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Journal Articles Scientific Reports Year : 2018

Probing the origin of matching functional jaws: roles of Dlx5/6 in cranial neural crest cells

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Yorick Gitton
Eglantine Heude

Abstract

Gnathostome jaws derive from the first pharyngeal arch (PA1), a complex structure constituted by Neural Crest Cells (NCCs), mesodermal, ectodermal and endodermal cells. Here, to determine the regionalized morphogenetic impact of Dlx5/6 expression, we specifically target their inactivation or overexpression to NCCs. NCC-specific Dlx5/6 inactivation (NCC∆Dlx5/6) generates severely hypomorphic lower jaws that present typical maxillary traits. Therefore, differently from Dlx5/6 null-embryos, the upper and the lower jaws of NCC∆Dlx5/6 mice present a different size. Reciprocally, forced Dlx5 expression in maxillary NCCs provokes the appearance of distinct mandibular characters in the upper jaw. We conclude that: (1) Dlx5/6 activation in NCCs invariably determines lower jaw identity; (2) the morphogenetic processes that generate functional matching jaws depend on the harmonization of Dlx5/6 expression in NCCs and in distinct ectodermal territories. The co-evolution of synergistic opposing jaws requires the coordination of distinct regulatory pathways involving the same transcription factors in distant embryonic territories.

Dates and versions

mnhn-02295446 , version 1 (24-09-2019)

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Cite

Miki Shimizu, Nicolas Narboux-Nême, Yorick Gitton, Camille de Lombares, Anastasia Fontaine, et al.. Probing the origin of matching functional jaws: roles of Dlx5/6 in cranial neural crest cells. Scientific Reports, 2018, 8 (1), pp.14975. ⟨10.1038/s41598-018-33207-2⟩. ⟨mnhn-02295446⟩
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