Binding properties of mono- and dimeric pyridine dicarboxamide ligands to human telomeric higher-order G-quadruplex structures

C. Saintomé (1) , Patrizia Alberti (1) , N. Guinot (1) , P. Lejault (1) , J. Chatain (1) , P. Mailliet (1) , Jean-Francois Riou (1) , A. Bugaut (1)

1 STRING - Structure et Instabilité des Génomes

Here, we report on the in vitro binding properties of the known pyridine dicarboxamide G-quadruplex ligand 360A and a new dimeric analogue (360A)2A to human telomeric DNA higher-order G-quadruplex (G4) structures. This study points to original binding features never reported for G4 ligands, and reveals a greater efficiency for the dimeric ligand to displace RPA (a ssDNA binding protein involved in telomere replication) from telomeric DNA.

Domains: Chemical Sciences

C. Saintomé, Patrizia Alberti, N. Guinot, P. Lejault, J. Chatain, et al.. Binding properties of mono- and dimeric pyridine dicarboxamide ligands to human telomeric higher-order G-quadruplex structures. Chemical Communications, 2018, 54 (15), pp.1897-1900. ⟨10.1039/c7cc07048a⟩. ⟨mnhn-02308805⟩