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Journal articles
Design, synthesis and antimalarial activity of novel, quinoline-Based, zinc metallo-aminopeptidase inhibitors
Abstract : PfA-M1, a neutral zinc aminopeptidase of Plasmodium falciparum, is a new potential target for the discovery of anti-malarials. The design and synthesis of a library of 45 quinoline-based inhibitors of PfA-M1 is reported. The best inhibitor displays an IC 50 of 854 nM. The antimalarial activity on a CQ-resistant strain and the specificity towards mammalian aminopeptidase N are also discussed. #
Cited literature [29 references]
https://hal-mnhn.archives-ouvertes.fr/mnhn-02867485
Contributor : Philippe Grellier <>
Submitted on : Tuesday, July 21, 2020 - 10:25:27 PM
Last modification on : Thursday, December 3, 2020 - 4:02:04 PM
Long-term archiving on: : Tuesday, December 1, 2020 - 4:02:55 AM
Contributor : Philippe Grellier <>
Submitted on : Tuesday, July 21, 2020 - 10:25:27 PM
Last modification on : Thursday, December 3, 2020 - 4:02:04 PM
Long-term archiving on: : Tuesday, December 1, 2020 - 4:02:55 AM
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2003_Flipo_BioorgMedChemLett.p...
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