H. M. Ahn, S. Kim, S. Hyun, S. R. Lim, H. Kim et al., Effects of the timing of a culture temperature reduction on the comprehensive metabolite profiles of Chlorella vulgaris, J. Appl. Phycol, vol.28, pp.2641-2650, 2016.

P. Allard, T. Péresse, J. Bisson, K. Gindro, V. C. Pham et al., Integration of molecular networking and In-Silico MS/MS fragmentation for natural products dereplication, Anal. Chem, vol.88, pp.3317-3323, 2016.

A. Baali, Y. , and A. , Polycyclic Aromatic Hydrocarbons (PAHs) and Their Influence to Some Aquatic Species, London: IntechOpen, 2019.

D. J. Beale, F. R. Pinu, K. A. Kouremenos, M. M. Poojary, V. K. Narayana et al., Review of recent developments in GC -MS approaches to metabolomics-based research, Metabolomics, vol.14, p.152, 2018.

S. Böcker and K. Dührkop, Fragmentation trees reloaded, J. Cheminform, vol.8, p.5, 2016.

J. Bohórquez, T. J. Mcgenity, S. Papaspyrou, E. García-robledo, A. Corzo et al., Different types of diatom-derived extracellular polymeric substances drive changes in heterotrophic bacterial communities from intertidal sediments, Front. Microbiol, vol.8, p.245, 2017.

M. F. Bourke, P. J. Marriott, R. N. Glud, H. Hasler-sheetal, M. Kamalanathan et al., Metabolism in anoxic permeable sediments is dominated by eukaryotic dark fermentation, Nat. Geosci, vol.10, pp.30-35, 2017.

M. A. Bromke, J. S. Sabir, F. A. Alfassi, N. H. Hajarah, S. A. Kabli et al., Metabolomic profiling of 13 diatom cultures and their adaptation to nitrate-limited growth conditions, PLoS One, vol.10, p.138965, 2015.

S. M. Budge and C. C. Parrish, Lipid biogeochemistry of plankton, settling matter and sediments in Trinity Bay, Org. Geochem, vol.29, pp.1547-1559, 1998.

J. G. Bundy, M. P. Davey, M. R. Viant, A. P. Davey, and M. R. Viant, Environmental metabolomics: a critical review and future perspectives, Metabolomics, vol.5, pp.3-21, 2009.

T. Cajka and O. Fiehn, Toward merging untargeted and targeted methods in mass spectrometry-based metabolomics and lipidomics, Anal. Chem, vol.88, pp.524-545, 2016.

M. C. Chambers, B. Maclean, R. Burke, D. Amodei, D. L. Ruderman et al., A cross-platform toolkit for mass spectrometry and proteomics, Nat. Biotechnol, vol.30, pp.918-920, 2012.

H. Chen, R. Yang, J. Chen, Q. Luo, X. Cui et al., 1-Octen-3-ol, a self-stimulating oxylipin messenger, can prime and induce defense of marine alga, BMC Plant Biol, vol.19, p.37, 2019.

H. C. Chung, O. O. Lee, Y. Huang, S. Y. Mok, and R. Kolter, Bacterial community succession and chemical profiles of subtidal biofilms in relation to larval settlement of the polychaete Hydroides elegans, ISME J, vol.4, pp.817-828, 2010.

E. Cointet, G. Wielgosz-collin, V. Méléder, and O. Gonçalves, Lipids in benthic diatoms: a new suitable screening procedure, Algal Res, vol.39, p.101425, 2019.
URL : https://hal.archives-ouvertes.fr/hal-02333689

J. Dalsgaard, M. St-john, G. Kattner, D. Müller-navarra, and W. Hagen, Fatty acid trophic markers in the pelagic marine environment, Adv. Mar. Biol, vol.46, pp.225-340, 2003.

A. W. Decho, Microbial biofilms in intertidal systems: an overview, Cont. Shelf Res, vol.20, pp.1257-1273, 2000.

V. M. Dembitsky, I. Dor, I. Shkrob, A. , and M. , Branched alkanes and other apolar compounds produced by the Cyanobacterium Microcoleus vaginatus from the Negev Desert, Russ. J. Bioorganic Chem, vol.27, pp.110-119, 2001.

G. D'ippolito, O. Iadicicco, G. Romano, and A. Fontana, Detection of short-chain aldehydes in marine organisms: the diatom Thalassiosira rotula, Tetrahedron Lett, vol.43, pp.6137-6140, 2002.

X. Domingo-almenara, J. Brezmes, M. Vinaixa, S. Samino, N. Ramirez et al., eRah: a computational tool integrating spectral deconvolution and alignment with quantification and identification of metabolites in GC-MSbased metabolomics, Anal. Bioanal. Chem, vol.88, pp.9821-9829, 2016.

A. D. Dove, J. Leisen, M. Zhou, J. J. Byrne, K. Lim-hing et al., Biomarkers of whale shark health: a metabolomic approach, PLoS One, vol.7, p.49379, 2012.

S. Elias and E. Banin, Multi-species biofilms: living with friendly neighbors, FEMS Microbiol. Rev, vol.36, pp.990-1004, 2012.

R. Fernandez-varela, G. Tomasi, and J. Christensen, An untargeted gas chromatography mass spectrometry metabolomics platform for marine polychaetes, J. Chromatogr. A, vol.1384, pp.133-141, 2015.

O. Fiehn, Metabolomics-the link between genotypes and phenotypes, Plant Mol. Biol, vol.48, pp.155-171, 2002.

H. Flemming, Biofilms: an emergent form of bacterial life, Nat. Publ. Gr, vol.14, pp.563-575, 2016.

H. C. Flemming and J. Wingender, The biofilm matrix, Nat. Rev. Microbiol, vol.8, pp.623-633, 2010.

F. Gaillard and P. Potin, Proteomics and metabolomics of marine organisms: current strategies and knowledge Fanny Gaillard and Philippe Potin abstract, Outstanding Marine Molecules: Chemistry, pp.457-472, 2014.

J. Gaubert, S. Greff, O. P. Thomas, and C. E. Payri, Metabolomic variability of four macroalgal species of the genus Lobophora using diverse approaches, Phytochemistry, vol.162, pp.165-172, 2019.
URL : https://hal.archives-ouvertes.fr/hal-02082160

J. Gillard, J. Frenkel, V. Devos, K. Sabbe, C. Paul et al., Metabolomics enables the structure elucidation of a diatom sex pheromone, Angew. Chemie Int. Ed, vol.52, pp.854-857, 2013.

J. Grimalt, R. Wit, P. Teixidor, A. , and J. , Lipid biogeochemistry of Phormidium and Microcoleus mats, Adv. Org. Geochem, vol.19, pp.509-530, 1992.

A. R. Hanlon, B. Bellinger, K. Haynes, G. Xiao, and T. A. Hofmann, Dynamics of extracellular polymeric substance (EPS) production and loss in an estuarine, diatom-dominated, microalgal biofilm over a tidal emersionimmersion period, Limnol. Oceanogr, vol.51, pp.79-93, 2006.

S. Haro, K. E. Brodersen, and S. Papaspyrou, Radiative energy budgets in a microbial mat under different irradiance and tidal conditions, Microb. Ecol, vol.77, pp.852-865, 2019.

C. Hubas, C. Passarelli, and D. M. Paterson, Microphytobenthic biofilms: composition and interactions, in Mudflat Ecology. Aquatic Ecology Series, vol.7, pp.63-90, 2018.
URL : https://hal.archives-ouvertes.fr/mnhn-02546153

C. Hubas, C. Sachidhanandam, H. Rybarczyk, H. V. Lubarsky, A. Rigaux et al., Bacterivorous nematodes stimulate microbial growth and exopolymer production in marine sediment microcosms, Mar. Ecol. Prog. Ser, vol.419, pp.85-94, 2010.

A. Ianora, A. Miralto, S. A. Poulet, Y. Carotenute, T. Buttino et al., Aldehyde suppression of copepod recruitment in blooms of a ubiquitous planktonic diatom, Nature, vol.429, pp.403-407, 2004.

A. Jahn and P. H. Nielsen, Extraction of extracellular polymeric substances (EPS) from biofilms using a cation exchange resin, Pergamon, vol.32, pp.157-164, 1995.

P. Juneau, A. Barnett, V. Méléder, C. Dupuy, and J. Lavaud, Combined effect of high light and high salinity on the regulation of photosynthesis in three diatom species belonging to the main growth forms of intertidal fl at inhabiting microphytobenthos, J. Exp. Mar. Bio. Ecol, vol.463, pp.95-104, 2015.

J. R. Kelly and R. E. Scheibling, Fatty acids as dietary tracers in benthic food webs, Mar. Ecol. Prog. Ser, vol.446, pp.1-22, 2012.

D. J. Kliebenstein, Secondary metabolites and plant / environment interactions: a view through Arabidopsis thaliana tinged glasses, Plant Cell Environ, vol.27, pp.675-684, 2004.

R. Kooke and J. J. Keurentjes, Multi-dimensional regulation of metabolic networks shaping plant development and performance, J. Exp. Bot, vol.63, pp.3353-3365, 2011.

S. Kraub and W. Vetter, Phytol and phytyl fatty acid esters: occurrence, concentrations and relevance, Eur. J. Lipid Sci. Technol, vol.120, p.1700387, 2018.

N. J. Kruger, M. A. Troncoso-ponce, and R. G. Ratcliffe, 1H NMR metabolite fingerprinting and metabolomic analysis of perchloric acid extracts from plant tissues, Nat. Protoc, vol.3, pp.1001-1012, 2008.

M. Kumar, U. Kuzhiumparambil, M. Pernice, Z. Jiang, and P. J. Ralph, Metabolomics: an emerging frontier of systems biology in marine macrophytes, Algal Res, vol.16, pp.76-92, 2016.

A. Lépinay, V. Turpin, F. Mondeguer, Q. Grandet-marchant, H. Capiaux et al., First insight on interactions between bacteria and the marine diatom Haslea ostrearia: algal growth and metabolomic fingerprinting, Algal Res, vol.31, pp.395-405, 2018.

H. Li, Y. Lu, J. Zheng, W. Yang, and J. Liu, Biochemical and genetic engineering of diatoms for polyunsaturated fatty acid biosynthesis, Mar. Drugs, vol.12, pp.153-166, 2014.

M. Liebeke and E. Puskás, Drying enhances signal intensities for global GC -MS metabolomics, Metabolites, vol.9, p.68, 2019.

F. Lippold, K. Dorp, M. Abraham, G. Hölzl, V. Wewer et al., Fatty acid phytyl ester synthesis in chloroplasts of Arabidopsis, Plant Cell, vol.24, 2001.

A. R. López-rosales, K. Ancona-canché, J. C. Chavarria-hernandez, F. Barahona-pérez, T. Toledano-thompson et al., Fatty acids, hydrocarbons and terpenes of nannochloropsis and nannochloris isolates with potential for biofuel production, Energies, vol.12, p.130, 2019.

G. Masse, S. T. Belt, S. J. Rowland, and M. Rohmer, Isoprenoid biosynthesis in the diatoms Rhizosolenia setigera (Brightwell) and Haslea ostrearia (Simonsen), Proc. Natl. Acad. Sci. U.S.A, vol.101, pp.4413-4418, 2004.

J. A. Mendiola, S. Santoyo, A. Cifuentes, G. Reglero, and F. J. Sen, Antimicrobial activity of sub-and supercritical CO 2 extracts of the green alga Dunaliella salina, J. Food Prot, vol.71, pp.2138-2143, 2008.

M. Nappo, S. Berkov, C. Codina, C. Avila, P. Messina et al., Metabolite profiling of the benthic diatom Cocconeis scutellum by GC-MS, 2009.

, J. Appl. Phycol, vol.21, pp.295-306

H. M. Parsons, D. R. Ekman, W. Collette, and M. R. Viant, Spectral relative standard deviation: a practical benchmark in metabolomics, Analyst, vol.134, pp.478-485, 2009.

C. Passarelli, T. Meziane, N. Thiney, D. Boeuf, B. Jesus et al., Seasonal variations of the composition of microbial biofilms in sandy tidal flats: focus of fatty acids, pigments and exopolymers, Estuar. Coast. Shelf Sci, vol.153, pp.29-37, 2015.
URL : https://hal.archives-ouvertes.fr/hal-01097244

C. Paul, M. A. Mausz, and G. Pohnert, A co-culturing/metabolomics approach to investigate chemically mediated interactions of planktonic organisms reveals influence of bacteria on diatom metabolism, Metabolomics, vol.9, pp.349-359, 2013.

R. G. Perkins, J. Lavaud, J. Serôdio, J. L. Mouget, P. Cartaxana et al., Vertical cell movement is a primary response of intertidal benthic biofilms to increasing light dose, Mar. Ecol. Prog. Ser, vol.416, pp.93-103, 2010.
URL : https://hal.archives-ouvertes.fr/hal-01095756

R. G. Perkins, G. J. Underwood, V. Brotas, G. C. Snow, B. Jesus et al., Responses of microphytobenthos to light: primary production and carbohydrate allocation over an emersion period, Mar. Ecol. Prog. Ser, vol.223, pp.101-112, 2001.

G. Pierre, M. Graber, F. Orvain, C. Dupuy, and T. Maugard, Biochemical characterization of extracellular polymeric substances extracted from an intertidal mudflat using a cation exchange resin, Biochem. Syst. Ecol, vol.38, pp.917-923, 2010.
URL : https://hal.archives-ouvertes.fr/hal-00652078

G. Pierre, J. M. Zhao, F. Orvain, C. Dupuy, G. L. Klein et al., Seasonal dynamics of extracellular polymeric substances (EPS) in surface sediments of a diatom-dominated intertidal mudflat, J. Sea Res, vol.92, pp.26-35, 2014.
URL : https://hal.archives-ouvertes.fr/hal-01070408

U. Riebesell, A. T. Revill, D. G. Holdsworth, and J. K. Volkman, The effects of varying CO 2 concentration on lipid composition and carbon isotope fractionation in Emiliania huxleyi, Geochim. Cosmochim. Acta, vol.64, pp.4179-4192, 2000.

U. Roessner, C. Wagner, J. Kopka, R. N. Trethewey, and L. Willmitzer, Simultaneous analysis of metabolites in potato tuber by gas chromatographymass spectrometry, Plant J, vol.23, pp.131-142, 2000.

J. Rontani, P. C. Bonin, and J. K. Volkman, Production of wax esters during aerobic growth of marine bacteria on isoprenoid compounds, Appl. Environ. Microbiol, vol.65, pp.221-230, 1999.

J. Rontani and J. K. Volkman, Phytol degradation products as biogeochemical tracers in aquatic environments, Org. Geochem, vol.34, pp.1-35, 2003.

J. F. Rontani and J. K. Volkman, Lipid characterization of coastal hypersaline cyanobacterial mats from the Camargue (France), Org. Geochem, vol.36, pp.251-272, 2005.

S. A. Santos, C. Vilela, C. S. Freire, M. H. Abreu, S. M. Rocha et al., Chlorophyta and Rhodophyta macroalgae: a source of health promoting phytochemicals, Food Chem, vol.183, pp.122-128, 2015.

P. Shannon, A. Markiel, O. Ozier, N. S. Baliga, J. T. Wang et al., Cytoscape: a software environment for integrated models of biomolecular interaction networks, Genome Res, vol.13, pp.2498-2504, 2003.

J. Shiea, S. Brassell, and D. Ward, Comparative analysis of extractable lipids in hot spring microbial mats and their component photosynthetic bacteria, Org. Geochem, vol.17, pp.309-319, 1991.

D. J. Smith and G. J. Underwood, Exopolymer production by intertidal epipelic diatoms, Limnol. Oceanogr, vol.43, pp.1578-1591, 1998.

E. M. Sogin, E. Puskás, N. Dubilier, and M. Liebeke, Marine metabolomics: measurement of metabolites in seawater by gas chromatography mass spectrometry. bioRxiv, 2019.

D. Sorigué, B. Légeret, S. Cuiné, P. Morales, B. Mirabella et al., Microalgae synthesize hydrocarbons from long-chain fatty acids via a light-dependent pathway 1, Plant Physiol, vol.171, pp.2393-2405, 2016.

L. J. Stal, Microphytobenthos, their extracellular polymeric substances, and the morphogenesis of intertidal sediments, Geomicrobiol. J, vol.20, pp.463-478, 2003.

V. Stonik and I. Stonik, Low-molecular-weight metabolites from diatoms: structures. Biological roles and biosynthesis, Mar. Drugs, vol.13, pp.3672-3709, 2015.

I. W. Sutherland, EPS -a complex mixture, The Perfect Slime: Microbial Extracellular Polymeric Substances (EPS), pp.15-24, 2017.

E. Takahashi, J. Ledauphin, D. Goux, and F. Orvain, Optimising extraction of extracellular polymeric substances (EPS) from benthic diatoms: comparison of the efficiency of six EPS extraction methods, Mar. Freshw. Res, vol.60, pp.1201-1210, 2009.
URL : https://hal.archives-ouvertes.fr/hal-02472061

N. Toupoint, V. Mohit, I. Linossier, N. Bourgougnon, F. Olivier et al., Effect of biofilm age on settlement of Mytilus edulis, Biofouling, vol.28, pp.985-1001, 2012.
URL : https://hal.archives-ouvertes.fr/hal-00857492

G. J. Underwood and J. Kromkamp, Primary production by phytoplankton and microphytobenthos in Estuaries, Advances in Ecological Research Estuaries, pp.93-139, 1999.

G. J. Underwood and M. D. Paterson, The importance of extracellular carbohydrate production by marine epipelic diatoms, Adv. Bot. Res, vol.40, pp.183-240, 2003.

H. Van-den-dool and P. D. Kratz, A generalization of the retention index system including linear temperature programmed gas-liquid partition chromatography, J. Chromatogr, vol.11, p.80947, 1963.

J. Wang, Z. Tan, J. Peng, Q. Qiu, L. et al., The behaviors of microplastics in the marine environment, Mar. Environ. Res, vol.113, pp.7-17, 2016.

M. Wang, J. J. Carver, L. M. Phelan, L. M. Sanchez, N. Garg et al., Sharing and community curation of mass spectrometry data with global natural products social molecular networking, Nat. Biotechnol, vol.34, pp.828-837, 2016.
URL : https://hal.archives-ouvertes.fr/hal-01371824

Y. Wang, S. Liu, Y. Hu, P. Li, and J. B. Wan, Current state-of-theart of mass spectrometry-based metabolomics studies -a review focusing on wide coverage, high throughput and easy identification, R. Soc. Chem, vol.5, pp.78728-78737, 2015.

J. L. Wilkinson, P. S. Hooda, J. Swinden, J. Barker, and S. Barton, Spatial (bio) accumulation of pharmaceuticals, illicit drugs, plasticisers, perfluorinated compounds and metabolites in river sediment, aquatic plants and benthic organisms, Environ. Pollut, vol.234, pp.864-875, 2018.

N. Withers and J. Nevenzel, Phytyl esters in a marine dinoflagellate, Lipids, vol.12, pp.989-993, 1977.

R. S. Wotton, The ubiquity and many roles of exopolymers (EPS) in aquatic systems, Sci. Mar, vol.68, pp.13-21, 2004.