1Cellules Souches et Développement (Département de Biologie du Développement et Cellules Souches - 25-28, rue du docteur Roux, 75724 Paris cedex 15 - France)
Abstract : In most vertebrates, the upper digestive tract is composed of muscularized jaws linked to the esophagus that permits food ingestion and swallowing. Masticatory and esophagus striated muscles (ESM) share a common cardiopharyngeal mesoderm (CPM) origin, however ESM are unusual among striated muscles as they are established in the absence of a primary skeletal muscle scaffold. Using mouse chimeras, we show that the transcription factors Tbx1 and Isl1 are required cell-autonomously for myogenic specification of ESM progenitors. Further, genetic loss-of-function and pharmacological studies point to MET/HGF signaling for antero-posterior migration of esophagus muscle progenitors, where Hgf ligand is expressed in adjacent smooth muscle cells. These observations highlight the functional relevance of a smooth and striated muscle progenitor dialogue for ESM patterning. Our findings establish a Tbx1-Isl1-Met genetic hierarchy that uniquely regulates esophagus myogenesis and identify distinct genetic signatures that can be used as framework to interpret pathologies arising within CPM derivatives.
https://hal-mnhn.archives-ouvertes.fr/mnhn-02295466
Contributor : Eglantine Heude
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Submitted on : Tuesday, November 26, 2019 - 2:48:28 PM
Last modification on : Wednesday, December 4, 2019 - 11:14:05 AM
