Age-associated evolution of plasmatic amyloid in mouse lemur primates: relationship with intracellular amyloid deposition

Maggie Roy (1) , Cécile Cardoso (2) , Olène Dorieux (2) , Carole Malgorn (3) , Stéphane Epelbaum (4, 5) , Fanny Petit (6) , Audrey Kraska (3) , Emmanuel Brouillet (3) , Benoit Delatour (5) , Martine Perret (7) , Fabienne Aujard (8) , Marc Dhenain (3)

1 IPMC - Institut de pharmacologie moléculaire et cellulaire
2 CEA - Commissariat à l'énergie atomique et aux énergies alternatives
3 LMN - Laboratoire des Maladies Neurodégénératives - UMR 9199
4 ARAMIS - Algorithms, models and methods for images and signals of the human brain
5 ICM - Institut du Cerveau = Paris Brain Institute
6 MIRCEN - Service MIRCEN
7 MAOAC - Mécanismes adaptatifs : des organismes aux communautés
8 MECADEV - Mécanismes Adaptatifs et Evolution

Alzheimer's disease (AD) is the most common age-related neurodegenerative disorder. Amyloid-β peptide (Aβ) deposition in the brain is one of its hallmarks and the measure of plasma Aβ is considered to be a biomarker for anti-amyloid drug efficacy in animal models of AD. However, age-associated plasmatic Aβ modulation in animal models is practically never addressed in the literature. Mouse lemur primates are used as a model of normal and AD-like cerebral aging. Here, we studied the effect of age on plasmatic Aβ in 58 mouse lemurs aged from 1 to 10 years. A subset of animals presented high plasmatic A β and the proportion of animals with high plasmatic Aβ was higher in aged animals as compared to young ones. Histological evaluation of the brain of some of these animals was carried out to assess extracellular and intracellular amyloid load. In aged lemurs, plasmatic A β was negatively correlated with the density of neurons accumulating deposits of Aβ.

Keywords: Microcebus murinus; Plasma; Amyloid; Alzheimer; Intracellular amyloid; Cerebral aging; Lemur

Domains: Life Sciences [q-bio]; Neurons and Cognition [q-bio.NC]; Life Sciences [q-bio]

Maggie Roy, Cécile Cardoso, Olène Dorieux, Carole Malgorn, Stéphane Epelbaum, et al.. Age-associated evolution of plasmatic amyloid in mouse lemur primates: relationship with intracellular amyloid deposition. Neurobiology of Aging, 2015, 36 (1), pp.149-156. ⟨10.1016/j.neurobiolaging.2014.07.017⟩. ⟨mnhn-02291873⟩