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Journal articles
Binding properties of mono- and dimeric pyridine dicarboxamide ligands to human telomeric higher-order G-quadruplex structures
Abstract : Here, we report on the in vitro binding properties of the known pyridine dicarboxamide G-quadruplex ligand 360A and a new dimeric analogue (360A)2A to human telomeric DNA higher-order G-quadruplex (G4) structures. This study points to original binding features never reported for G4 ligands, and reveals a greater efficiency for the dimeric ligand to displace RPA (a ssDNA binding protein involved in telomere replication) from telomeric DNA.
Cited literature [22 references]
https://hal-mnhn.archives-ouvertes.fr/mnhn-02308805
Contributor : Jean-Francois Riou <>
Submitted on : Tuesday, October 8, 2019 - 5:14:06 PM
Last modification on : Tuesday, August 25, 2020 - 4:14:03 PM
Contributor : Jean-Francois Riou <>
Submitted on : Tuesday, October 8, 2019 - 5:14:06 PM
Last modification on : Tuesday, August 25, 2020 - 4:14:03 PM
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Saintome ChemComm 2018.pdf
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