Anabaena sp, J. Nat. Prod, vol.69, pp.365-368, 2006.

K. Sueyoshi, M. Kaneda, S. Sumimoto, S. Oishi, N. Fujii et al., Odoamide, a cytotoxic cyclodepsipeptide from the marine cyanobacterium Okeania sp, Tetrahedron, vol.72, pp.5472-5478, 2016.

S. Mo, A. Krunic, S. D. Pegan, S. G. Franzblau, and J. Orjala, An antimicrobial guanidine-bearing sesterterpene from the cultured cyanobacterium Scytonema sp, J. Nat. Prod, vol.72, pp.2043-2045, 2009.

S. Y. Sung, L. T. Sin, T. T. Tee, S. T. Bee, A. R. Rahmat et al., Antimicrobial agents for food packaging applications, Trends Food Sci. Technol, vol.33, pp.110-123, 2013.

A. A. Abushelaibi, M. S. Shamsi, and H. S. Afifi, Use of antimicrobial agents in food processing systems. Recent Pat, Food. Nutr. Agric, vol.4, pp.2-7, 2012.

M. Sturdy, A. Krunic, S. Cho, S. Franzblau, and J. Orjala, Eucapsitrione, an anti-mycobacterium tuberculosis anthraquinone derivative from the cultured freshwater cyanobacterium Eucapsis sp, J. Nat. Prod, vol.73, pp.1441-1443, 2010.

L. M. Nogle and W. H. Gerwick, Isolation of four new cyclic depsipeptides, antanapeptins A-D, and dolastatin 16 from a Madagascan collection of Lyngbya majuscula, J. Nat. Prod, vol.65, pp.21-24, 2002.

I. Kosalec, D. Kremer, M. Locatelli, F. Epifano, S. Genovese et al., Anthraquinone profile, antioxidant and antimicrobial activity of bark extracts of Rhamnus alaternus, R. fallax, R. intermedia and R. pumila. Food Chem, vol.136, pp.335-341, 2013.

E. J. Yang, S. H. Kim, K. Y. Lee, and K. S. Song, Neuroprotective and anti-neuroinflammatory activities of anthraquinones isolated from Photorhabdus temperata culture broth, J. Microbiol. Biotechnol, vol.28, pp.12-21, 2018.

J. G. Park, S. C. Kim, Y. H. Kim, W. S. Yang, Y. Kim et al., Anti-Inflammatory and Antinociceptive Activities of Anthraquinone-2-Carboxylic Acid, Mediat. Inflamm, 2016.

G. C. Yen, P. D. Duh, and D. Y. Chuang, Antioxidant activity of anthraquinones and anthrone, Food Chem, vol.70, pp.437-441, 2000.

M. T. Reese, N. K. Gulavita, Y. Nakao, M. T. Hamann, W. Y. Yoshida et al., A Cytotoxic Depsipeptide from a Cephalaspidean, J. Am. Chem. Soc, vol.7863, pp.11081-11084, 1996.

S. Bunyajetpong, W. Y. Yoshida, N. Sitachitta, and K. Kaya, Trungapeptins A-C, cyclodepsipeptides from the marine cyanobacterium Lyngbya majuscula, J. Nat. Prod, vol.69, pp.1539-1542, 2006.

A. Tripathi, J. Puddick, M. R. Prinsep, P. P. Lee, and L. T. Tan, Hantupeptins B and C, cytotoxic cyclodepsipeptides from the marine cyanobacterium Lyngbya majuscula, Phytochemistry, vol.71, pp.307-311, 2010.

K. L. Malloy, Structure Elucidation of Biomedically Relevant Marine Cyanobacterial Natural Products, 2011.

E. Mevers, W. T. Liu, N. Engene, H. Mohimani, T. Byrum et al., Cytotoxic veraguamides, alkynyl bromide-containing cyclic depsipeptides from the marine cyanobacterium cf. Oscillatoria margaritifera, J. Nat. Prod, vol.74, pp.928-936, 2011.

R. Montaser, V. J. Paul, and H. Luesch, Pitipeptolides C-F, antimycobacterial cyclodepsipeptides from the marine cyanobacterium Lyngbya majuscula from Guam, Phytochemistry, vol.72, pp.2068-2074, 2011.

L. A. Salvador, J. S. Biggs, V. J. Paul, H. Luesch, and . Veraguamides-a-g, cyclic hexadepsipeptides from a dolastatin 16-producing cyanobacterium Symploca cf. hydnoides from Guam, J. Nat. Prod, vol.74, pp.917-927, 2011.

J. Almaliti, K. L. Malloy, E. Glukhov, C. Spadafora, M. Gutiérrez et al., Antiparasitic Cyclic Depsipeptides from the Marine Cyanobacterium Moorea producens, J. Nat. Prod, vol.80, pp.1827-1836, 2017.

A. Iwasaki, I. Shiota, S. Sumimoto, T. Matsubara, T. Sato et al., Cyclic Depsipeptides from an Okeania sp. Marine Cyanobacterium, J. Nat. Prod, vol.80, pp.1948-1952, 2017.

H. Luesch, R. Pangilinan, W. Y. Yoshida, R. E. Moore, and V. J. Paul, Pitipeptolides A and B, new cyclodepsipeptides from the marine cyanobacterium Lyngbya majuscula, J. Nat. Prod, vol.64, pp.304-307, 2001.

R. A. Medina, Biologically Active Cyclic Depsipeptides from Marine Cyanobacteria, p.160, 2009.

M. S. Costa, A. Rego, V. Ramos, T. B. Afonso, S. Freitas et al., The conifer biomarkers dehydroabietic and abietic acids are widespread in Cyanobacteria, Sci. Rep, 2016.

U. M. Acuña, J. Zi, J. Orjala, and E. J. Carcache-de-blanco, Ambiguine I Isonitrile from Fischerella ambigua Induces Caspase-Independent Cell Death in MCF-7 Hormone Dependent Breast Cancer Cells, Int. J. Cancer Res, vol.49, pp.1655-1662, 2015.

P. G. Becher and F. Jüttner, Insecticidal compounds of the biofilm-forming cyanobacterium Fischerella sp. (ATCC 43239), Environ. Toxicol, vol.20, pp.363-372, 2005.

P. G. Becher, S. Keller, G. Jung, R. D. Süssmuth, and F. Jüttner, Insecticidal activity of 12-epi-hapalindole J isonitrile, Phytochemistry, vol.68, pp.2493-2497, 2007.

E. Cagide, P. G. Becher, M. C. Louzao, B. Espiña, M. R. Vieytes et al., Hapalindoles from the cyanobacterium Fischerella: Potential sodium channel modulators, Chem. Res. Toxicol, vol.27, pp.1696-1706, 2014.

A. Etchegaray, E. Rabello, R. Dieckmann, D. H. Moon, M. F. Fiore et al., Algicide production by the filamentous cyanobacterium Fischerella sp. CENA 19, J. Appl. Phycol, vol.16, pp.237-243, 2004.

M. L. Hillwig, Q. Zhu, and X. Liu, Biosynthesis of Ambiguine Indole Alkaloids in Cyanobacterium Fischerella ambigua, ACS Chem. Biol, vol.9, pp.372-377, 2014.

M. L. Hillwig, H. A. Fuhrman, K. Ittiamornkul, T. J. Sevco, D. H. Kwak et al., Identification and characterization of a welwitindolinone alkaloid biosynthetic gene cluster in the stigonematalean cyanobacterium Hapalosiphon welwitschii, ChemBioChem, vol.15, pp.665-669, 2014.

U. Huber, R. E. Moore, and G. M. Patterson, Isolation of a nitrile-containing indole alkaloid from the terrestrial blue-green alga Hapalosiphon delicatulus, J. Nat. Prod, vol.61, pp.1304-1306, 1998.

H. Kim, D. Lantvit, C. H. Hwang, D. J. Kroll, S. M. Swanson et al., Indole alkaloids from two cultured cyanobacteria, Westiellopsis sp. and Fischerella muscicola, Bioorg. Med. Chem, vol.20, pp.5290-5295, 2012.

H. Kim, A. Krunic, D. Lantvit, Q. Shen, D. J. Kroll et al., Nitrile-containing fischerindoles from the cultured cyanobacterium Fischerella sp, Tetrahedron, vol.68, pp.3205-3209, 2012.

D. Klein, D. Daloze, J. C. Braekman, L. Hoffmann, and V. Demoulin, New hapalindoles from the cyanophyte Hapalosiphon laingii, J. Nat. Prod, vol.58, pp.1781-1785, 1995.

I. Koodkaew, Y. Sunohara, S. Matsuyama, and H. Matsumoto, Isolation of ambiguine D isonitrile from Hapalosiphon sp. and characterization of its phytotoxic activity, Plant Growth Regul, vol.68, pp.141-150, 2012.

M. L. Micallef, D. Sharma, B. M. Bunn, L. Gerwick, R. Viswanathan et al., Comparative analysis of hapalindole, ambiguine and welwitindolinone gene clusters and reconstitution of indole-isonitrile biosynthesis from cyanobacteria, BMC Microbiol, vol.14, p.213, 2014.

M. L. Micallef, P. M. Agostino, D. Sharma, R. Viswanathan, and M. C. Moffitt, Genome mining for natural product biosynthetic gene clusters in the Subsection V cyanobacteria, BMC Genom, vol.16, p.669, 2015.

S. Mo, A. Krunic, G. Chlipala, and J. Orjala, Antimicrobial ambiguine isonitriles from the cyanobacterium Fischerella ambigua, J. Nat. Prod, vol.72, pp.894-899, 2009.

S. Mo, A. Krunic, B. D. Santarsiero, S. G. Franzblau, and J. Orjala, Hapalindole-related alkaloids from the cultured cyanobacterium Fischerella ambigua, Phytochemistry, vol.71, pp.2116-2123, 2010.

R. E. Moore, C. Cheuk, G. M. Patterson, and . Hapalindoles, New Alkaloids from the Blue-Green Alga Hapalosiphon fontinalis, J. Am. Chem. Soc, vol.106, pp.6456-6457, 1984.

R. E. Moore, X. Q. Yang, G. M. Patterson, . Fontonamide, and A. Anhydrohapaloxindole, Two New Alkaloids from the Blue-Green Alga Hapalosiphon fontinalis, J. Org. Chem, vol.52, pp.3773-3777, 1987.

R. E. Moore, C. Cheuk, X. Q. Yang, G. M. Patterson, R. Bonjouklian et al., Antibacterial and Antimycotic Alkaloids from the Cyanophyte Hapalosiphon fontinalis, J. Org. Chem, vol.52, pp.1036-1043, 1987.

R. E. Moore, X. Q. Yang, G. M. Patterson, R. Bonjouklian, and T. A. Smitka, Hapalonamides and other oxidized hapalindoles from Hapalosiphon fontinalis, Phytochemistry, vol.28, pp.1565-1567, 1989.

A. Park, R. E. Moore, and G. M. Patterson, Fischerindole L, a new isonitrile from the terrestrial blue-green alga Fischerella muscicola, Tetrahedron Lett, vol.33, pp.3257-3260, 1992.

A. Raveh and S. Carmeli, Antimicrobial ambiguines from the cyanobacterium Fischerella sp. collected in Israel, J. Nat. Prod, vol.70, pp.196-201, 2007.

R. E. Schwartz, C. F. Hirsch, D. J. Pettibone, D. L. Zink, and J. P. Springer, Unusual Cyclopropane-Containing Hapalindolinones from a Cultured Cyanobacterium, J. Org. Chem, vol.52, pp.3704-3706, 1987.

T. A. Smitka, R. Bonjouklian, L. Doolin, N. D. Jones, J. B. Deeter et al., Ambiguine Isonitriles, Fungicidal Hapalindole-Type Alkaloids from Three Genera of Blue-Green Algae Belonging to the Stigonemataceae, J. Org. Chem, vol.57, pp.857-861, 1992.

K. Stratmann, R. E. Moore, G. M. Patterson, R. Bonjouklian, J. B. Deeter et al., Unusual Alkaloids from the Blue-Green Algae Hapalosiphon welwitschii and Westiella intricata. Relationship to Fischerindoles and Hapalinodoles, J. Am. Chem. Soc, vol.116, pp.9935-9942, 1994.

K. Walton, M. Gantar, P. D. Gibbs, M. C. Schmale, and J. P. Berry, Indole alkaloids from Fischerella inhibit vertebrate development in the zebrafish (Danio rerio) embryo model, Toxins, vol.6, pp.3568-3581, 2014.

C. P. Mason, K. R. Edwards, R. E. Carlson, J. Pignatello, F. K. Gleason et al., Isolation of Chlorine-Containing Antibiotic from the Freshwater Cyanobacterium Scytonema hofmanni, Science, vol.215, pp.400-402, 1982.

T. Ribeiro, F. Lemos, M. Preto, J. Azevedo, M. L. Sousa et al., Cytotoxicity of portoamides in human cancer cells and analysis of the molecular mechanisms of action, PLoS ONE, vol.12, 2017.

E. N. Zainuddin, R. Jansen, M. Nimtz, V. Wray, M. Preisitsch et al., Lyngbyazothrins A-D, antimicrobial cyclic undecapeptides from the cultured cyanobacterium Lyngbya sp, J. Nat. Prod, vol.72, pp.1373-1378, 2009.

M. P. Foster, G. P. Concepción, G. B. Caraan, C. M. Ireland, C. Bistratamides et al., New Oxazole-Containing Cyclic Hexapeptides Isolated from a Philippine Lissoclinum bistratum Ascidian, J. Org. Chem, vol.57, pp.6671-6675, 1992.

E. E. Ramsay, P. J. Hogg, and P. J. Dilda, Mitochondrial metabolism inhibitors for cancer therapy, Pharm. Res, vol.28, pp.2731-2744, 2011.

T. H. Bui, V. Wray, M. Nimtz, T. Fossen, M. Preisitsch et al., Balticidins A-D, antifungal hassallidin-like lipopeptides from the Baltic Sea cyanobacterium Anabaena cylindrica Bio33, J. Nat. Prod, vol.77, pp.1287-1296, 2014.

T. Neuhof, P. Schmieder, M. Seibold, and K. Preussel, Von Dö Hren, H. Hassallidin B-Second antifungal member of the Hassallidin family, Bioorg. Med. Chem. Lett, vol.16, pp.4220-4222, 2006.

T. Neuhof, P. Schmieder, K. Preussel, R. Dieckmann, H. Pham et al., Von Döhren, H. Hassallidin A, a Glycosylated Lipopeptide with Antifungal Activity from the Cyanobacterium Hassallia sp, J. Nat. Prod, vol.68, pp.695-700, 2005.

C. Pancrace, J. Jokela, N. Sassoon, C. Ganneau, M. Desnos-ollivier et al., Rearranged Biosynthetic Gene Cluster and Synthesis of Hassallidin in Planktothrix serta PCC 8927, ACS Chem. Biol, vol.12, pp.1796-1804, 2017.
URL : https://hal.archives-ouvertes.fr/pasteur-01535773

J. Vestola, T. K. Shishido, J. Jokela, D. P. Fewer, O. Aitio et al., Hassallidins, antifungal glycolipopeptides, are widespread among cyanobacteria and are the end-product of a nonribosomal pathway, Proc. Natl. Acad. Sci, vol.111, pp.1909-1917, 2014.

H. Choi, E. Mevers, T. Byrum, F. A. Valeriote, and W. H. Gerwick, Lyngbyabellins K-N from two Palmyra atoll collections of the marine cyanobacterium Moorea bouillonii, Eur. J. Org. Chem, pp.5141-5150, 2012.

B. Han, K. L. Mcphail, H. Gross, D. E. Goeger, S. L. Mooberry et al., Isolation and structure of five Lyngbyabellin derivatives from a Papua New Guinea collection of the marine cyanobacterium Lyngbya majuscula, Tetrahedron, vol.61, pp.11723-11729, 2005.

H. Luesch, W. Y. Yoshida, R. E. Moore, V. J. Paul, and S. L. Mooberry, Isolation, structure determination, and biological activity of Lyngbyabellin A from the marine cyanobacterium Lyngbya majuscula, J. Nat. Prod, vol.63, pp.611-615, 2000.

B. L. Marquez, K. S. Watts, A. Yokochi, M. A. Roberts, P. Verdier-pinard et al., Structure and absolute stereochemistry of hectochlorin, a potent stimulator of actin assembly, J. Nat. Prod, vol.65, pp.866-871, 2002.

K. E. Milligan, B. L. Marquez, R. T. Williamson, and W. H. Gerwick, Lyngbyabellin B, a toxic and antifungal secondary metabolite from the marine cyanobacterium Lyngbya majuscula, J. Nat. Prod, vol.63, pp.1440-1443, 2000.

A. V. Ramaswamy, C. M. Sorrels, and W. Gerwick, Cloning and Biochemical Characterization of the Hectochlorin Biosynthetic Gene Cluster from the Marine Cyanobacterium Lyngbya majuscula, J. Nat. Prod, vol.70, 1977.

P. G. Williams, H. Luesch, W. Y. Yoshida, R. E. Moore, and V. J. Paul, Continuing studies on the cyanobacterium Lyngbya sp.: Isolation and structure determination of 15-norlyngbyapeptin A and Lyngbyabellin D, J. Nat. Prod, vol.66, pp.595-598, 2003.

S. Matthew, L. A. Salvador, P. J. Schupp, V. J. Paul, and H. Luesch, Cytotoxic halogenated macrolides and modified peptides from the apratoxin-producing marine cyanobacterium Lyngbya bouillonii from Guam, J. Nat. Prod, vol.73, pp.1544-1552, 2010.

S. Adiv and S. Carmeli, Protease inhibitors from Microcystis aeruginosa bloom material collected from the Dalton reservoir, israel, J. Nat. Prod, vol.76, pp.2307-2315, 2013.

S. Gesner-apter and S. Carmeli, Three novel metabolites from a bloom of the cyanobacterium Microcystis sp, Tetrahedron, vol.64, pp.6628-6634, 2008.

M. Lifshits and S. Carmeli, Metabolites of Microcystis aeruginosa bloom material from Lake Kinneret, Israel, J. Nat. Prod, vol.75, pp.209-219, 2012.

F. J. Marner, R. E. Moore, K. Hirotsu, J. Clardy, B. et al., Epimeric Lipodipeptides from Lyngbya majuscula Gomont, J. Org. Chem, vol.42, pp.2815-2819, 1977.

D. C. Carter, R. E. Moore, J. S. Mynderse, W. P. Niemczura, and J. S. Todd, Structure of Majusculamide C, a Cyclic Depsipeptide from Lyngbya majuscula, J. Org. Chem, vol.49, pp.236-241, 1984.

R. E. Moore and M. Entzeroth, two cytotoxins from Lyngbya majuscula, Phytochemistry, vol.27, pp.3101-3103, 1988.

F. E. Koehn, R. E. Longley, and J. K. Reed, Microcolins a and b, new immunosuppressive peptides from the blue-green alga Lyngbya majuscula, J. Nat. Prod, vol.55, pp.613-619, 1992.

T. Meickle, S. Matthew, C. Ross, H. Luesch, and V. Paul, Bioassay-guided isolation and identification of desacetylmicrocolin B from Lyngbya cf. polychroa, Planta Med, vol.75, pp.1427-1430, 2009.

T. L. Simmons, L. M. Nogle, J. Media, F. A. Valeriote, S. L. Mooberry et al., Desmethoxymajusculamide C, a cyanobacterial depsipeptide with potent cytotoxicity in both cyclic and ring-opened forms, J. Nat. Prod, vol.72, pp.1011-1016, 2009.

L. T. Tan, B. P. Goh, A. Tripathi, M. G. Lim, G. H. Dickinson et al., Natural antifoulants from the marine cyanobacterium Lyngbya majuscula, Biofouling, vol.26, pp.685-695, 2010.

, Number of Deaths Due to HIV/AIDS, 2019.

D. K. Gupta, P. Kaur, S. T. Leong, L. T. Tan, M. R. Prinsep et al., Anti-Chikungunya viral activities of aplysiatoxin-related compounds from the marine cyanobacterium Trichodesmium erythraeum, Mar. Drugs, vol.12, pp.115-127, 2014.

G. E. Chlipala, M. Sturdy, A. Krunic, D. D. Lantvit, Q. Shen et al., Cylindrocyclophanes with proteasome inhibitory activity from the Cyanobacterium Nostoc sp, J. Nat. Prod, vol.73, pp.1529-1537, 2010.

B. N. Han, T. T. Liang, L. J. Keen, T. T. Fan, X. D. Zhang et al., Two Marine Cyanobacterial Aplysiatoxin Polyketides, Neo-debromoaplysiatoxin A and B, with K+Channel Inhibition Activity, Org. Lett, vol.20, pp.578-581, 2018.

R. P. Rastogi, D. Madamwar, and A. Incharoensakdi, Bloom Dynamics of Cyanobacteria and Their Toxins: Environmental Health Impacts and Mitigation Strategies, Front. Microbiol, vol.6, 1254.

G. E. Chlipala, P. H. Tri, N. Van-hung, A. Krunic, S. H. Shim et al., Nhatrangins A and B, aplysiatoxin-related metabolites from the marine cyanobacterium Lyngbya majuscula from Vietnam, J. Nat. Prod, vol.73, pp.784-787, 2010.

J. S. Mynderse, R. E. Moore, M. Kashiwagi, and T. R. Norton, Antileukemia activity in the Oscillatoriaceae: Isolation of debromoaplysiatoxin from Lyngbya, Science, vol.196, pp.538-540, 1977.

M. R. Boyd, K. R. Gustafson, J. B. Mcmahon, R. H. Shoemaker, B. R. O'keefe et al., Discovery of cyanovirin-N, a novel human immunodeficiency virus-inactivating protein that binds viral surface envelope glycoprotein gp120: Potential applications to microbicide development, Antimicrob. Agents Chemother, vol.41, pp.1521-1530, 1997.

B. Dey, D. L. Lerner, P. Lusso, M. R. Boyd, J. H. Elder et al., Multiple antiviral activities of cyanovirin-N: Blocking of human immunodeficiency virus type 1 gp120 interaction with CD4 and coreceptor and inhibition of diverse enveloped viruses, J. Virol, vol.74, pp.4562-4569, 2000.

E. Matei, R. Basu, W. Furey, J. Shi, C. Calnan et al., Structure and glycan binding of a new cyanovirin-N homolog, J. Biol. Chem, vol.291, pp.18967-18976, 2016.

K. Hayashi, T. Hayashi, and I. Kojima, A Natural Sulfated Polysaccharide, Calcium Spirulan, Isolated from Spirulina platensis: In vitro and ex Vivo Evaluation of Anti-Herpes simplex Virus and Anti-Human Immunodeficiency Virus Activities, AIDS Res. Hum. Retrovir, vol.12, pp.1463-1471, 1996.

J. Mader, A. Gallo, T. Schommartz, W. Handke, C. H. Nagel et al., Calcium spirulan derived from Spirulina platensis inhibits Herpes simplex virus 1 attachment to human keratinocytes and protects against herpes labialis, J. Allergy Clin. Immunol, vol.137, pp.197-203, 2016.

I. Wijesekara, R. Pangestuti, and S. K. Kim, Biological activities and potential health benefits of sulfated polysaccharides derived from marine algae, Carbohydr. Polym, vol.84, pp.14-21, 2011.

M. Baba, R. Pauwels, J. Balzarini, J. Arnout, J. Desmyter et al., Mechanism of inhibitory effect of dextran sulfate and heparin on replication of human immunodeficiency virus in vitro, Proc. Natl. Acad. Sci, vol.85, pp.6132-6136, 1988.

, World Health Organisation. Malaria. Available online, p.10, 2019.

H. Ogawa, A. Iwasaki, S. Sumimoto, M. Iwatsuki, A. Ishiyama et al., Isolation and Total Synthesis of Hoshinolactam, an Antitrypanosomal Lactam from a Marine Cyanobacterium, Org. Lett, vol.19, pp.890-893, 2017.

M. T. Davies-coleman, T. M. Dzeha, C. A. Gray, S. Hess, L. K. Pannell et al., Isolation of homodolastatin 16, a new cyclic depsipeptide from a Kenyan collection of Lyngbya majuscula, J. Nat. Prod, vol.66, pp.712-715, 2003.

B. J. Fennell, S. Carolan, G. R. Pettit, and A. Bell, Effects of the antimitotic natural product dolastatin 10, and related peptides, on the human malarial parasite Plasmodium falciparum, J. Antimicrob. Chemother, vol.51, pp.833-841, 2003.

G. G. Harrigan, H. Luesch, W. Y. Yoshida, R. E. Moore, D. G. Nagle et al., Symplostatin 1: A Dolastatin 10 Analogue from the Marine Cyanobacterium Symploca hydnoides, J. Nat. Prod, vol.61, pp.1075-1077, 1998.

G. G. Harrigan, H. Luesch, W. Y. Yoshida, R. E. Moore, D. G. Nagle et al., Symplostatin 2: A dolastatin 13 analogue from the marine cyanobacterium Symploca hydnoides, J. Nat. Prod, vol.62, pp.655-658, 1999.

H. Luesch, R. E. Moore, V. J. Paul, S. L. Mooberry, and T. H. Corbett, Isolation of dolastatin 10 from the marine cyanobacterium Symploca species VP642 and total stereochemistry and biological evaluation of its analogue symplostatin 1, J. Nat. Prod, vol.64, pp.907-910, 2001.

H. Luesch, W. Y. Yoshida, R. E. Moore, V. J. Paul, S. L. Mooberry et al., Symplostatin 3, a new dolastatin 10 analogue from the marine cyanobacterium Symploca sp. VP452, J. Nat. Prod, vol.65, pp.16-20, 2002.

S. S. Mitchell, D. J. Faulkner, K. Rubins, and F. D. Bushman, Dolastatin 3 and two novel cyclic peptides from a palauan collection of Lyngbya majuscula, J. Nat. Prod, vol.63, pp.279-282, 2000.

G. R. Pettit, The Dolastatins, Prog. Chem. Org. Nat. Prod, vol.70, pp.2-79, 1997.

E. Flahive and J. Srirangam, The Dolastatins: Novel Antitumor Agents from Dolabella auricularia, Anticancer Agents from Natural Products, p.600, 2005.

R. Bai, G. R. Pettit, and E. Hamel, Structure-activity studies with chiral isomers and with segments of the antimitotic marine peptide dolastatin 10, Biochem. Pharmacol, vol.40, pp.1859-1864, 1990.

B. W. Stewart and . Wild, The International Agency for Research on Cancer, 2014.

J. C. Mirsalis, J. Schindler-horvat, J. R. Hill, J. E. Tomaszewski, S. J. Donohue et al., Toxicity of dolastatin 10 in mice, rats and dogs and its clinical relevance, Cancer Chemother. Pharmacol, vol.44, pp.395-402, 1999.

J. A. Francisco, C. G. Cerveny, D. L. Meyer, B. J. Mixan, K. Klussman et al., vcMMAE, an anti-CD30-monomethyl auristatin E conjugate with potent and selective antitumor activity, Blood, vol.102, pp.1458-1465, 2003.

A. A. Rose, M. Biondini, R. Curiel, and P. M. Siegel, Targeting GPNMB with glembatumumab vedotin: Current developments and future opportunities for the treatment of cancer, Pharmacol. Ther, vol.179, pp.127-141, 2017.

J. J. Barchi, T. R. Norton, E. Furusawa, G. M. Patterson, and R. E. Moore, Identification of a cytotoxin from Tolypothrix byssoidea as tubercidin, Phytochemistry, vol.22, pp.2851-2852, 1983.

J. B. Stewart, V. Bornemann, J. L. Chen, R. E. Moore, F. R. Caplan et al., fungicidal nucleosides from blue green algae belonging to the Scytonemataceae, J. Antibiot, vol.61, pp.1048-1056, 1988.

S. L. Mooberry, K. Stratman, and R. E. Moore, Tubercidin stabilizes microtubules against vinblastine-induced depolymerization, a taxol-like effect, Cancer Lett, vol.96, pp.261-266, 1995.

K. Altmann, Microtubule-stabilizing agents: A growing class of important anticancer drugs, Curr. Opin. Chem. Biol, vol.5, pp.424-431, 2001.

B. Han, H. Gross, D. E. Goeger, S. L. Mooberry, and W. H. Gerwick, Aurilides B and C, cancer cell toxins from a Papua New Guinea collection of the marine cyanobacterium Lyngbya majuscula, J. Nat. Prod, vol.69, pp.572-575, 2006.

A. Tripathi, J. Puddick, M. R. Prinsep, M. Rottmann, and L. T. Tan, Lagunamides A and B: Cytotoxic and antimalarial cyclodepsipeptides from the marine cyanobacterium Lyngbya majuscula, J. Nat. Prod, vol.73, pp.1810-1814, 2010.

A. Tripathi, J. Puddick, M. R. Prinsep, M. Rottmann, K. P. Chan et al., Lagunamide C, a cytotoxic cyclodepsipeptide from the marine cyanobacterium Lyngbya majuscula, Phytochemistry, vol.72, pp.2369-2375, 2011.

P. G. Williams, W. Y. Yoshida, M. K. Quon, R. E. Moore, and V. J. Paul, The Structure of Palau'amide, a Potent Cytotoxin from a Species of the Marine Cyanobacterium Lyngbya, J. Nat. Prod, vol.66, pp.1545-1549, 2003.

E. H. Andrianasolo, H. Gross, D. Goeger, M. Musafija-girt, K. Mcphail et al., Isolation of swinholide A and related glycosylated derivatives from two field collections of marine cyanobacteria, Org. Lett, vol.7, pp.1375-1378, 2005.

A. Humisto, J. Jokela, L. Liu, M. Wahlsten, H. Wang et al., The swinholide biosynthesis gene cluster from a terrestrial cyanobacterium, Nostoc sp. strain UHCC 0450, Appl. Environ. Microbiol, vol.84, pp.2321-2338, 2018.

Y. Tao, P. Li, D. Zhang, E. Glukhov, L. Gerwick et al., Swinholide-Related Metabolites from a Marine Cyanobacterium cf. Phormidium sp, J. Org. Chem, vol.83, pp.3034-3046, 2018.

L. Oftedal, L. Myhren, J. Jokela, G. Gausdal, K. Sivonen et al., The lipopeptide toxins anabaenolysin A and B target biological membranes in a cholesterol-dependent manner, Biochim. Biophys. Acta Biomembr, vol.1818, pp.3000-3009, 2012.

J. Jokela, L. Oftedal, L. Herfindal, P. Permi, M. Wahlsten et al., Novel Cytolytic Lipopeptides from Benthic Anabaena Cyanobacteria, vol.7, 2012.

J. Y. Rao and N. Li, Microfilament Actin Remodeling as a Potential Target for Cancer Drug Development, Curr. Cancer Drug Targets, vol.4, pp.345-354, 2004.

K. Suenaga, T. Mutou, T. Shibata, T. Itoh, T. Fujita et al., Aurilide, a cytotoxic depsipeptide from the sea hare Dolabella auricularia: Isolation, structure determination, synthesis, and biological activity, Tetrahedron, vol.60, pp.8509-8527, 2004.

Y. Nakao, W. Y. Yoshida, Y. Takada, J. Kimura, L. Yang et al., Kulokekahilide-2, a cytotoxic depsipeptide from a cephalaspidean mollusk Philinopsis speciosa, J. Nat. Prod, vol.67, pp.1332-1340, 2004.

S. Carmeli and Y. Kashman, Structure of swinholide-a, a new macrolide from the marine sponge Theonella swinhoei, Tetrahedron Lett, vol.26, pp.511-514, 1985.

M. R. Bubb, I. Spector, A. D. Bershadsky, and E. D. Korn, Swinholide A is a microfilament disrupting marine toxin that stabilizes actin dimers and severs actin filaments, J. Biol. Chem, vol.270, pp.3463-3466, 1995.

T. Golakoti, I. Ohtani, G. M. Patterson, R. E. Moore, T. H. Corbett et al., Total Structures of Cryptophycins, Potent Antitumor Depsipeptides from the Blue-Green Alga Nostoc sp. Strain GSV 224, J. Am. Chem. Soc, vol.116, pp.4729-4737, 1994.

T. Golakoti, J. Ogino, C. E. Heltzel, T. L. Husebo, C. M. Jensen et al., Conformational Analysis, Chemical Stability Studies, and Antitumor Evaluation of the Cryptophycins. Isolation of 18 New Analogs from Nostoc sp. Strain GSV 224, Structure Determination, vol.117, pp.12030-12049, 1995.

G. V. Subbaraju, T. Golakoti, G. M. Patterson, and R. E. Moore, Three new cryptophycins from Nostoc sp. GSV 224, J. Nat. Prod, vol.60, pp.302-305, 1997.

C. D. Smith, X. Zhang, S. L. Mooberry, G. M. Patterson, and R. E. Moore, Cryptophycin: A new antimicrotubule agent active against drug-resistant cells, Cancer Res, vol.54, pp.3779-3784, 1994.

K. Stratmann, D. L. Burgoyne, R. E. Moore, G. M. Patterson, and C. D. Smith, Hapalosin, a Cyanobacterial Cyclic Depsipeptide with Multidrug-Resistance Reversing Activity, J. Org. Chem, vol.59, pp.7219-7226, 1994.

E. W. Schmidt, J. T. Nelson, D. A. Rasko, S. Sudek, J. A. Eisen et al., Patellamide A and C biosynthesis by a microcin-like pathway in Prochloron didemni, the cyanobacterial symbiont of Lissoclinum patella, Proc. Natl. Acad. Sci, vol.102, pp.7315-7320, 2005.

A. B. Williams and R. S. Jacobs, A marine natural product, patellamide D, reverses multidrug resistance in a human leukemic cell line, Cancer Lett, vol.71, pp.97-102, 1993.

M. R. Prinsep, F. R. Caplan, R. E. Moore, G. M. Patterson, and C. D. Smith, Tolyporphin, a Novel Multidrug Resistance Reversing Agent from the Blue-Green Alga Tolypothrix nodosa, J. Am. Chem. Soc, vol.114, pp.385-387, 1992.

M. R. Prinsep, G. M. Patterson, L. K. Larsen, and C. D. Smith, Further tolyporphins from the Blue-Green alga Tolypothrix nodosa, Tetrahedron, vol.51, pp.10523-10530, 1995.

A. K. Nanayakkara, C. A. Follit, G. Chen, N. S. Williams, P. D. Vogel et al., Targeted inhibitors of P-glycoprotein increase chemotherapeutic-induced mortality of multidrug resistant tumor cells

M. A. Ilies, C. T. Supuran, and A. Scozzafava, Therapeutic applications of serine protease inhibitors, Expert Opin. Ther. Pat, vol.12, pp.1181-1214, 2002.

M. Drag and G. S. Salvesen, Emerging principles in protease-based drug discovery, Nat. Rev. Drug Discov, vol.9, pp.690-701, 2010.

T. Dey, J. Kalita, S. Weldon, and C. Taggart, Proteases and Their Inhibitors in Chronic Obstructive Pulmonary Disease, J. Clin. Med, 2018.

C. Guay, M. Laviolette, and G. M. Tremblay, Targeting serine proteases in asthma, Curr. Top. Med. Chem, vol.6, pp.393-402, 2006.

M. R. Williams, T. Nakatsuji, J. A. Sanford, A. F. Vrbanac, and R. L. Gallo, Staphylococcus aureus Induces Increased Serine Protease Activity in Keratinocytes, J. Investig. Dermatol, vol.137, pp.377-384, 2017.

H. Lee, J. Ren, S. Nocadello, A. J. Rice, I. Ojeda et al., Identification of novel small molecule inhibitors against NS2B/NS3 serine protease from Zika virus, Antivir. Res, vol.139, pp.49-58, 2017.

J. Adams, The development of proteasome inhibitors as anticancer drugs, Cancer Cell, vol.5, pp.417-421, 2004.

J. E. Koblinski, M. Ahram, and B. F. Sloane, Unraveling the role of proteases in cancer, Clin. Chim. Acta, vol.291, pp.113-135, 2000.

J. Kos, A. Mitrovi?, and B. Mirkovi?, The current stage of cathepsin B inhibitors as potential anticancer agents, Future Med. Chem, vol.6, pp.1355-1371, 2014.

B. Bian, S. Mongrain, S. Cagnol, M. Langlois, J. Boulanger et al., Cathepsin B promotes colorectal tumorigenesis, cell invasion, and metastasis, Mol. Carcinog, vol.55, pp.671-687, 2016.

M. Garcia, N. Platet, E. Liaudet, V. Laurent, D. Derocq et al., Biological and clinical significance of cathepsin D in breast cancer metastasis, Stem Cells, vol.14, pp.642-650, 1996.

J. M. Lankelma, D. M. Voorend, T. Barwari, J. Koetsveld, A. H. Van-der-spek et al., Cathepsin L, target in cancer treatment?, Life Sci, vol.86, pp.225-233, 2010.

G. Leto, M. V. Sepporta, M. Crescimanno, C. Flandina, and F. M. Tumminello, Cathepsin L in metastatic bone disease: Therapeutic implications, Biol. Chem, vol.391, pp.655-664, 2010.

K. Fujii, K. Sivonen, K. Adachi, K. Noguchi, H. Sano et al., Comparative study of toxic and non-toxic cyanobacterial products: Novel peptides from toxic Nodularia spumigena AV1, Tetrahedron Lett, vol.38, pp.5525-5528, 1997.

A. R. Anas, T. Kisugi, T. Umezawa, F. Matsuda, M. R. Campitelli et al., Thrombin Inhibitors from the Freshwater Cyanobacterium Anabaena compacta, J. Nat. Prod, vol.75, pp.1546-1552, 2012.

D. P. Fewer, J. Jokela, L. Rouhiainen, M. Wahlsten, K. Koskenniemi et al., The non-ribosomal assembly and frequent occurrence of the protease inhibitors spumigins in the bloom-forming cyanobacterium Nodularia spumigena, Mol. Microbiol, vol.73, pp.924-937, 2009.

C. S. Gondi and J. S. Rao, Cathepsin B as a cancer target, Expert Opin. Ther. Targets, vol.17, pp.281-291, 2013.

S. Adiv, R. Ahronov-nadborny, and S. Carmeli, New aeruginazoles, a group of thiazole-containing cyclic peptides from Microcystis aeruginosa blooms, Tetrahedron, vol.68, pp.1376-1383, 2012.

F. H. Al-awadhi, L. A. Salvador, B. K. Law, V. J. Paul, and H. Luesch, Kempopeptin C, a novel marine-derived serine protease inhibitor targeting invasive breast cancer, Mar. Drugs, vol.15, 2017.

R. Banker and S. Carmeli, Inhibitors of serine proteases from a waterbloom of the cyanobacterium Microcystis sp, Tetrahedron, vol.55, pp.10835-10844, 1999.

D. Beresovsky, O. Hadas, A. Livne, A. Sukenik, A. Kaplan et al., Toxins and Biologically Active Secondary Metabolites of Microcystis sp. isolated from Lake Kinneret, Isr. J. Chem, vol.46, pp.79-87, 2006.

J. F. Blom, B. Bister, D. Bischoff, G. Nicholson, G. Jung et al., Oscillapeptin J, a new grazer toxin of the freshwater cyanobacterium Planktothrix rubescens, J. Nat. Prod, vol.66, pp.431-434, 2003.

R. Bonjouklian, T. A. Smitka, A. H. Hunt, J. L. Occolowitz, T. J. Perun et al., A90720A, a serine protease inhibitor isolated from a terrestrial blue-green alga Microchaete loktakensis, Tetrahedron, vol.52, pp.395-404, 1996.

H. Choi, S. K. Oh, W. Yih, J. Chin, H. Kang et al., Cyanopeptoline CB071: A cyclic depsipeptide isolated from the freshwater cyanobacterium Aphanocapsa sp, Chem. Pharm. Bull, vol.56, pp.1191-1193, 2008.

S. Elkobi-peer and S. Carmeli, New prenylated aeruginosin, microphycin, anabaenopeptin and micropeptin analogues from a Microcystis bloom material collected in Kibbutz Kfar Blum, Israel, Mar. Drugs, vol.13, pp.2347-2375, 2015.

K. Fujii, K. Sivonen, E. Naganawa, and K. Harada, ichi Non-toxic peptides from toxic cyanobacteria, Oscillatoria agardhii, Tetrahedron, vol.56, pp.725-733, 2000.

D. A. Gallegos, J. Saurí, R. D. Cohen, X. Wan, P. Videau et al., Cyanobacterial Protease Inhibitors from a Symploca sp. Cyanobacterium Collected in the Red Sea, J. Nat. Prod, vol.81, pp.1417-1425, 2018.

O. Grach-pogrebinsky, B. Sedmak, and S. Carmeli, Protease inhibitors from a Slovenian Lake Bled toxic waterbloom of the cyanobacterium Planktothrix rubescens, Tetrahedron, vol.59, pp.8329-8336, 2003.

S. P. Gunasekera, M. W. Miller, J. C. Kwan, H. Luesch, and V. J. Paul, Molassamide, a depsipeptide serine protease inhibitor from the marine cyanobacterium Dichothrix utahensis, J. Nat. Prod, vol.73, pp.459-462, 2010.

K. I. Harada, T. Mayumi, T. Shimada, K. Fujii, F. Kondo et al., Co-production of microcystins and aeruginopeptins by natural cyanobacterial bloom, Environ. Toxicol, vol.16, pp.298-305, 2001.

K. Ishida, H. Matsuda, M. Murakami, and K. Yamaguchi, Micropeptins 478-A and -B, plasmin inhibitors from the cyanobacterium Microcystis aeruginosa, J. Nat. Prod, vol.60, pp.184-187, 1997.

K. Ishida, H. Matsuda, and M. Murakami, Micropeptins 88-A to 88-F, chymotrypsin inhibitors from the cyanobacterium Microcystis aeruginosa (NIES-88), Tetrahedron, vol.54, pp.5545-5556, 1998.

K. Ishida, M. Murakami, H. Matsuda, and K. Yamaguchi, Micropeptin 90, a plasmin and trypsin inhibitor from the blue-green alga Microcystis aeruginosa (NIES-90), Tetrahedron Lett, vol.36, pp.3535-3538, 1995.

Y. Itou, K. Ishida, H. J. Shin, and M. Murakami, Oscillapeptins A to F, serine protease inhibitors from the three strains of Oscillatoria agardhii, Tetrahedron, vol.55, pp.6871-6882, 1999.

C. Jakobi, L. Oberer, C. Quiquerez, W. A. König, and J. Weckesser, Cyanopeptolin S, a sulfate-containing depsipeptide from a water bloom of Microcystis sp, FEMS Microbiol. Lett, vol.129, pp.129-133, 1995.

H. S. Kang, A. Krunic, and J. Orjala, Stigonemapeptin, an Ahp-containing depsipeptide with elastase inhibitory activity from the bloom-forming freshwater cyanobacterium Stigonema sp, J. Nat. Prod, vol.75, pp.807-811, 2012.

K. Kaya, T. Sano, K. A. Beattie, and G. A. Codd, Nostocyclin, a novel 3-amino-6-hydroxy-2-piperidone-containing cyclic depsipeptide from the cyanobacterium Nostoc sp, Tetrahedron Lett, vol.37, pp.6725-6728, 1996.

S. Kodani, S. Suzuki, K. Ishida, and M. Murakami, Five new cyanobacterial peptides from water bloom materials of Lake Teganuma (Japan), FEMS Microbiol. Lett, vol.178, pp.343-348, 1999.

J. C. Kwan, K. Taori, V. J. Paul, and H. Luesch, Lyngbyastatins 8-10, elastase inhibitors with cyclic depsipeptide scaffolds isolated from the marine cyanobacterium Lyngbya semiplena, Mar. Drugs, vol.7, pp.528-538, 2009.

M. Lifshits, E. Zafrir-ilan, A. Raveh, and S. Carmeli, Protease inhibitors from three fishpond water blooms of Microcystis spp, Tetrahedron, vol.67, pp.4017-4024, 2011.

R. G. Linington, D. J. Edwards, C. F. Shuman, K. L. Mcphail, T. Matainaho et al., Symplocamide A, a potent cytotoxin and chymotrypsin inhibitor from the marine cyanobacterium Symploca sp, J. Nat. Prod, vol.71, pp.22-27, 2008.

A. Lodin-friedman and S. Carmeli, Metabolites from Microcystis aeruginosa bloom material collected at a water reservoir near Kibbutz Hafetz Haim, Israel. J. Nat. Prod, vol.76, pp.1196-1200, 2013.

C. Martin, L. Oberer, M. Buschdtt, J. Weckesser, and . Cyanopeptolins, new depsipeptides from the cyanobacterium Microcystis sp. PCC 7806, J. Antibiot, vol.46, pp.1550-1556, 1993.

U. Matern, L. Oberer, R. A. Falchetto, M. Erhard, W. A. König et al., Scyptolin A and B, cyclic depsipeptides from axenic cultures of Scytonema hofmanni PCC 7110, Phytochemistry, vol.58, pp.1087-1095, 2001.

U. Matern, L. Oberer, M. Erhard, M. Herdmand, J. Weckesser et al., Phytochemistry, vol.64, pp.1061-1067, 2003.

S. Matthew, C. Ross, V. J. Paul, and H. Luesch, Pompanopeptins A and B, new cyclic peptides from the marine cyanobacterium Lyngbya confervoides, Tetrahedron, vol.64, pp.4081-4089, 2008.

K. Taori, S. Matthew, J. R. Rocca, V. J. Paul, and H. Luesch, Lyngbyastatins 5-7, potent elastase inhibitors from Floridian marine cyanobacteria, Lyngbya spp, J. Nat. Prod, vol.70, pp.1593-1600, 2007.

C. Mehner, D. Müller, S. Kehraus, S. Hautmann, M. Gütschow et al., New Peptolides from the Cyanobacterium Nostoc insulare as Selective and Potent Inhibitors of Human Leukocyte Elastase, ChemBioChem, vol.9, pp.2692-2703, 2008.

M. Murakami, S. Kodani, K. Ishida, H. Matsuda, and K. Yamaguchi, Micropeptin 103, a chymotrypsin inhibitor from the cyanobacterium Microcystis viridis (NIES-103), Tetrahedron Lett, vol.38, pp.3035-3038, 1997.

T. Okano, T. Sano, and K. Kaya, Micropeptin T-20, a novel phosphate-containing cyclic depsipeptide from the cyanobacterium Microcystis aeruginosa, Tetrahedron Lett, vol.40, pp.2379-2382, 1999.

T. Okino, M. Murakami, R. Haraguchi, H. Munekata, H. Matsuda et al., Micropeptins A and B, plasmin and trypsin inhibitors from the blue-green alga Microcystis aeruginosa, Tetrahedron Lett, vol.34, pp.8131-8134, 1993.

T. Okino, S. Qi, H. Matsuda, M. Murakami, and K. Yamaguchi, Nostopeptins A and B, elastase inhibitors from the cyanobacterium Nostoc minutum, J. Nat. Prod, vol.60, pp.158-161, 1997.

H. S. Okumura, B. Philmus, C. Portmann, and T. K. Hemscheidt, Homotyrosine-containing cyanopeptolins 880 and 960 and anabaenopeptins 908 and 915 from Planktothrix agardhii CYA 126/8, J. Nat. Prod, vol.72, pp.172-176, 2009.

A. Ploutno and S. Carmeli, Modified peptides from a water bloom of the cyanobacterium Nostoc sp, Tetrahedron, vol.58, pp.9949-9957, 2002.

A. Ploutno, M. Shoshan, and S. Carmeli, Three novel protease inhibitors from a natural bloom of the cyanobacterium Microcystis aeruginosa, J. Nat. Prod, vol.65, pp.973-978, 2002.

V. Reshef and S. Carmeli, Protease inhibitors from a water bloom of the cyanobacterium Microcystis aeruginosa, Tetrahedron, vol.57, pp.2885-2894, 2001.

T. Sano and K. Kaya, Oscillamide-Y, a Chymotrypsin Inhibitor from Toxic Oscillatoria agardhii, Tetrahedron Lett, vol.36, pp.5933-5936, 1995.

T. Sano and K. Kaya, Oscillapeptin G, a tyrosinase inhibitor from toxic Oscillatoria agardhii, J. Nat. Prod, vol.59, pp.90-92, 1996.

H. J. Shin, M. Murakami, H. Matsuda, K. Ishida, and K. Yamaguchi, Oscillapeptin, an elastase and chymotrypsin inhibitor from the cyanobacterium Oscillatoria agardhii (NIES-204), Tetrahedron Lett, vol.36, pp.5235-5238, 1995.

S. C. Stolze, E. Deu, F. Kaschani, N. Li, B. I. Florea et al., The antimalarial natural product symplostatin 4 is a nanomolar inhibitor of the food vacuole falcipains, Chem. Biol, vol.19, pp.1546-1555, 2012.

K. Taori, V. J. Paul, and H. Luesch, Kempopeptins A and B, serine protease inhibitors with different selectivity profiles from a marine cyanobacterium, Lyngbya sp, J. Nat. Prod, vol.71, pp.1625-1629, 2008.

T. Bladt, T. Kalifa-aviv, S. Ostenfeld-larsen, T. Carmeli, and S. , Micropeptins from Microcystis sp, Israel. Tetrahedron, vol.70, pp.936-943, 2014.

S. Tsukamoto, P. Painuly, K. A. Young, X. Yang, Y. Shimizu et al., Microcystilide A: A Novel Cell-Differentiation-Promoting Depsipeptide from Microcystis aeruginosa NO-15-1840, J. Am. Chem. Soc, vol.115, pp.11046-11047, 1993.

M. Vegman and S. Carmeli, Eight micropeptins from a Microcystis spp, Tetrahedron, vol.69, pp.10108-10115, 2013.

V. Elert, E. Oberer, L. Merkel, P. Huhn, T. Blom et al., Cyanopeptolin 954, a chlorine-containing chymotrypsin inhibitor of Microcystis aeruginosa NIVA Cya 43, J. Nat. Prod, vol.68, pp.1324-1327, 2005.

E. Zafrir-ilan and S. Carmeli, Eight novel serine proteases inhibitors from a water bloom of the cyanobacterium Microcystis sp, Tetrahedron, vol.66, pp.9194-9202, 2010.

K. Fujii, K. Sivonen, T. Nakano, and K. I. Harada, Structural elucidation of cyanobacterial peptides encoded by peptide synthetase gene in Anabaena species, Tetrahedron, vol.58, pp.6863-6871, 2002.

A. R. Pereira, A. J. Kale, A. T. Fenley, T. Byrum, H. M. Debonsi et al., The Carmaphycins: New Proteasome Inhibitors Exhibiting an ?,?-Epoxyketone Warhead from a Marine Cyanobacterium, ChemBioChem, vol.13, pp.810-817, 2012.

G. M. Lamonte, J. Almaliti, B. Bibo-verdugo, L. Keller, B. Y. Zou et al., Development of a Potent Inhibitor of the Plasmodium Proteasome with Reduced Mammalian Toxicity, J. Med. Chem, vol.60, pp.6721-6732, 2017.

M. Hirota, M. Ohmuraya, and H. Baba, The role of trypsin, trypsin inhibitor, and trypsin receptor in the onset and aggravation of pancreatitis, J. Gastroenterol, vol.41, pp.832-836, 2006.

K. Hilpert, J. Ackermann, D. W. Banner, A. Gast, K. Gubernator et al., Design and Synthesis of Potent and Highly Selective Thrombin Inhibitors, J. Med. Chem, vol.37, pp.3889-3901, 1994.

H. T. Bui, R. Jansen, H. T. Pham, S. Mundt, and . Carbamidocyclophanes, A-E, chlorinated paracyclophanes with cytotoxic and antibiotic activity from the Vietnamese cyanobacterium Nostoc sp, J. Nat. Prod, vol.70, pp.499-503, 2007.

J. L. Chen, R. E. Moore, and G. M. Patterson, Structures of Nostocyclophanes A-D, J. Org. Chem, vol.56, pp.4360-4364, 1991.

H. S. Kang, B. D. Santarsiero, H. Kim, A. Krunic, Q. Shen et al., Merocyclophanes A and B, antiproliferative cyclophanes from the cultured terrestrial Cyanobacterium Nostoc sp, Phytochemistry, vol.79, pp.109-115, 2012.

S. Luo, H. S. Kang, A. Krunic, G. E. Chlipala, G. Cai et al., Carbamidocyclophanes F and G with anti-Mycobacterium tuberculosis activity from the cultured freshwater cyanobacterium Nostoc sp, Tetrahedron Lett, vol.55, pp.686-689, 2014.

B. S. Moore, J. Chen, G. M. Patterson, and R. E. Moore, Structures of Cylindrocyclophanes A-F, Tetrahedron, vol.48, pp.3001-3006, 1992.

H. Nakamura, H. A. Hamer, G. Sirasani, and E. P. Balskus, Cylindrocyclophane biosynthesis involves functionalization of an unactivated carbon center, J. Am. Chem. Soc, vol.134, pp.18518-18521, 2012.

M. Preisitsch, K. Harmrolfs, H. T. Pham, S. E. Heiden, A. Füssel et al., Anti-MRSA-acting carbamidocyclophanes H-L from the Vietnamese cyanobacterium Nostoc sp. CAVN2, J. Antibiot, vol.68, pp.165-177, 2015.

T. Golakoti, W. Y. Yoshida, S. Chaganty, and R. E. Moore, Isolation and Structure Determination of Nostocyclopeptides A1 and A2 from the Terrestrial Cyanobacterium Nostoc sp. ATCC53789, J. Nat. Prod, vol.64, pp.54-59, 2001.

A. Krunic, A. Vallat, S. Mo, D. D. Lantvit, S. M. Swanson et al., Scytonemides A and B, cyclic peptides with 20S proteasome inhibitory activity from the cultured cyanobacterium Scytonema hofmanii, J. Nat. Prod, vol.73, pp.1927-1932, 2010.

S. H. Shim, G. Chlipala, and J. Orjala, Isolation and structure determination of a proteasome inhibitory metabolite from a culture of Scytonema hofmanni, J. Microbiol. Biotechnol, vol.18, pp.1655-1658, 2008.

A. Kobayashi, S. Kaiiyama, K. Inawaka, H. Kanzaki, and K. Kawazu, Nostodione A, a Novel Mitotic Spindle Poison* from a Blue-Green Alga Nostoc commune, Z. Nat. C, vol.49, pp.464-470, 1994.

J. Almaliti, B. Miller, H. Pietraszkiewicz, E. Glukhov, C. B. Naman et al., Exploration of the carmaphycins as payloads in antibody drug conjugate anticancer agents, Eur. J. Med. Chem, vol.161, pp.416-432, 2018.

L. A. Salvador-reyes and H. Luesch, Biological targets and mechanisms of action of natural products from marine cyanobacteria, Nat. Prod. Rep, vol.32, pp.478-503, 2015.

J. E. Bolden, M. J. Peart, and R. W. Johnstone, Anticancer activities of histone deacetylase inhibitors, Nat. Rev. Drug Discov, vol.5, pp.769-784, 2006.

K. Taori, V. J. Paul, and H. Luesch, Structure and activity of largazole, a potent antiproliferative agent from the Floridian marine cyanobacterium Symploca sp, J. Am. Chem. Soc, vol.130, pp.1806-1807, 2008.

Y. Liu, L. A. Salvador, S. Byeon, Y. Ying, J. C. Kwan et al., Anticolon Cancer Activity of Largazole, a Marine-Derived Tunable Histone Deacetylase Inhibitor, J. Pharmacol. Exp. Ther, vol.335, pp.351-361, 2010.

L. C. Wu, Z. S. Wen, Y. T. Qiu, X. Q. Chen, H. B. Chen et al., Largazole arrests cell cycle at g1 phase and triggers proteasomal degradation of E2F1 in lung cancer cells, ACS Med. Chem. Lett, vol.4, pp.921-926, 2013.

H. Zhou, S. Jiang, J. Chen, X. Ren, J. Jin et al., Largazole, an inhibitor of class I histone deacetylases, attenuates inflammatory corneal neovascularization, Eur. J. Pharmacol, vol.740, pp.619-626, 2014.

G. Poli, R. Di-fabio, L. Ferrante, V. Summa, and M. Botta, Largazole Analogues as Histone Deacetylase Inhibitors and Anticancer Agents: An Overview of Structure-Activity Relationships, vol.12, pp.1917-1926, 2017.

D. Ungermannova, S. J. Parker, C. G. Nasveschuk, W. Wang, B. Quade et al., Largazole and its derivatives selectively inhibit ubiquitin activating enzyme (E1), PLoS ONE, vol.7, 2012.

C. M. Pavlik, C. Y. Wong, S. Ononye, D. D. Lopez, N. Engene et al., Santacruzamate A, a potent and selective histone deacetylase inhibitor from the Panamanian marine cyanobacterium cf. Symploca sp, J. Nat. Prod, vol.76, pp.2026-2033, 2013.

T. Hanke, D. Merk, D. Steinhilber, G. Geisslinger, and M. Schubert-zsilavecz, Small molecules with anti-inflammatory properties in clinical development, Pharmacol. Ther, vol.157, pp.163-187, 2016.

P. M. Ridker and T. F. Lüscher, Anti-inflammatory therapies for cardiovascular disease, Eur. Heart J, vol.35, pp.1782-1791, 2014.

N. P. Rocha, A. S. De-miranda, and A. L. Teixeira, Insights into neuroinflammation in Parkinson's disease: From biomarkers to anti-inflammatory based therapies, BioMed Res. Int, 2015.

K. Ishida, Y. Okita, H. Matsuda, T. Okino, and M. Murakami, Aeruginosins, protease inhibitors from the cyanobacterium Microcystis aeruginosa, Tetrahedron, vol.55, pp.10971-10988, 1999.

K. Ishida, G. Christiansen, W. Y. Yoshida, R. Kurmayer, M. Welker et al., Biosynthesis and Structure of Aeruginoside 126A and 126B, Cyanobacterial Peptide Glycosides Bearing a 2-Carboxy-6-Hydroxyoctahydroindole Moiety, Chem. Biol, vol.14, pp.565-576, 2007.

H. Matsuda, T. Okino, M. Murakami, and K. Yamaguchi, Aeruginosins 102-A and B, New Thrombin Inhibitors from the Cyanobacterium Microcystis viridis (NIES-102), Tetrahedron, vol.52, pp.14501-14506, 1996.

S. Benedetti, F. Benvenuti, S. Pagliarani, S. Francogli, S. Scoglio et al., Antioxidant properties of a novel phycocyanin extract from the blue-green alga Aphanizomenon flos-aquae, Life Sci, vol.75, pp.2353-2362, 2004.

M. Kuddus, P. Singh, G. Thomas, and A. Al-hazimi, Recent developments in production and biotechnological applications of c-phycocyanin, BioMed Res. Int, 2013.

A. Patel, S. Mishra, and P. K. Ghosh, Antioxidant potential of C-phycocyanin isolated from cyanobacterial species Lyngbya, Phormidium and Spirulina spp, Indian J. Biochem. Biophys, vol.43, pp.25-31, 2006.

F. Garcia-pichel and R. W. Castenholz, Characterization and biological implications of scytonemin, a cyanobacterial sheath pigment, J. Phycol, vol.27, pp.395-409, 1991.

P. J. Proteau, W. H. Gerwick, F. Garcia-pichel, and R. Castenholz, The structure of scytonemin, an ultraviolet sunscreen pigment from the sheaths of cyanobacteria, Experientia, vol.49, pp.825-829, 1993.

T. Soule, V. Stout, W. D. Swingley, J. C. Meeks, and F. Garcia-pichel, Molecular genetics and genomic analysis of scytonemin biosynthesis in Nostoc punctiforme ATCC 29133, J. Bacteriol, vol.189, pp.4465-4472, 2007.

C. S. Stevenson, E. A. Capper, A. K. Roshak, B. Marquez, K. Grace et al., Scytonemin-a marine natural product inhibitor of kinases key in hyperproliferative inflammatory diseases, Inflamm. Res, vol.51, pp.112-114, 2002.

C. S. Stevenson, E. A. Capper, A. M. Roshak, B. Marquez, C. Eichman et al., The identification and characterization of the marine natural product scytonemin as a novel antiproliferative pharmacophore, J. Pharmacol. Exp. Ther, vol.303, pp.858-866, 2002.

K. L. Malloy, F. A. Villa, N. Engene, T. Matainaho, L. Gerwick et al., Malyngamide 2, an oxidized lipopeptide with nitric oxide inhibiting activity from a Papua New Guinea marine cyanobacterium, J. Nat. Prod, vol.74, pp.95-98, 2011.

M. Padrines, M. Wolf, A. Walz, and M. Baggiolini, Interleukin-8 processing by neutrophil elastase, cathepsin G and proteinase-3, FEBS Lett, vol.352, pp.231-235, 1994.

O. Wiedow and U. Meyer-hoffert, Neutrophil serine proteases: Potential key regulators of cell signalling during inflammation, J. Intern. Med, vol.257, pp.319-328, 2005.

C. T. Pham, Neutrophil serine proteases: Specific regulators of inflammation, Nat. Rev. Immunol, vol.6, pp.541-550, 2006.

R. N. Dubois, S. B. Abramson, L. Crofford, R. A. Gupta, L. S. Simon et al., Cyclooxygenase in biology and disease, FASEB J, vol.12, pp.1063-1073, 1998.

P. Patrignani and C. Patrono, Cyclooxygenase inhibitors: From pharmacology to clinical read-outs, Biochim. Biophys. Acta Mol. Cell Biol. Lipids, vol.1851, pp.422-432, 2015.

J. R. Vane and R. M. Botting, Anti-inflammatory drugs and their mechanism of action, Inflamm. Res, vol.47, pp.78-87, 1998.

B. Uttara, A. V. Singh, P. Zamboni, and R. T. Mahajan, Oxidative stress and neurodegenerative diseases: A review of upstream and downstream antioxidant therapeutic options, Curr. Neuropharmacol, vol.7, pp.65-74, 2009.

G. H. Kim, J. E. Kim, S. J. Rhie, and S. Yoon, The Role of Oxidative Stress in Neurodegenerative Diseases, Exp. Neurobiol, vol.24, 2015.

V. Rani, G. Deep, R. K. Singh, K. Palle, and U. C. Yadav, Oxidative stress and metabolic disorders: Pathogenesis and therapeutic strategies, Life Sci, vol.148, pp.183-193, 2016.

A. Baradaran, H. Nasri, and M. Rafieian-kopaei, Oxidative stress and hypertension: Possibility of hypertension therapy with antioxidants, J. Res. Med. Sci, vol.19, pp.358-367, 2014.

S. Li, H. Y. Tan, N. Wang, Z. J. Zhang, L. Lao et al., The role of oxidative stress and antioxidants in liver diseases, Int. J. Mol. Sci, vol.16, pp.26087-26124, 2015.

H. N. Siti, Y. Kamisah, and J. Kamsiah, The role of oxidative stress, antioxidants and vascular inflammation in cardiovascular disease (a review), Vascul. Pharmacol, vol.71, pp.40-56, 2015.

N. Wada, T. Sakamoto, and S. Matsugo, Multiple roles of photosynthetic and sunscreen pigments in cyanobacteria focusing on the oxidative stress, vol.3, pp.463-483, 2013.

J. Hirschberg and D. Chamovitz, Carotenoids in Cyanobacteria BT-The Molecular Biology of Cyanobacteria, The Molecular Biology of Cyanobacteria, pp.559-579, 1994.

E. P. Balskus and C. T. Walsh, The genetic and molecular basis for sunscreen biosynthesis in cyanobacteria, Science, vol.329, pp.1653-1656, 2010.

R. Waditee-sirisattha, H. Kageyama, W. Sopun, Y. Tanaka, and T. Takabe, Identification and upregulation of biosynthetic genes required for accumulation of Mycosporine-2-glycine under salt stress conditions in the halotolerant cyanobacterium Aphanothece halophytica, Appl. Environ. Microbiol, vol.80, pp.1763-1769, 2014.

S. Kosourov, G. Murukesan, J. Jokela, and Y. Allahverdiyeva, Carotenoid biosynthesis in calothrix sp. 336/3: Composition of carotenoids on full medium, during diazotrophic growth and after long-term H2photoproduction, Plant Cell Physiol, vol.57, pp.2269-2282, 2016.

F. H. Al-awadhi, B. K. Law, V. J. Paul, H. Luesch, and . Grassystatins-d-f, Potent Aspartic Protease Inhibitors from Marine Cyanobacteria as Potential Antimetastatic Agents Targeting Invasive Breast Cancer, vol.80, pp.2969-2986, 2017.

F. H. Al-awadhi, R. Ratnayake, V. J. Paul, and H. Luesch, Tasiamide F, a potent inhibitor of cathepsins D and E from a marine cyanobacterium, Bioorg. Med. Chem, vol.24, pp.3276-3282, 2016.

J. C. Kwan, E. A. Eksioglu, C. Liu, V. J. Paul, and H. Luesch, Grassystatins A-C from marine cyanobacteria, potent cathepsin E inhibitors that reduce antigen presentation, J. Med. Chem, vol.52, pp.5732-5747, 2009.

T. F. Molinski, K. A. Reynolds, and B. I. Morinaka, Symplocin A, a linear peptide from the bahamian cyanobacterium Symploca sp. configurational analysis of N,N-dimethylamino acids by chiral-phase HPLC of naphthacyl esters, J. Nat. Prod, vol.75, pp.425-431, 2012.

P. G. Williams, W. Y. Yoshida, R. E. Moore, V. J. Paul, and . Tasiamide, a cytotoxic peptide from the marine cyanobacterium Symploca sp, J. Nat. Prod, vol.65, pp.1336-1339, 2002.

P. G. Williams, W. Y. Yoshida, R. E. Moore, and V. J. Paul, The isolation and structure elucidation of tasiamide B, a 4-amino-3-hydroxy-5-phenylpentanoic acid containing peptide from the marine cyanobacterium Symploca sp, J. Nat. Prod, vol.66, pp.1006-1009, 2003.

E. Mevers, F. P. Haeckl, P. D. Boudreau, T. Byrum, P. C. Dorrestein et al., Lipopeptides from the tropical marine cyanobacterium Symploca sp, J. Nat. Prod, vol.77, pp.969-975, 2014.

K. Yamamoto, K. Okamoto, and T. Tsukuba, Cathepsin E: An Aspartic Protease with Diverse Functions and Biomedical Implications, In Encyclopedia of Cell Biology, vol.1, pp.681-690, 2015.

R. Vassar, B. D. Bennett, S. Babu-khan, S. Kahn, E. A. Mendiaz et al., ?-Secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE, Science, vol.286, pp.735-741, 1999.

N. Sitachitta and W. H. Gerwick, Grenadadiene and grenadamide, cyclopropyl-containing fatty acid metabolites from the marine cyanobacterium Lyngbya majuscula, J. Nat. Prod, vol.61, pp.681-684, 1998.

B. Han, K. L. Mcphail, A. Ligresti, V. Di-marzo, W. H. Gerwick et al., Fatty Acid Amides from a Papua New Guinea Collection of the Marine Cyanobacterium Lyngbya semiplena, J. Nat. Prod, vol.66, pp.1364-1368, 2003.

M. Gutiérrez, A. R. Pereira, H. M. Debonsi, A. Ligresti, V. Di-marzo et al., Cannabinomimetic lipid from a marine cyanobacterium, J. Nat. Prod, vol.74, pp.2313-2317, 2011.

E. Mevers, T. Matainaho, &. Allara, M. Di-marzo, V. Gerwick et al., Mooreamide A: A cannabinomimetic lipid from the marine cyanobacterium Moorea bouillonii, Lipids, vol.49, pp.1127-1132, 2014.

K. Kleigrewe, J. Almaliti, I. Y. Tian, R. B. Kinnel, A. Korobeynikov et al., Combining Mass Spectrometric Metabolic Profiling with Genomic Analysis: A Powerful Approach for Discovering Natural Products from Cyanobacteria, J. Nat. Prod, vol.78, pp.1671-1682, 2015.

O. Aizpurua-olaizola, I. Elezgarai, I. Rico-barrio, I. Zarandona, N. Etxebarria et al., Targeting the endocannabinoid system: Future therapeutic strategies, Drug Discov. Today, vol.22, pp.105-110, 2017.

S. Patel, M. N. Hill, J. F. Cheer, C. T. Wotjak, and A. Holmes, The endocannabinoid system as a target for novel anxiolytic drugs, Neurosci. Biobehav. Rev, vol.76, pp.56-66, 2017.