Binding properties of mono- and dimeric pyridine dicarboxamide ligands to human telomeric higher-order G-quadruplex structures

C. Saintomé; P. Alberti; N. Guinot; P. Lejault; J. Chatain; P. Mailliet; Jean-Francois Riou; A. Bugaut

Binding properties of mono- and dimeric pyridine dicarboxamide ligands to human telomeric higher-order G-quadruplex structures

C. Saintomé ¹ P. Alberti ¹ N. Guinot ¹ P. Lejault ¹ J. Chatain ¹ P. Mailliet ¹ Jean-Francois Riou ¹ A. Bugaut ¹

1 STRING - Structure et Instabilité des Génomes

Abstract : Here, we report on the in vitro binding properties of the known pyridine dicarboxamide G-quadruplex ligand 360A and a new dimeric analogue (360A)2A to human telomeric DNA higher-order G-quadruplex (G4) structures. This study points to original binding features never reported for G4 ligands, and reveals a greater eﬃciency for the dimeric ligand to displace RPA (a ssDNA binding protein involved in telomere replication) from telomeric DNA.

Document type :

Journal articles

Domain :

Chemical Sciences

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Submitted on : Tuesday, October 8, 2019 - 5:14:06 PM
Last modification on : Thursday, October 10, 2019 - 5:07:16 PM

Saintome ChemComm 2018.pdf

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Binding properties of mono- and dimeric pyridine dicarboxamide ligands to human telomeric higher-order G-quadruplex structures

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Binding properties of mono- and dimeric pyridine dicarboxamide ligands to human telomeric higher-order G-quadruplex structures

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