Origin of an ancient hormone/receptor couple revealed by resurrection of an ancestral estrogen

Gabriel Markov (1, 2) , Juliana Gutierrez-Mazariegos (1) , Delphine Pitrat (3) , Isabelle Billas , François Bonneton (4) , Dino Moras (5) , Jens Hasserodt (3) , Guillaume Lecointre (6) , Vincent Laudet (1)

1 IGFL - Institut de Génomique Fonctionnelle de Lyon
2 MNHN - Muséum national d'Histoire naturelle
3 LC - Laboratoire de Chimie - UMR5182
4 CNRS - Centre National de la Recherche Scientifique
5 Inserm U964 - CNRS UMR7104 - IGBMC - Centre for Integrative Biology - CBI
6 ISYEB - Institut de Systématique, Evolution, Biodiversité

Cladistic analysis allows inference of the structure of an ancestral steroid that acts as a ligand for the ancestral receptor.

Domains: Life Sciences [q-bio]

Gabriel Markov, Juliana Gutierrez-Mazariegos, Delphine Pitrat, Isabelle Billas, François Bonneton, et al.. Origin of an ancient hormone/receptor couple revealed by resurrection of an ancestral estrogen. Science Advances , 2017, 3 (3), ⟨10.1126/sciadv.1601778⟩. ⟨mnhn-03935285⟩