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The Exostosin Immunohistochemical Status Differentiates Lupus Membranous Nephropathy Subsets With Different Outcomes

Michèle Saïdi 1, 2 Isabelle Brochériou 2, 1 Emmanuel Estève 3, 1 Sophie Tuffet 4 Zahir Amoura 5 Makoto Miyara 5 Xavier Belenfant 6 Tim Ulinski 7 Philippe Rouvier 2 Hanna Debiec 1 Pierre Ronco 1 David Buob 1, 2
1 Des Maladies Rénales Rares aux Maladies Fréquentes, Remodelage et Réparation
2 ACP - Service d'Anatomie et cytologie pathologiques = Service de Pathologie [CHU Pitié-Salpêtrière]
3 Service de Néphrologie et Dialyses [CHU Tenon]
4 URC-EST - Unité de Recherche Clinique de l’Est Parisien [CHU Saint-Antoine]
5 DMIIC - Service de Département de médecine interne et immunologie clinique [CHU Pitié-Salpêtrière]
6 CHI André Gregoire - Centre Hospitalier Intercommunal André Grégoire [Montreuil]
7 Service de néphrologie et pédiatrie générale [CHU Trousseau]
Abstract : Exostosin (EXT) 1 and EXT2 proteins are recently discovered major components of the subepithelial deposits in a subset of patients with membranous nephropathy (MN).1,2 Although the detection of EXT1/2 seems to be a distinctive feature of MN related to systemic lupus erythematosus (SLE),1 the exact frequency of EXT-positive, SLE-associated MN (SLE-MN) and its potential clinical significance are not well determined. Here, we retrospectively evaluated 86 consecutive patients with biopsy-proven pure class 5 SLE-MN diagnosed between January 2010 and December 2018 in 2 nephropathology centers (La Pitié Salpêtrière and Tenon hospitals) in Paris, France; mixed classes (3 + 5 and 4 + 5 of the 2003 ISN/Renal Pathology Society classification)3 were excluded.
Keywords : exostosin immunohistochemistry membranous nephropathy renal biopsy systemic lupus erythematosus
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Journal articles
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Submitted on : Monday, September 6, 2021 - 1:11:53 PM
Last modification on : Friday, May 20, 2022 - 11:06:42 AM
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U1155 | INSERM | SORBONNE-UNIVERSITE | SU-MEDECINE | SU-TI

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Michèle Saïdi, Isabelle Brochériou, Emmanuel Estève, Sophie Tuffet, Zahir Amoura, et al.. The Exostosin Immunohistochemical Status Differentiates Lupus Membranous Nephropathy Subsets With Different Outcomes. Kidney International Reports, Elsevier, 2021, 6 (7), pp.1977 - 1980. ⟨10.1016/j.ekir.2021.04.025⟩. ⟨hal-03335588⟩

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