Synthesis of 11-aza-artemisinin derivatives using the Ugi reaction and an evaluation of their antimalarial activity

Thanh Nguyen Le , Wim de Borggraeve (1) , Philippe Grellier (2) , van Cuong Pham (2) , Wim Dehaen (3) , van Hung Nguyen (4)

1 Katholieke Univ Leuven, Dept Chem, Celestijnenlaan 200F, B-3001 Heverlee, Belgium
2 MCAM - Molécules de Communication et Adaptation des Micro-organismes
3 Chemistry Department
4 ICSN - Institut de Chimie des Substances Naturelles

Domains: Chemical Sciences; Life Sciences [q-bio]; Microbiology and Parasitology

Thanh Nguyen Le, Wim de Borggraeve, Philippe Grellier, van Cuong Pham, Wim Dehaen, et al.. Synthesis of 11-aza-artemisinin derivatives using the Ugi reaction and an evaluation of their antimalarial activity. Tetrahedron Letters, 2014, 55 (35), pp.4892-4894. ⟨10.1016/j.tetlet.2014.07.027⟩. ⟨mnhn-02867426⟩