Age-associated evolution of plasmatic amyloid in mouse lemur primates: relationship with intracellular amyloid deposition

Maggie Roy; Cécile Cardoso; Olène Dorieux; Carole Malgorn; Stéphane Epelbaum; Fanny Petit; Audrey Kraska; Emmanuel Brouillet; Benoit Delatour; Martine Perret; Fabienne Aujard; Marc Dhenain

Age-associated evolution of plasmatic amyloid in mouse lemur primates: relationship with intracellular amyloid deposition

Maggie Roy ¹ Cécile Cardoso ² Olène Dorieux ² Carole Malgorn ³ Stéphane Epelbaum ^{4, 5} Fanny Petit ⁶ Audrey Kraska ³ Emmanuel Brouillet ³ Benoit Delatour ⁷ Martine Perret ⁸ Fabienne Aujard ⁹ Marc Dhenain ³

1 IPMC - Institut de pharmacologie moléculaire et cellulaire

2 CEA - Commissariat à l'énergie atomique et aux énergies alternatives

3 LMN - Laboratoire des Maladies Neurodégénératives - UMR 9199

MIRCEN - Service MIRCEN : DRF/JACOB, UP11 - Université Paris-Sud - Paris 11, CNRS - Centre National de la Recherche Scientifique : UMR 9199

4 ARAMIS - Algorithms, models and methods for images and signals of the human brain

UPMC - Université Pierre et Marie Curie - Paris 6, Inria de Paris, ICM - Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute

5 ICM - Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute

6 MIRCEN - Service MIRCEN

7 NAMC - Neurobiologie de l'apprentissage, de la mémoire et de la communication

8 MAOAC - Mécanismes adaptatifs : des organismes aux communautés

9 MECADEV - Mécanismes adaptatifs : des organismes aux communautés

Abstract : Alzheimer's disease (AD) is the most common age-related neurodegenerative disorder. Amyloid-β peptide (Aβ) deposition in the brain is one of its hallmarks and the measure of plasma Aβ is considered to be a biomarker for anti-amyloid drug efficacy in animal models of AD. However, age-associated plasmatic Aβ modulation in animal models is practically never addressed in the literature. Mouse lemur primates are used as a model of normal and AD-like cerebral aging. Here, we studied the effect of age on plasmatic Aβ in 58 mouse lemurs aged from 1 to 10 years. A subset of animals presented high plasmatic A β and the proportion of animals with high plasmatic Aβ was higher in aged animals as compared to young ones. Histological evaluation of the brain of some of these animals was carried out to assess extracellular and intracellular amyloid load. In aged lemurs, plasmatic A β was negatively correlated with the density of neurons accumulating deposits of Aβ .

Keywords : Amyloid Alzheimer Intracellular amyloid Cerebral aging Lemur Microcebus murinus Plasma

Document type :

Journal articles

Domain :

Life Sciences [q-bio] / Neurons and Cognition [q-bio.NC]

Life Sciences [q-bio]

Complete list of metadatas

https://hal-mnhn.archives-ouvertes.fr/mnhn-02291873
Contributor : Fabienne Aujard <>
Submitted on : Thursday, September 19, 2019 - 11:55:10 AM
Last modification on : Tuesday, October 1, 2019 - 1:29:14 AM

Age-associated evolution of plasmatic amyloid in mouse lemur primates: relationship with intracellular amyloid deposition

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Age-associated evolution of plasmatic amyloid in mouse lemur primates: relationship with intracellular amyloid deposition

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