Evolutionary demographic models reveal the strength of purifying selection on susceptibility alleles to late-onset diseases. - Archive ouverte HAL Access content directly
Conference Papers Year :

Evolutionary demographic models reveal the strength of purifying selection on susceptibility alleles to late-onset diseases.

(1)
1
S. Pavard

Abstract

Geneticists have long considered alleles involved in post-menopause mortality to be neutral as no reproduction occurs anymore. Population genetics models have predicted that genetic drift rather than purifying selection was shaping the allelic spectrum of late-onset diseases, leading to a few common variants explaining most of the diseases’ prevalences. However, recent association studies show that most susceptibility alleles to late onset diseases have low frequencies: a characteristic of alleles under negative selection. We show that susceptibility alleles to late onset diseases are under purifying selection for most known age-at-onset distributions of late-onset genetic diseases. We conclude that neutrality is probably the exception among alleles that have a deleterious effect in old age and that accounting for sociocultural factors is required to understand the full extent of the force of selection shaping senescence in humans.
Not file

Dates and versions

mnhn-03949111 , version 1 (20-01-2023)

Identifiers

  • HAL Id : mnhn-03949111 , version 1

Cite

S. Pavard. Evolutionary demographic models reveal the strength of purifying selection on susceptibility alleles to late-onset diseases.. Club EvMed — Virtual Evolutionary Medicine Conversations, Oct 2021, Virtual conference, France. ⟨mnhn-03949111⟩

Collections

MNHN CNRS ANR
0 View
0 Download

Share

Gmail Facebook Twitter LinkedIn More