Cilia-mediated Hedgehog signaling controls form and function in the mammalian larynx

Jacqueline Tabler 1 Maggie Rigney 1 Gordon Berman 2 Swetha Gopalakrishnan 3 Eglantine Heude 4, 3 Hadeel Adel Al-Lami 5 Basil Yannakoudakis 5 Rebecca Fitch 1 Christopher Carter 1 Steven Vokes 1 Karen Liu 5 Shahragim Tajbakhsh 3 S.E Roian Egnor 6 John Wallingford 1, *
* Corresponding author
1 Department of Molecular Biosciences [Austin, TX, USA]
2 Department of Biology [Atlanta, GA, USA]
3 Cellules Souches et Développement
4 AdV - Département Adaptations du vivant
5 Department of Craniofacial Development and Stem Cell Biology [London, UK]
6 Janelia Farm Research Campus
Abstract : Acoustic communication is fundamental to social interactions among animals, including humans. In fact, deficits in voice impair the quality of life for a large and diverse population of patients. Understanding the molecular genetic mechanisms of development and function in the vocal apparatus is thus an important challenge with relevance both to the basic biology of animal communication and to biomedicine. However, surprisingly little is known about the developmental biology of the mammalian larynx. Here, we used genetic fate mapping to chart the embryological origins of the tissues in the mouse larynx, and we describe the developmental etiology of laryngeal defects in mice with disruptions in cilia-mediated Hedgehog signaling. In addition, we show that mild laryngeal defects correlate with changes in the acoustic structure of vocalizations. Together, these data provide key new insights into the molecular genetics of form and function in the mammalian vocal apparatus.
Keywords : CPLANE Fuz cilia ciliopathy developmental biology larynx mouse neural crest stem cells
Document type :
Journal articles
Complete list of metadatas
https://hal-mnhn.archives-ouvertes.fr/mnhn-02295443
Contributor : Eglantine Heude <>
Submitted on : Tuesday, September 24, 2019 - 11:13:41 AM
Last modification on : Thursday, September 26, 2019 - 4:27:01 PM

Links full text

pubmedcentral

Identifiers

Collections

MNHN | UNIV-AG | INC-CNRS | COMUE-NORMANDIE | BOREA | UNICAEN | SORBONNE-UNIVERSITE | SU-SCIENCES

Citation

Jacqueline Tabler, Maggie Rigney, Gordon Berman, Swetha Gopalakrishnan, Eglantine Heude, et al.. Cilia-mediated Hedgehog signaling controls form and function in the mammalian larynx. eLife, eLife Sciences Publication, 2017, 6, pp.e19153. ⟨10.7554/eLife.19153⟩. ⟨mnhn-02295443⟩

Export

BibTeX TEI DC DCterms EndNote

Share

Metrics

Record views

17

Contact

support.ccsd.cnrs.fr
hal.support@ccsd.cnrs.fr
Logo CCSD