Skip to Main content Skip to Navigation
Journal articles

Binding properties of mono- and dimeric pyridine dicarboxamide ligands to human telomeric higher-order G-quadruplex structures

C. Saintomé 1 Patrizia Alberti 1 N. Guinot 1 P. Lejault 1 J. Chatain 1 P. Mailliet 1 Jean-Francois Riou 1 A. Bugaut 1
1 STRING - Structure et Instabilité des Génomes
Abstract : Here, we report on the in vitro binding properties of the known pyridine dicarboxamide G-quadruplex ligand 360A and a new dimeric analogue (360A)2A to human telomeric DNA higher-order G-quadruplex (G4) structures. This study points to original binding features never reported for G4 ligands, and reveals a greater efficiency for the dimeric ligand to displace RPA (a ssDNA binding protein involved in telomere replication) from telomeric DNA.
Document type :
Journal articles
Complete list of metadata

Cited literature [22 references]  Display  Hide  Download
https://hal-mnhn.archives-ouvertes.fr/mnhn-02308805
Contributor : Jean-Francois Riou <>
Submitted on : Tuesday, October 8, 2019 - 5:14:06 PM
Last modification on : Tuesday, December 8, 2020 - 3:33:53 AM

File

Vignette du document
Saintome ChemComm 2018.pdf
Files produced by the author(s)

Identifiers

Collections

MNHN | CNRS | INC-CNRS | SORBONNE-UNIVERSITE | SU-SCIENCES | INSERM | SU-TI

Citation

C. Saintomé, Patrizia Alberti, N. Guinot, P. Lejault, J. Chatain, et al.. Binding properties of mono- and dimeric pyridine dicarboxamide ligands to human telomeric higher-order G-quadruplex structures. Chemical Communications, Royal Society of Chemistry, 2018, 54 (15), pp.1897-1900. ⟨10.1039/c7cc07048a⟩. ⟨mnhn-02308805⟩

Export

BibTeX TEI DC DCterms EndNote

Share

Metrics

Record views

147

Files downloads

237