Binding properties of mono- and dimeric pyridine dicarboxamide ligands to human telomeric higher-order G-quadruplex structures

C. Saintomé 1 P. Alberti 1 N. Guinot 1 P. Lejault 1 J. Chatain 1 P. Mailliet 1 Jean-Francois Riou 1 A. Bugaut 1
1 STRING - Structure et Instabilité des Génomes
Abstract : Here, we report on the in vitro binding properties of the known pyridine dicarboxamide G-quadruplex ligand 360A and a new dimeric analogue (360A)2A to human telomeric DNA higher-order G-quadruplex (G4) structures. This study points to original binding features never reported for G4 ligands, and reveals a greater efficiency for the dimeric ligand to displace RPA (a ssDNA binding protein involved in telomere replication) from telomeric DNA.
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C. Saintomé, P. Alberti, N. Guinot, P. Lejault, J. Chatain, et al.. Binding properties of mono- and dimeric pyridine dicarboxamide ligands to human telomeric higher-order G-quadruplex structures. Chemical Communications, Royal Society of Chemistry, 2018, 54 (15), pp.1897-1900. ⟨10.1039/c7cc07048a⟩. ⟨mnhn-02308805⟩

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